Ngwaahịa

Nkọwa:glucoridin bụ isoflavane sitere na glycorrhiza glabra, nke nwere ike jikọta ma rụọ ọrụ PPAR γ, uru EC50 bụ 6115 nm.Glabridin nwere antioxidant, antibacterial, anti glomerulonephritis, mgbochi ọrịa shuga, mgbochi tumor, mgbochi mkpali, mgbochi osteoporosis, na-echebe obi obi, na-echebe irighiri akwara, scavenge free radicals na ndị ọzọ ọrụ.

Ụdị emetụtara:ubi nyocha > > kansa
Ụzọ mgbaàmà > > okirikiri cell / DNA mebiri >> PPAR
Ogige nyocha > > mbufụt / mgbochi

N'ime Vitro Ọmụmụ:glabridin na-ejikọta ma rụọ ọrụ PPAR γ, EC50 bụ 6115 nm [1].Glabridin (40,80 μ M) Mmụba nke ahịrị sel SCC-9 na SAS ka amachibidoro n'ụdị dose na oge dabere na awa 24 na 48 nke ọgwụgwọ [2].Glabridin (0-80 μM) Ọ na-ebute apoptosis, na-eduga na njide okirikiri sel G1 na SCC-9 na ahịrị sel SAS [2].Glabridin (0,20,40 na 80 μM) dose na-arụ ọrụ na-adabere na Caspase-3, - 8 na - 9 na mmụba PARP, nke ukwuu phosphorylating ERK1 / 2, JNK1 / 2 na P-38 MAPK na SCC-9.Sel [2].

Na Ọmụmụ Vivo:glabridin (50 mg / kg, Po otu ugboro kwa ụbọchị) gosipụtara ọrụ mgbochi mkpali siri ike ma kwalite mgbanwe mkpali nke dextran sodium sulfate (DSS) kpatara [3]

Ntụaka:[1] Rebhun JF, et al.Nchọpụta nke glabridin dị ka ihe na-eme bioactive na licorice (Glycyrrhiza glabra L.) wepụ nke na-eme ka mmadụ peroxisome proliferator-activated receptor gamma (PPAR γ).Fitoterapia.2015 Ọkt;106:55-61.
[2].Chen CT, et al.Glabridin na-ebute apoptosis na njide okirikiri cell na mkpụrụ ndụ kansa ọnụ site na ụzọ akara JNK1/2.Environ Toxicol.2018 Jun;33 (6): 679-685 .
[3].El-Ashmawy NE, et al.Mbelata nke iNOS na mbuli elu nke cAMP na-ebute mmetụta mgbochi mkpali nke glabridin na oke nwere ulcerative colitis.Inflammopharmacology.2018 Eprel;26 (2): 551-559 .