Hyperoside;Hypercin Cas No. 482-36-0
Ozi ọgwụ
(aha ngwaahịa) hypericin
[Aha bekee] Hyperoside
hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside.
[usoro ihe omimi] c21h20o12
[molecular arọ] 464.3763
[C dị ka Nọmba.] 482-36-0
[chemical classification] flavonoids
[isi iyi] Hypericum perforatum L
[Nkọwa]> 98%
[Nkọwa okwu nchekwa] 1. Ekula uzuzu.2.N'ihe mberede ma ọ bụ ahụ erughị ala, chọọ nlekọta ahụike ozugbo (gosi akara ya ma ọ bụrụ na ọ ga-ekwe omume).
A na-ekesa hypericin n'ọtụtụ ebe.Ọ bụ ngwaahịa dị mkpa sitere n'okike nwere ọtụtụ ihe omume physiological, dị ka mgbochi mkpali, antispasmodic, diuretic, ibelata ụkwara, mbelata ọbara mgbali, mbelata cholesterol, protein assimilation, mpaghara na Central analgesia, na-echebe mmetụta na obi na ụbụrụ arịa.
[Anụ ahụ na kemịkalụ] kristal acicular na-acha odo odo.Ebe mgbaze bụ 227 ~ 229 ℃, na ntụgharị anya bụ - 83 Celsius (C = 0.2, pyridine).Ọ na-agbaze ngwa ngwa na ethanol, methanol, acetone na pyridine ma kwụsie ike n'okpuru ọnọdụ nkịtị.Ọ na-emeghachi omume na hydrochloric acid magnesium ntụ ntụ iji mepụta cherry red, na ferric chloride na-emeghachi akwụkwọ ndụ akwụkwọ ndụ, α-Naphthol mmeghachi omume dị mma.
[Nkọwa okwu ihe egwu] na-emerụ ahụ ma iloro ya.
Ihe omume ọgwụ
1. Hypericin nwere mmetụta analgesic mpaghara dị ịrịba ama, nke adịghị ike karịa morphine, siri ike karịa aspirin, na enweghị ndabere.Hypericin bụ ụdị analgesic ọhụrụ nke mpaghara n'otu oge.
2. Hypericin nwere mmetụta nchebe dị mma na myocardial ischemia-reperfusion, cerebral ischemia-reperfusion na cerebral infarction.
3. Hypericin nwere mmetụta mgbochi mkpali doro anya: mgbe etinyere bọọlụ ajị anụ, a na-agbanye oke intraperitoneally na 20mg / kg kwa ụbọchị maka ụbọchị 7, nke na-egbochi usoro mkpali ahụ nke ukwuu.
4. Ọ nwere mmetụta antitussive siri ike.
5. Assimilation.
6. Mgbochi siri ike nke aldose reductase nwere ike ịba uru iji gbochie cataract ọrịa shuga.
Mmetụta nchebe na myocardial ischemia
Hypericin nwere ike belata ọnụ ọgụgụ apoptosis nke cardiomyocytes nke hypoxia reoxygenation kpatara, na-egbochi mwepụta nke lactate dehydrogenase, melite ọrụ myocardial superoxide dismutase (SOD) na oke nwere myocardial ischemia-reperfusion mmerụ, belata mmepụta nke malondialdehyde (MDA), gbochie mmụba nke myocardial phosphokinase (CPK) na serum, ma belata nguzobe oxygen free radical na nitric oxide free radical, Ya mere, iji chebe myocardium ma belata mmerụ ahụ cardiomyocyte na cardiomyocyte apoptosis kpatara ischemia-reperfusion.
Mmetụta nchebe na cerebral ischemia
Hypericin nwere ike igbochi mbelata nke formazan ọdịnaya na cerebral mpekere mgbe hypoxia glucose deprivation reperfusion mmerụ, na-amụba ọnụ ọgụgụ nke na-adị ndụ neurons na cortex na striatum nke cerebral Mpekere na ischemic mpaghara, na-eme ka morphology nke neurons zuru ezu na nke ọma ekesa.Na-egbochi mbelata ọrụ akwara ozi nke hypoxia glukos na-akpata mmerụ ahụ.Na-egbochi mbelata nke ọrụ SOD, LDH na glutathione peroxidase (GSHPx).Usoro ya nwere ike jikọta ya na mkpochapụ radical free, mgbochi nke ntinye Ca2 na nguzobe peroxide na-egbochi lipid.
Mmetụta nchebe na imeju na mucosa gastric
Hypericin nwere mmetụta nchebe doro anya na anụ ahụ imeju na mucosa gastric.Usoro ya metụtara mmetụta antioxidant, na-akwalite nlọghachi nke ọkwa N0 na nkịtị na ịba ụba ọrụ SOD.
Mmetụta antispasmodic analgesic
Nnyocha ahụ chọpụtara na mmetụta analgesic nke hypericin na-emepụta site na ibelata Ca 2 na njedebe akwara na-egbu mgbu.N'otu oge ahụ, hypericin nwere ike igbochi ntinye Ca 2 nke potassium dị elu na-ebute, na-egosi na hypericin na-egbochikwa ọwa Ca na anụ ahụ akwara.A na-atụ aro na hypericin nwere ike ịbụ ihe mgbochi nke ọwa Ca 2.Nleba anya n'ụlọ ọgwụ na-egosi na ịgba ọgwụ hypericin yiri atropine na ọgwụgwọ nke isi mmalite dysmenorrhea.Ewezuga mmetụta ole na ole na-ehi ụra, ọ nweghị mmeghachi omume ọjọọ dị ka tachycardia, mydriasis na mmetụta ọkụ.Ọ bụ ezigbo antispasmodic na analgesic.
Mmetụta hypopolipidemic
Hypericin nwere ike ibelata ọbara TC nke ọma ma mụbaa HDL / TC oke na oke oke abụba, na-egosi na hypericin nwere ike belata cholesterol, mezie lipid ọbara, ma melite ọrụ HDL na serum SOD na ụmụ oke.Mmetụta a nwere ike belata nke ukwuu mmebi nke superoxide free radical na vaskụla endothelium na hyperlipidemia, ma na-akwado ire ere na metabolism nke lipid peroxide iji chebe endothelium vaskụla.
Kwalite ọrụ mgbochi
Hypericin na doses nke 300 mg / kg na 150 mg / kg na vivo nwere ike igbochi index thymus, mmụba nke splin T na B lymphocytes na phagocytosis nke peritoneal macrophages;Na 59 mg / kg, ọ na-eme ka mmụba nke splin T na B lymphocytes na phagocytosis nke peritoneal macrophages.Hypericin na dose nke 50 ~ 6.25 ml in vitro nwere ike ịkwalite mmụba nke splin T na B lymphocytes ma kwalite ikike nke T lymphocytes iji mepụta IL-2;Hypericin na 6.25 g / ml na-abawanye ike nke peritoneal macrophages òké na phagocytize neutrophils, sitere na 12.5 ruo 3.12 μG / ml na-abawanye ike nke peritoneal macrophages nke òké iji hapụ No.
Mmetụta antidepressant
Hypothalamic pituitary adrenal (HPA) ịgbalite bụ mgbanwe ndụ na-ahụkarị na ndị ọrịa nwere oke ịda mbà n'obi, nke ejiri oke nzuzo nke adrenocorticotropic hormone (ACTH) na cortisol mara.Hypericin nwere ike ịhazi ọrụ nke axis HPA ma belata ọkwa ACTH na corticosterone, ka ọ rụọ ọrụ antidepressant.
Ọgwụgwụ Emechara
Ciwujia capsule
Acanthopanax senticosus capsule bụ nkwadebe nwere Acanthopanax senticosus stem na mpempe akwụkwọ dị ka akụrụngwa.Ihe mejupụtara ya bụ flavonoids, nke hypericin bụ isi ihe na-arụ ọrụ nke akwụkwọ Acanthopanax senticosus.
Isi ihe na-egosi: ịkwalite mgbasa ọbara na iwepu stasis ọbara.A na-eji ya maka arthralgia obi na ọrịa obi nke ọbara na-akpata.Mgbaàmà gụnyere mgbu obi, njigide obi, obi mgbawa, ọbara mgbali elu, wdg. ọ bụ nke erughi splin na akụrụ na ọbara stasis na Yin.
Capsule nke Xinan
Ọ bụ nkwadebe sitere na mpempe akwụkwọ hawthorn, nke bara ụba na flavonoids, nke hypericin bụ otu n'ime ihe ndị bụ isi.
Isi ihe na-egosi: gbasaa sistemu akwara obi, melite ọkọnọ ọbara myocardial ma belata lipid ọbara.A na-eji ya agwọ ọrịa obi obi, angina pectoris, nkụchi obi, obi mgbawa, ọbara mgbali elu, wdg.
Mbadamba ụrọ Qiyue Jiangzhi
Mbadamba ụrọ Qiyue Jiangzhi bụ ọgwụ ọdịnala China dị ọcha na-eweda egbugbere ọnụ nke a kwadebere site na iwepụta akụkụ dị mma nke ọgwụ ọdịnala ndị China dị ka hawthorn (enucleated) na Astragalus membranaceus.Otu n'ime ihe ndị bụ isi dị irè nke hawthorn bụ flavonoids, nke ọdịnaya hypericin dị elu.
Isi ihe na-egosi: belata lipid ọbara ma mee ka arịa ọbara dị nro.A na-eji ya kwalite mgbasa ọbara ọbara yana ịlụso arrhythmia na hyperlipidemia ọgụ.
Mbadamba ụrọ nke Xinxuening
Mbadamba ụrọ Xinxuening bụ nkwadebe ngwakọta emere nke ọgwụ ọdịnala ndị China dị ka hawthorn na pueraria.Hawthorn bụ ọgwụ gọọmentị nke otu anyị.O nwere ursolic acid, Vitexin rhamnoside, hypericin, citric acid, wdg, nke hypericin bụ isi ihe mejupụtara ya.
Isi ihe na-egosi: ịkwalite mgbasa ọbara na iwepu stasis ọbara, ịdọrọ ihe nkwekọrịta na ibelata mgbu.A na-eji ya maka arthralgia obi na vertigo kpatara site na ọbara stasis na ụbụrụ ụbụrụ, yana ọrịa obi obi, ọbara mgbali elu, angina pectoris na hyperlipidemia.
Yukexin capsule
Yukexin Capsule bụ nkwadebe ọgwụ ọdịnala ndị China ewepụtara site na ndenye ọgwụ oge ochie, nke mejupụtara Hypericum perforatum, kernel ọhịa jujube, ogbugbo Albizzia, Gladiolus na ọgwụ ndị China ọdịnala ndị ọzọ.Ọ kachasị nwere hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, yimaning, hypericin na ihe ndị ọzọ.
Isi ihe na-egosi: ịda mbà n'obi nke uche kpatara nhụsianya nke imeju qi na ọnọdụ adịghị mma.
