Jujuboside A CAS Nọmba 55466-04-1
Ozi dị mkpa
Utu aha Chinese:jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (ọkọlọtọ)
Aha Bekee:Jujuboside A
Isi mmalite ihe ọkụkụ:ọ na-abịa site na mkpụrụ osisi jujube ọhịa, nke a makwaara dị ka jujube kernel na ọhịa jujube core
Usoro ihe omimi:C58H94O26
Arọ molikula:1207.35
CAS Mba.55466-04-1
Bioactivity nke Jujuboside A
Ebumnuche:GABA nnata, mTOR, PI3K, Akt [1] [2]
Ọmụmụ in vitro:obere dose 41 μ Jujuboside A nke M (ihe dị ka 0.05 g / L) kpalitere GABA (a) ndị na-anabata ya n'oge 24 na 72 h ọgwụgwọ α 1, α 5, β 2 subunit mRNA mụbara nke ukwuu.Nnukwu dose 82 μM (ihe dị ka 0.1 g / L) Jujuboside A na-abawanye GABA (a) ndị na-anabata ya na ọkwa 24 h α 1, α 5 subunit mRNA ma belata β 2 subunit mRNA larịị ma belata GABA (a) subunit α 1 A na-emeso okwu β2 mRNA na 72 h [1].Jujuboside Ngwọta mbụ nwere ike weghachi mbelata nke ịdị ndụ cell ma mee ka mmerụ ahụ H9c2 kpatara ISO nke ọma.Jujuboside A nwere ike mee ngwangwa phosphorylation nke PI3K, Akt na mTOR.Jujuboside A nwere ike ibelata nke ukwuu nke microtubule protein metụtara LC3-II / I na sel H9c2 [2]
Ọmụmụ ihe na vivo:n'ehihie (9:00-15:00), jujubosides na-abawanye ụbara ụra zuru oke na mmegharị anya ngwa ngwa (REM), mana enweghị mmetụta dị ukwuu na ụra na-abụghị REM (NREM).N'abalị (21: 00-3: 00), jujubosides na-abawanye ụbara ụra zuru oke na ụra NREM, karịsịa ụra dị nro, mana enweghị mmetụta dị ukwuu na ụra REM na ụra ụra na-adịghị nwayọọ (SWS) [3].A na-ebelata ọgwụgwọ intraventricular na jjuboside a nke ọma site na a site na Y-maze, izere arụ ọrụ na nha maze mmiri Morris β 1-42 butere mmụta na nsogbu ebe nchekwa na ụmụ oke.Intracerebroventricular injection nke Jujuboside A mbelata hippocampal a β 1-42 ọkwa gbochiri nke ukwuu ọrụ nke acetylcholinesterase (AChE) na mba, na ibelata ụba ọdịnaya nke malondialdehyde (MDA) na hippocampus na cerebral cortex nke ụmụ oke igbaba n'ime mpụta ventricle β 1-42 β . [4].
Nnwale cell:mgbe ụbọchị 7 nke omenala in vitro gasịrị, a na-ekpughere mkpụrụ ndụ ahụ ruo awa 24 ma ọ bụ awa 72, ma ekpuchighị ya na usoro nwere Jujuboside A ma ọ bụ diazepam ma ọ bụ ha abụọ.Agbakwunyere vector na otu njikwa;Otu Diazepam gbakwunyere 10 μ M diazepam;Jujuboside A82 μM (ihe dị ka 0.1g / L) na 41 μM (ihe dị ka 0.05 g / L) ka agbakwunyere na jua-h (oke dose Jujuboside A) na jua-l (Jujuboside A) dị ala, n'otu n'otu.Mkpokọta RNA dịpụrụ adịpụ na sel maka nyocha ọzọ [1].
Nnwale anụmanụ:ụmụ oke: agbanyere a site na ICV β 1-42 butere nkwarụ n'ime ụmụ oke.Mgbe ahụ, a gbara ụmụ oke na Jujuboside A (0.02 na 0.2 mg / kg) intraventricular (ICV) maka ụbọchị ise.Y maze, mgbanarị na-arụsi ọrụ ike na nyocha mmiri Morris ka emere na ụmụ oke [1].
Utu aha Bekee nke Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R) -16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- > 2)-O-[O-β-D-glucopyranosyl- (1-> 6) -O- )]-
(3β,16β,23R) -20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl- (1-> 6)-[β-D-xylopyranosyl- (1-> 2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside.
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R) -16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- > 2) -O-[O-β-D-glucopyranosyl- (1-> 6) - O- )]-
JujubosideA
(3β,16β,23R) -20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl- (1-> 6)-[β-D-xylopyranosyl- (1-> 2)]-β-D-glucopyranosyl- (1-> 3)] -α-L-arabinopyranoside.
