Naringenin-7-O-neohesperidoside;Naringin;Isonaringenin CAS Nke 10236-47-2
Okwu mmalite
Aha Bekee:narin
Ojiji:enwere ike iji ya dị ka ihe mgbakwunye nri, tumadi maka shuga chịngọm, ihe ọṅụṅụ dị jụụ, wdg.
Njirimara physicochemical:naringin bụ mgbagwoju nke glucose, rhamnose na naringin.Ọ bụ ntụ ntụ kristal na-acha ọcha na-acha odo odo.Na mkpokọta, ọ nwere mmiri kristal 6 ~ 8 nwere ebe agbaze nke 83 ℃.Ihicha na ịdị arọ mgbe niile na 110 ℃ iji nweta kristal nwere mmiri kristal 2, yana ebe agbaze nke 171 ℃.Naringin nwere uto ilu nke ukwuu, na ngwọta mmiri nke nwere mkpokọta 20mg / kg ka nwere uto ilu.Na-agbaze ntakịrị na mmiri, na-agbaze ngwa ngwa na mmiri ọkụ, ethanol, acetone na glacial acetic acid na-ekpo ọkụ.Enwere otu phenolic hydroxyl n'ime ihe owuwu ahụ, ihe ngwọta ya nke mmiri na-esighi ike.Ngwaahịa "citrus glucoside dihydrochalcone" mgbe hydrolysis na hydrogenation bụ ihe na-atọ ụtọ, na ụtọ bụ ihe karịrị ugboro 150 nke sucrose.
Sistemụ ọnụọgụgụ
Nọmba CAS: 10236-47-2
Nọmba MDL: mfcd00149445
EINECS Nọmba: 233-566-4
Nọmba RTECS: qn6340000
Nọmba BRN: 102012
Data Akụrụngwa
1. Ihe odide: naringin bụ mgbagwoju anya nke glucose, rhamnose na grepfruit gametophyte.Ọ bụ ntụ ntụ kristal na-acha ọcha na-acha odo odo.
2. Ebe mgbaze (º C): 171
3. Ntụgharị uche: - 84
4. Ntụgharị pụrụ iche (º): - 91
5. Solubility: ubé soluble na mmiri, mfe soluble na mmiri ọkụ, ethanol, acetone na ọkụ glacial acetic acid.
Data Toxicology
1. Usoro ule: oghere afọ
Nri oriri: 2 mg / kg
Ihe nnwale: òké òké
Ụdị nsi: nnukwu
Mmetụta na-egbu egbu: a kọwapụtaghị ihe nsi na mmetụta dị n'ụzọ zuru ezu ma e wezụga ụkpụrụ dose ndị ọzọ na-egbu egbu
2. Usoro ule: oghere afọ
Nri oriri: 2 mg / kg
Nnwale ihe: rodent Guinea pig
Ụdị nsi: nnukwu
Mmetụta na-egbu egbu: a kọwapụtaghị ihe nsi na mmetụta dị n'ụzọ zuru ezu ma e wezụga ụkpụrụ dose ndị ọzọ na-egbu egbu
Data gburugburu ebe obibi
Ihe a nwere ike imebi gburugburu ebe obibi, n'ihi ya, ekwesịrị itinye nlebara anya pụrụ iche na mmiri.
Data Ọdịdị Molecular
1. Ntụgharị ntugharị molar: 135.63
2. Mgbidi olu (cm3 / mol): 347.8
3. Isotonic kpọmkwem olu (90.2k): 1103.4
4. Esemokwu dị n'elu (dyne / cm): 101.2
5.Polarizability (10-24cm3): 53.76 [2]
Gbakọọ data kemịkalụ
1. Ntụaka uru maka hydrophobic parameter ngụkọta oge (xlopp): - 0,5
2. Ọnụọgụ nke ndị na-enye njikọ hydrogen: 8
3. Ọnụọgụ nke ndị nnabata hydrogen: 14
4. Ọnụọgụ nke njikọ kemịkalụ rotatable: 6
5. Topological molecular polar surface area (TPSA): 225
6. Ọnụọgụ atọm dị arọ: 41
7. Ụgwọ elu: 0
8. Mgbagwoju anya: 884
9. Ọnụọgụ nke atọm isotopic: 0
10. Kpebie ọnụ ọgụgụ nke atọm stereocenters: 11
11. Ọnụọgụ nke stereocenter atomic na-ejighị n'aka: 0
12. Kpebie ọnụọgụ kemịkalụ stereocenters: 0
13. Ọnụọgụ nke stereocenter kemịkalụ na-enweghị njedebe: 0
14. Ọnụọgụ nke covalent bond units: 1
Ngwongwo na kwụsie ike
Ọ bụrụ na ejiri ya ma chekwaa ya dịka nkọwapụta, ọ gaghị erere.
Usoro nchekwa
A na-eji akpa akwụkwọ kraft kpuchie akpa rọba nri nri maka nkwakọ ngwaahịa ejiri akara.Chekwaa na ebe dị jụụ na nkụ.
Ebumnuche
Mkpụrụ osisi grepu bara ụba na naringin, nke dị ihe dịka 1%.Ọ kachasị dị na peel, capsule na mkpụrụ.Ọ bụ isi ihe na-elu ilu dị na mkpụrụ grepu.Naringin nwere uru akụ na ụba dị elu ma nwee ike iji mee ihe ụtọ dihydrochalcone ọhụrụ, yana ọgwụ maka mgbochi na ọgwụgwọ ọrịa obi, allergies na mbufụt.
1. Enwere ike iji ya dị ka ihe mgbakwunye oriri, tumadi maka shuga chịngọm, ihe ọṅụṅụ dị jụụ, wdg.
2. Enwere ike iji ya mee ihe dị ka akụrụngwa maka njikọ nke ọhụrụ sweeteners dihydronaringin chalcone na neohesperidin dihydrochalcone na nnukwu ụtọ, na-abụghị toxicity na obere ume.
Usoro mmịpụta
Naringin na-agbaze ngwa ngwa na mmanya na-egbu egbu na ngwọta alkali, a pụkwara ịgbaze ya na mmiri ọkụ.Dị ka njirimara a si dị, a na-ewepụtakarị naringin site na usoro alkali na usoro mmiri ọkụ.Usoro mmepụta bụ dị ka ndị a: Pomelo Peel → ịkụpịa → leaching na mmiri lime ma ọ bụ mmiri ọkụ → filtration → jụrụ oyi na mmiri ozuzo → nkewa → ihicha na ikpochapụ → ngwaahịa emechara.
Ụzọ mmiri ọkụ
Usoro mmịpụta mmiri na-ekpo ọkụ bụ nke a: mgbe a gbajiri peel pomelo, tinye 3 ~ 4 ugboro mmiri, kpoo ọkụ na obụpde maka 30min, ma pịa iji nweta nzacha.Enwere ike ịmegharị usoro a ugboro 2 ~ 3.Mgbe filtrate na-lekwasị maka 3 ~ 5 ugboro, ọ ka (0 ~ 3 ℃) na-ebuli na crystallize, filter na kewapụrụ, na precipitate bụ crude ngwaahịa.Enwere ike nụchaa ya na mmanya ma ọ bụ mmiri ọkụ.Usoro a nwere obere mgbake na ogologo oge mmiri ozuzo.N'oge na-adịbeghị anya, Citrus Research Institute of Chinese Academy of Agricultural Sciences emeela ka usoro ahụ dịkwuo mma, ya bụ, a na-eji ihe yist ma ọ bụ pectinase na-eme ihe na-emepụta ihe, nke na-ebelata oge mmiri ozuzo ma na-eme ka mkpụrụ na ịdị ọcha dị ihe dị ka 20% ~ 30%.Enwere ike iji ihe fọdụrụ peel foduru wepụ pectin.
Usoro Alkali
Usoro alkali bụ ịkwanye ihe fọdụrụ akpụkpọ anụ na mmiri lime (pH12) maka 6 ~ 8h wee pịa ya iji nweta nzacha.Tinye nzacha n'ime ite Sanwichi, wepụ ya na 1: 1 hydrochloric acid na pH 4.1 ~ 4.4, kpoo ya na 60 ~ 70 ℃, ma mee ka ọ dị ọkụ maka 40 ~ 50min.Mgbe ahụ dị jụụ na obere okpomọkụ iji mee ka naringin, na-anakọta mmiri ozuzo, kpoo mmiri na centrifuge, tinye ya n'ime ụlọ ihicha, kpoo ya na 70 ~ 80 ℃, gwepịa ya na ntụ ntụ dị mma, nke bụ ngwaahịa crude.Tinyegharịa crystallization na mmanya na-ekpo ọkụ maka oge 2 ~ 3 iji nweta ngwaahịa dị ọcha.
Usoro emelitere
Site na usoro a dị n'elu, shuga, pectin, protein, pigmenti na ihe ndị ọzọ dị na peel pomelo na-abanye na ngwọta mmịpụta n'otu oge, na-eme ka ịdị ọcha dị ala nke ngwaahịa na ọtụtụ nzọụkwụ recrystallization maka ịdị ọcha.Ya mere, oge mmịpụta dị ogologo, usoro ahụ dị mgbagwoju anya, na ihe mgbaze, ike na ọnụ ahịa na-abawanye.Iji mee ka usoro ahụ dị mfe, melite ịdị ọcha nke ngwaahịa ma belata ọnụ ahịa, ọtụtụ nchọpụta e meela na usoro mgbake nke naringin.Li Yan et al.(1997) jiri ultrafiltration dokwuo anya naringin wepụ.Enwere ike ịbawanye ịdị ọcha nke ngwaahịa a nwetara site na crystallization site na 75% nke usoro alkali ọdịnala ruo 95%.Ọnọdụ ọrụ nke ultrafiltration dị ka ndị a: nrụgide 0.15 ~ 0.25MPa, na-ekesa flux 180L / h, pH 9 ~ 10 na okpomọkụ banyere 50 ℃.Japan Itoo (1988) jiri macroporous adsorption resin diion HP-20 sachaa naringin nke ọma.Wu houjiu et al.(1997) kọkwara na ọtụtụ resins adsorption macroporous ụlọ nwere ezigbo mgbasa ozi na ihe nyocha maka naringin, nke enwere ike iji maka nkewa na sachaa naringin.Na nchịkọta, onye odee na-ewepụta usoro emelitere nke a.The eruba chaatị bụ dị ka ndị a: Pomelo Peel → etipịa → mmiri ọkụ mmịpụta → filtration → ultrafiltration → ultrafiltration permeate → resin adsorption → nyocha ngwọta → ịta → jụrụ oyi → nkewa → puku ihicha → okokụre ngwaahịa.
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