Salvianolic acid C
Ebumnuche
Salvianolic acid C bụ onye na-adịghị asọmpi nke cytochrome p4502c8 (cyp2c8) na onye na-egbochi cytochrome P4502J2 (CYP2J2) nwere oke ike.Ụkpụrụ Ki ya maka cyp2c8 na CYP2J2 bụ 4.82 n'otu n'otu μ M na 5.75 μM
Aha bekee
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl) - 7-hydroxy-1-benzofuran-4-yl]-2- propanoyl oxy) propanoic acid
Utu aha Bekee
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-1-benzofuran-4-yl] prop-2 -enoyl}oxy) propanoic acid
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-1-benzofuran-4-yl]-2- propanoyl oxy) propanoic acid
Benzenepropanoic acid, α-[[(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl] oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Njirimara physicochemical nke Salvianolic Acid C
Njupụta: 1.6 ± 0.1 g / cm3
Ebe esi esi: 844.2 ± 65.0 ° C na 760 mmHg
Ụdị ihe omimi: C26H20O10
Arọ Molecular: 492.431
Ebe ọkụ: 464.4 ± 34.3 Celsius C
Ọnụ ọgụgụ ziri ezi: 492.105652
PSA: 177.89000
Ihe ndekọ: 3.12
Nrụgide Steam: 0.0 ± 3.3 mmHg na 25 Celsius
Ntụgharị ntụgharị: 1.752
Bioactivity nke Salvianolic acid C
Nkọwa:
Salvianolic acid C bụ onye na-adịghị asọmpi nke cytochrome p4502c8 (cyp2c8) na onye na-egbochi cytochrome P4502J2 (CYP2J2) nwere oke ike.Ụkpụrụ Ki ya maka cyp2c8 na CYP2J2 bụ 4.82 n'otu n'otu μ M na 5.75 μM.
Otu dị mkpa:
Ụzọ mgbaama > > metabolic enzyme / protease > > cytochrome P450
Ogige nyocha > > ọrịa kansa
Ngwaahịa eke > > ndị ọzọ
Ebumnuche:
CYP2C8: 4.82 μM (Ki)
CYP2J2: 5.75 μM (Ki)
N'ime Vitro Ọmụmụ:
Salvianolic acid C bụ ihe mgbochi agwakọta agafeghị oke nke cyp2c8 inhibitor na CYP2J2.KIS nke cyp2c8 na CYP2J2 bụ 4.82 na 5.75 n'otu n'otu μ M[1].Salvianolic acid C nke ukwuu belatara okwu nke iNOS.Salvianolic acid C na-egbochi LPS butere TNF-a, IL-1 β, IL-6 na IL-10 ka emepụtara.Salvianolic acid C na-egbochi ọrụ LPS NF-κ B.Salvianolic acid C mụbara okwu Nrf2 na HO-1 na BV2 microglia [2].
Na ọmụmụ Vivo:
Ọgwụgwọ Salvianolic acid C (20mg / n'arọ) belatara nke ukwuu nke mgbapụ.Na mgbakwunye, ọgwụgwọ SALC (10 na 20 mg / n'arọ) mụbara ọnụ ọgụgụ nke ngafe ikpo okwu nke ukwuu ma e jiri ya tụnyere otu ụdị LPS.E jiri ya tụnyere otu ụdị, nchịkwa usoro nke salvianolic acid C na-achịkwa ụbụrụ TNF-α, IL-1 β na ọkwa IL-6.Ọkwa nke iNOS na COX-2 na ụbụrụ ụbụrụ na hippocampus nke oke dị elu karịa ndị nọ na njikwa, ebe ọgwụgwọ salvianolic acid C na-achịkwa cortex na hippocampus.Salvianolic acid C (5, 10 na 20 mg / kg) ọgwụgwọ mụbara p-ampk, Nrf2, HO-1 na NQO1 ọkwa na oke cerebral cortex na hippocampus n'ụzọ dabere dose [2].
Ntụaka:
[1].Xu MJ, et al.Mmetụta mgbochi nke akụkụ Danshen na CYP2C8 na CYP2J2.Ozi gbasara ụlọ ọrụ Chem Biol Interact.2018 Jun 1;289:15-22 .
[2].Abụ J, et al.Nrụ ọrụ nke Nrf2 nrịbama site na salvianolic acid C na-eme ka NF κ B na-eme ka mmeghachi omume na-egbuke egbuke ma na vivo na in vitro.Int Immunopharmacol.2018 Ọkt;63:299-310.
