Isoliquiritin Apioside
Aplikasi saka Isoliquiritin Apioside
Isoliquiritin apioside, komponèn diisolasi saka glikorrhizae radio rhome, Ngartekno suda PMA induced Tambah ing aktivitas MMP9 lan nyandhet PMA induced MAPK lan NF-κ B aktivasi.Isoliquitin apioside nyegah invasi lan angiogenesis sel kanker lan sel endothelial.
Jeneng Isoliquiritin Apioside
Jeneng Cina:Isoliquiritin Apioside
Jeneng Inggris:(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioaktivitas Isoliquiritin Apioside
katrangan:isoliquitin apioside, komponèn diisolasi saka glikorrhizae radio rhome, Ngartekno suda PMA mlebokake Tambah ing kegiatan MMP9 lan nyandhet PMA mlebu MAPK lan NF-κ B aktivasi.Isoliquitin apioside nyegah invasi lan angiogenesis sel kanker lan sel endothelial.
GegandhenganCkategori:lapangan riset > > kanker
Jalur sinyal > > jalur sinyal MAPK / ERK > > p38 MAPK
Jalur sinyal > > enzim metabolik / protease > > MMP
Target:MMP9
NF-kB
p38 MAPK
Sinau in vitro:isorlicin bisa efektif nyandhet aktivitas gelation MMP-9 saka sel HT1080 sing diinduksi PMA.Isoglycyrrhizin apigenin nyuda paningkatan produksi MMP-9 ing sel HT1080 sing disebabake dening PMA, nduweni kemampuan anti metastasis lan anti angiogenesis ing sel tumor ganas lan sel endothelial, lan ora nduweni sitotoksisitas [1].
Referensi:[1].Kim A1, dkk.Isoliquiritin Apioside Nyandhet in vitro Invasiveness lan Angiogenesis saka Sel Kanker lan Sel Endothelial.Front Pharmacol.2018 Desember 10; 9:1455.
Sifat fisikokimia saka Isoliquiritin Apioside
Kapadhetan: 1,6 ± 0,1 g / cm3
Titik didih: 901,0 ± 65,0 ° C ing 760 mmHg
Rumus molekul: c26h30o13
Bobot molekul: 550.509
Titik nyala: 301,9 ± 27,8 ° C
Massa akurat: 550.168640
PSA: 215.83000
LogP: 1.96
Tekanan uap: 0,0 ± 0,3 mmHg ing 25 ° C
Indeks bias: 1.709
Jeneng Inggris Isoliquiritin Apioside
2-Propen-1-siji,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oksi]fenil]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]fenil 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
