Jujuboside A CAS No.. 55466-04-1
Informasi Penting
Alias Cina:jujube kernel saponin A, jujube kernel saponin A;Jujube kernel saponin A (standar)
Jeneng Inggris:Jujuboside A
Sumber tanduran:asalé saka wiji jujube alam bébas, uga dikenal minangka kernel jujube lan inti jujube alam bébas
Formula molekul:C58H94O26
Bobot molekul:1207.35
Nomer CAS55466-04-1
Bioaktivitas Jujuboside A
Target:Reseptor GABA, mTOR, PI3K, Akt [1] [2]
Sinau in vitro:dosis kurang 41 μ Jujuboside A saka M (kira-kira 0,05 g / L) induksi GABA (a) reseptor sak perawatan 24 lan 72 h α 1， α 5， β 2 subunit mRNA mundhak Ngartekno.Dosis dhuwur 82 μ M (kira-kira 0,1 g / L) Jujuboside A kanthi signifikan nambah reseptor GABA (a) ing 24 h α 1， α 5 tingkat mRNA subunit lan nyuda tingkat mRNA subunit β 2 lan nyuda GABA (a) subunit reseptor α 1， Ekspresi mRNA β2 diobati ing 72 jam [1].Jujuboside A pretreatment bisa mbalikke nyuda saka panguripan sel lan luwih ngindhuksi ISO induced sel H9c2 bundhas.Jujuboside A bisa nyepetake fosforilasi PI3K, Akt lan mTOR.Jujuboside A bisa nyuda proporsi microtubule related protein LC3-II / I ing sel H9c2 [2]
Sinau ing vivo:sak dina (9:00-15:00), jujubosides Ngartekno tambah total turu lan gerakan mripat cepet (REM) turu, nanging ora duwe pengaruh pinunjul ing non REM (NREM) turu.Ing wayah wengi (21:00-3:00), jujubosides nambah total turu lan turu NREM, utamane turu entheng, nanging ora ana pengaruh sing signifikan marang turu REM lan turu gelombang alon (SWS) [3].Pangobatan intraventricular karo jjuboside a dikurangi kanthi signifikan dening Y-maze, panyegahan aktif lan pangukuran mbingungake banyu Morris β 1-42 sing nyebabake pembelajaran lan gangguan memori ing tikus.Injeksi intracerebroventricular saka Jujuboside A nyuda tingkat hippocampal a β 1-42 sacara signifikan nyegah aktivitas acetylcholinesterase (AChE) lan ora, lan nyuda isi tambah malondialdehida (MDA) ing hippocampus lan korteks serebral tikus sing disuntikake menyang ventrikel lateral β 1-42. [4].
Eksperimen sel:sawise 7 dina kultur in vitro, sel kasebut terus-terusan nganti 24 jam utawa 72 jam, lan ora kena ing medium sing ngemot Jujuboside A utawa diazepam utawa loro-lorone.Vektor ditambahake menyang grup kontrol;Klompok diazepam ditambahake 10 μ M diazepam;Jujuboside A82 μ M (kira-kira 0,1 g / L) lan 41 μ M (kira-kira 0,05 g / L) ditambahake menyang jua-h (dosis dhuwur Jujuboside A) lan jua-l (dosis rendah Jujuboside A).Total RNA diisolasi saka sel kanggo analisis luwih lanjut [1].
Eksperimen kewan:tikus: a disuntikake liwat ICV β 1-42 nyebabake gangguan kognitif ing tikus.Banjur, tikus disuntikake Jujuboside A (0,02 lan 0,2 mg / kg) intraventricular (ICV) suwene 5 dina.Y labirin, panyegahan aktif lan tes labirin banyu Morris ditindakake ing tikus [1].
Alias Inggris saka Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
