Orientin
Aplikasi saka Orientin
Orientin minangka flavonoid bioaktif alami kanthi macem-macem ciri biologis, kalebu anti-inflamasi, antioksidan, anti-tumor, perlindungan jantung lan liya-liyane.Orientin minangka agen neuroprotective sing janjeni, sing cocog kanggo perawatan nyeri neuropatik.
Bioaktivitas Orientin
katrangan:orientin minangka flavonoid bioaktif alami kanthi macem-macem ciri biologis, kalebu anti-inflamasi, antioksidan, anti-tumor, perlindungan jantung lan liya-liyane.Orientin minangka agen neuroprotective sing janjeni, sing cocog kanggo perawatan nyeri neuropatik.
Kategori sing gegandhengan:lapangan riset > > kanker
Jalur sinyal > > liyane > > liyane
Bidang riset > > penyakit saraf
Referen:[1].Dhakal H, et al.Efek inhibisi orientin ing inflamasi alergi sing dimediasi sel mast.Pharmacol Rep. 2020 Jan 24.
[2].Guo D, et al.Orientin lan nyeri neuropatik ing tikus kanthi ligasi saraf spinal.61 Int Immunopharmacol.2018 Mei;58:72-79.
Sifat Fisikokimia Orientin
Kapadhetan: 1,8 ± 0,1 g / cm3
Titik didih: 816,1 ± 65,0 ° C ing 760 mmHg
Titik lebur: 260-285 º C
Formula Molekul: C21H20O11
Bobot molekul: 448,377
Titik nyala: 289,1 ± 27,8 ° C
Massa Akurat: 448.100555
PSA: 201.28000
LogP: 1.58
Penampilan: bubuk kuning
Tekanan Uap: 0,0 ± 3,1 mmHg ing 25 ° C
Indeks bias: 1.767
Kelarutan banyu: 1 M
NaOH: larut 1 mg/ml, bening, oranye kuning
Informasi safety digitalis
Pernyataan safety (Eropa): 24/25
Kode transportasi barang mbebayani: nonh kanggo kabeh mode transportasiRTECS号:DJ3009300
Tinjauan pustaka Orientin
Bedane pasangan isomer C-glycosylflavone orientin/isoorientin lan vitexin/isovitexin nggunakake pangukuran massa pas HPLC-MS lan CID sumber.
Phytochem.Dubur.16(5), 295-301, (2005)
HPLC-MS nggunakake collision induced disociation (CID) wis digunakake kanggo identifikasi pasangan isomer C-glycosylflavone orientin/isoorientin lan vitexin/isovitexin.Analisis produk HPLC-CID/MS..
Efek antihipertensi lan kardioprotektif saka woh Lagenaria siceraria ing tikus hipertensi sing disebabake NG-nitro-L-arginine metil ester (L-NAME).
Pharm.biol.50(11), 1428-35, (2012)
Lagenaria siceraria (Molina) Standl.(Cucurbitacae) (LS) wis kacarita nduweni aktivitas kardioprotektif, antihiperlipidemik, lan diuretik. Kanggo ngevaluasi efek antihipertensi lan kardioprotektif...
Pengembangan lan validasi metode HPTLC kanggo jumlah simultan isoorientin, isovitexin, orientin, lan vitexin ing flavonoid godhong bambu.
J. AOAC Int.93(5), 1376-83, (2010)
Cara HPTLC sing prasaja wis dikembangake kanggo nemtokake isoorientin, isovitexin, orientin, lan vitexin kanthi simultan, murni lan ing conto komersial flavonoid godhong bambu.Flavon kasebut ...
Alias Inggris saka Orientin
(1S)-1,5-Anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-D-glucitol
2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran- 2-yl]-4H-chromén-4-siji
Orientin 8-C-β-D-glucopyranoside
3',4',5,7-tetrahydroxyflavone-8-C-glucoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran- 2-yl]-4H-chromen-4-on
Luteolin-8-C-glukosida
3',4',5,7-tetrahydroxyflavone 8-glukosida
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-
D-Glucitol, 1,5-anhydro-1-C-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-8-yl]-, (1S) -
Orientin
lutexin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran- 2-yl]-4H-chromen-4-siji
2-(3,4-Dihydroxyphenyl)-8-bD-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
