Asam salvianolat C
tujuane
Asam Salvianolic C minangka inhibitor sitokrom p4502c8 (cyp2c8) sing ora kompetitif lan inhibitor campuran sitokrom P4502J2 (CYP2J2) kanthi intensitas medium.Nilai Ki kanggo cyp2c8 lan CYP2J2 masing-masing 4,82 μ M lan 5,75 μ M
Jeneng Inggris
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) asam propanoat
Alias Inggris
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) asam propanoat
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) asam propanoat
Asam Benzenepropanoic, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihidroksi-, (αR)-
Asam salvianolat C
Sifat Fisikokimia Asam Salvianolat C
Kapadhetan: 1,6 ± 0,1 g / cm3
Titik didih: 844,2 ± 65,0 ° C ing 760 mmHg
Formula Molekul: C26H20O10
Bobot molekul: 492,431
Titik nyala: 464,4 ± 34,3 ° C
Massa pas: 492.105652
PSA: 177.89000
LogP: 3.12
Tekanan Uap: 0,0 ± 3,3 mmHg ing 25 ° C
Indeks bias: 1.752
Bioaktivitas Asam Salvianolat C
katrangan:
Asam Salvianolic C minangka inhibitor sitokrom p4502c8 (cyp2c8) sing ora kompetitif lan inhibitor campuran sitokrom P4502J2 (CYP2J2) kanthi intensitas medium.Nilai Ki kanggo cyp2c8 lan CYP2J2 yaiku 4,82 μ M lan 5,75 μ M.
Kategori sing relevan:
Jalur sinyal > > enzim metabolik / protease > > sitokrom P450
Bidang riset > > kanker
Produk Alami > > liyane
Target:
CYP2C8: 4,82 μM (Ki)
CYP2J2: 5,75 μM (Ki)
Sinau In Vitro:
Asam Salvianolic C minangka inhibitor campuran moderat saka inhibitor cyp2c8 non-kompetitif lan CYP2J2.KIS cyp2c8 lan CYP2J2 masing-masing 4,82 lan 5,75 μ M[1]. 1 lan 5 μ M salvianolic acid C (SALC) bisa nyandhet produksi LPS sing ora ana produksi.Asam Salvianolic C nyuda ekspresi iNOS kanthi signifikan.Salvianolic acid C nyegah LPS induced TNF-α, IL-1 β, IL-6 lan IL-10 padha overproduced.Asam Salvianolic C nyegah aktivasi NF-κ B sing diakibatake LPS.Salvianolic acid C uga nambah ekspresi Nrf2 lan HO-1 ing BV2 microglia [2].
Ing Vivo Studies:
Salvianolic acid C (20mg / kg) perawatan Ngartekno suda latensi uwal.Kajaba iku, perawatan SALC (10 lan 20 mg / kg) kanthi signifikan nambah jumlah lintasan platform dibandhingake karo klompok model LPS.Dibandhingake karo klompok model, administrasi sistemik asam salvianolic C mudhun diatur otak TNF-α, IL-1 β Lan IL-6 tingkat.Tingkat iNOS lan COX-2 ing korteks serebral lan hippocampus tikus luwih dhuwur tinimbang ing klompok kontrol, dene perawatan asam salvianolic C sacara signifikan mudhun ing korteks lan hippocampus.Pangobatan asam salvianolic C (5, 10 lan 20 mg / kg) nambah tingkat p-ampk, Nrf2, HO-1 lan NQO1 ing korteks serebral tikus lan hippocampus kanthi cara gumantung dosis [2].
Referensi:
[1].Xu MJ, et al.Efek Inhibitory komponen Danshen ing CYP2C8 lan CYP2J2.Chem Biol Interaksi.1 Juni 2018;289:15-22.
[2].Song J, et al.Aktivasi sinyal Nrf2 dening asam salvianolic C attenuates respon inflamasi mediated NF κ B ing vivo lan in vitro.Int Immunopharmacol.2018 Okt;63:299-310.
