3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Applicatio Methylnissolin
Methylnisolin (astrapterocarpan) ab Astragalo membranaceo remotum et cellulam multiplicationem inhibere potest, inducta a factore inaurato (PDGF) - BB, cum IC50 inter 10 μ M。 Methylnisolin vetat phosphorylationem insignem extracellularem regularem kinasum 1 / 2 (eric1 / 2) interdum mitogen reducitur (map) kinase adductus PDGF-BB.Methylnisolin vetat PDGF-BB inductam multiplicationem cellularum musculorum vascularium laevium inhibendo ERK1 / 2 MAP cascades kinasi.
Nomen Methylnissolin
Nomen anglicum:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Seres Alias: 3-hydroxy-9,10-dimethoxy rubri sandalii |Astragalus ruber
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy rubra sandalwood
Actio biologica de Methylnissolin
Description: methylnisolin (astrapterocarpan) semotus ab Astragalo membranaceus
et inhibere cellulam multiplicationem inductam per factorem plagulae-incrementorum (PDGF) - BB.
IC50 est 10 μ M。 Methylnisolin vetat phosphorylationem signo extracellulari
kinase regulari 1 / 2 (eric1 / 2) mitogen reducitur interdum
PDGF-BB.Methylnisolin vetat PDGF-BB multiplicationem glabrorum vascularium inductam
cellulae musculi inhibentes ERK1/2 MAP kinasum cascades.
Related Categoriae: campus investigationis > > morbus cardiovascularis
iter > > interdum tyrosine kinase > > PDGFR
iter signum > > MAPK/ERK signum iter > > ERK
tramitem signans > > cellas caulis et callem Wnt > > ERK
Traget: PDGFR: 10 μM (IC50)
ERK1
ERK2
Relatio: [1].Ohkawara S, et al.Astrapterocarpana solitaria ab Astragalo membranaceo vetat multiplicatio vascularium cellularum musculorum laevium.Eur J Pharmacol.2005 Nov. 21, 525(1-3):41-7.
Proprietates Physicochemicae de Methylnissolin
Densitas: 1.3 ± 0.1 g / cm3
Fervens Point: 428.9 ± 45.0 ° C ad 760 mmHg
Formulae hypotheticae: c17h16o5
Pondus hypotheticum: 300.306
Flash Point: 213.2 ± 28.7 ° C
Missam accuratam: 300.009762
PSA:57.15000
LogP:2.45
Vapor Pressura: 0.0 ± 1.1 mmHg in 25° C
Index refractivus: 1.612
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