Neohesperidin
Synephrine hydrochloride
Neohesperidin est genus compositi flavonoidei, quod late in plantis Cucurbitaceis exstat et effectus antioxidantis et anti-inflammatoriis habet./h2>
Nomen Neohesperidin
Nomen anglicum: neohesperidin
Chinese Alias: neohesperidin |neohesperidin
Bioactivity of Neohesperidin
Descriptio: neohesperidin est compositum flavonoidum in Cucurbitaceis repertum, quod effectus antioxidantis et anti-inflammatoriis habet.
Genera Related: iter signum > > alia > > alia
investigationes campi > > inflammatio / immunitas
naturalis Products >> flavonoids
In Vitro Study:
Nova hesperidin inducit apoptosin in cancro pectoris humano MDA-MB-231 cellulis.Valores neohesperidini IC50 ad 24 et 48 horas erant 47.4 ± 2.6, respective µ M et 32.5 ± 1.8 µ M。 Expressio p53 et Bax in cellulis neohesperidin tractatis signanter ordinatis fuit, dum expressio Bcl-2 erat. temperare [1].Neohesperidin actio antioxidantis in DPPH testium radicalium scaenantium ostendit (IC50 = 22.31 μ g/mL）[2]。
In Vivo Study: neohesperidin (50mg / kg) insigniter obstat 55.0% HCl / ethanol gastrica iniuria inducta.In pylorus ligato mures inclusi, neohesperidin (50 mg / kg) secretionem gastrici signanter imminutam et acidi gastrici output et auctum pH [1].Neohesperidin curatio ieiunis sanguinem glucosum, sanguinem glucosum et serum interdum (GSP) in muribus insigniter imminutum.Glucosum oris signanter tolerantia et insulinum sensitivum augetur, et resistentia in diabetico muribus insulinis imminuitur.Neohesperidin signanter reducta serum triglycerides, cholesterolum totalis, leptin gradus et index hepatis in muribus [3].
Experimentum animale: mures: omnes mures ante experimentum 6 horis ieiunaverunt, et tunc aqua vel neohesperidin magnis pascuis alebantur.Nam OGTT et ITT, mures intraperitonee injecti sunt cum 2G/kg BW glucoso seu 1iu/kg BW insulino, respective.Specimina sanguinis ex vena caudalis collecta sunt ut gradus glucosi basalis sanguinis metirentur (0 minuta) ante injectionem glucosi vel insulini.GLYCOSA sanguine addito graduum XXX, 60, 90 et 120 minuta mensurata sunt [3].
Relatio: [1].Lee JH, et al.Effectus tutelae neohesperidin et poncirin a fructibus Poncirus trifoliatae in morbo gastrico potentiale separatae.Phytother Res.2009 Dec;
[2].Xu F, et al.Neohesperidin cellulosam apoptosin in pectore humano adenocarcinoma MDA-MB-231 inducit cellulas per viam activum Bcl-2/Bax mediatum significans.Nat Prod Communi.2012 Nov; 7 (11): 1475-8.
[3].Jia S, et al.Hypoglycemici et hypolipidemici effectus neohesperidini ex Citro aurantium L. in diabetico KK-A(y) murium.Cibus Funct.2015 Mar;6(3):878-86.
Physicochemical Properties De Neohesperidin
Densitas: 1.7 ± 0.1 g / cm3
Fervens punctum: 933.7 ± 65.0 ° C ad 760 mmHg
Exustio Point: 239-243 C
Formulae hypotheticae: C28H34O15
Pondus hypotheticum: 610.561
Flash Point: 306.7 ± 27.8 ° C
Missa Exacta: 610.189758
PSA:234.29000
LogP:2.44
Aspectus: 0.0 ± 0.3 mmHg ante 25° C
Vapor Pressura: 0.0 ± 0.3 mmHg in 25° C
Index refractivus: 1.695
Repono Conditiones: 2-8 ° C
Nova Hesperidin Information Salutis
Personalis armorum tutela: eyeshields;Gloves;typus N95 (US);type P1 (EN143) respirator filter
Salus Statement (Europe): s22-s24/25
Transporto codice periculosa bona: nonh omnibus modis onerariis
Wgk Germania: 3
RTECS No.: dj2981400
Neohesperidin Literature
Comparativa metabolicae et transcriptionalis analysis diploidis duplicatae eiusque diploidis caudice citri (C. junos cv. Ziyang xiangcheng) vim suam potentialem ad emendationem resistentiae accentus suggerit.
BMC Plant Biol.15, 89, (2015)
Polyploidy saepe consideratum est plantas conferre aptiorem adaptationem ad passiones environmentales.Tetraploides citri caudices putantur habere tolerantiam fortioris accentus quam diploidem.Copia...
Ougan (Citrus reticulata cv. Suavissima) flavedo extractum mobilitatem cancer supprimit impedito epitheliali-ad-mesenchymali transitus in cellulis SKOV3.
Mentum.Med.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) extractum flavedo (OFE) exhibitum potentiale anti-tumoris effectis cum mechanismis sub- obscuris.Hoc studium intendit aestimare acti potential anti-metastatici.
Hesperidin, nobiletin, et tangeretin collective responsabiles sunt pro capacitate anti-neuroinflammatoriae cortices tangerini (Citri reticulatae pericarpium).
Cibus Chem.Toxicol.71 , 176-82 .
Inhibentes neuroinflammationem microglialem activationem mediatam efficacem scopum factae sunt pro evolutione ciborum functionum ad morbos neurodegenerativos tractandos.Tangerine cortices (Citri reticulata...
Anglicus Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-unum, 7. -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S) -5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-unum, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2. -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
