Obtusin
Usus Obtusin
Obtusin, e semine casiae, inhibitor valde selectivus et auctorum monoamine humani generis oxidasi-A (hmao-a), cum IC50 ex 11.12 μ M. Ki est 6.15.Obtusin munus praeventivum agit in morbis neurodegenerativis, praesertim anxietatibus et tristitia.
Nomen Obtusin
Nomen anglicum: Obtusin
Bioactivity Obtusin
Descriptio: obtusin e semine casiae est.Inhibitor valde selectivus ac competitive monoamine oxidasi-A (hmao-a), cum IC50 ex 11.12 μ M. Ki 6.15 est.Obtusin munus praeventivum agit in morbis neurodegenerativis, praesertim anxietatibus et tristitia.
Related Categoriae: signum iter >> neural signum viae >> monoamine oxidase
Investigationes campi > > morbi neurologici
Target: IC50: 11.12 μ M (hMAO-A) [1] Ki: 6.15 (hMAO-A) [1]
Editio : [1] Paudel P, et al.In Vitro et in Silico Humani Monoamine Oxidase Inhibitoriae Potentiae Anthraquinonum, Naphthopyronum, et Lactonum Naphthalenicum ex Cassia obtusifolia Linn.ACS Omega.2019 Sep 18;4 (14):16139-16152.
Physicochemical Proprietates Obtusin
Densitas: 1.4 ± 0.1 g / cm3
Fervens Point: 614.9 ± 55.0 ° C ad 760 mmHg
Formulae hypotheticae: c18h16o7
Pondus hypotheticum: 344.315
Flash Point: 227.0 ± 25.0 ° C
Exacta Missa: 344.089600
PSA:102.29000
LogP:4.10
Vapor Pressura: 0.0 ± 1.8 mmHg in 25° C
Index refractivus: 1.634
Obtusin Safety Information
Consuetudines Codicis: 2914690090
Literature: Cameron, Donaldus W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetraedron Letters, 1986, vol.27, # 41 p.4999 - 5002
Obtusin Consuetudines
Consuetudines Codicis: 2914690090
Seres Overview: Chinese Overview
Summarium:2914690090 aliae quinones CURATIO: None VAT:17.0%。 Tax diminuitur rate: 9.0%。 MFN tariff:5.5%
Anglicus alias Consuetudines
9,10-Anthracenedione, 1,7-dihydroxy 2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinona.
Product Quality Control
1. Societas nuclearis resonantia magnetica acquisita (Bruker 400MHz) spectrometer, Phase liquidus massa spectrometer (LCMS), gas phase massa spectrometer (GCMs), massa spectrometri (aquae SQD), multiplex analytica latae analytica, chromatographa liquida perficiendi, chromatographa liquida praeparativa, etc. .
2. Societas arctam cooperationem et contactum cum Institutis investigationis scientificis conservat ut Shanghai Institutum ad medicamentorum regimen, biomedicum munus publicum Nanjing suggestum et analysis et centrum Shanghai pharmaceuticae Industry Research Institutum probat.
3. Societas laboratorium tertium-factum certificationis probationis active agit, et expectatur ut CNAs Laboratorium Accreditation certificatorium anno 2021 obtineat.
