Verbascoside CAS No
Notitia essentialis
[nomen]Mullein glycoside
[alias]ergosterol, Mullein
[genus]phenylpropanoid glycosides
[nomen Anglicum]Acteoside;Triticum aestivum;Kusaginin
[Molecular formula]C29H36O15
[pondus hypotheticus]624.59
[CAS No.]61276-17-3
Physica Properties
[Properties]Hoc productum est album acus crystallinum pulveris
[density relative]1.6g/cm3
[solubility]facile solutum in ethanolo, methanolo et ethylo acetate.
Extraction Source
Hoc productum est caulis carnosus siccus cum foliis squamosis Cistanche deserticolae, planta familiae liedang.
Test Methodi
HPLC ≥ 98%
Condiciones chromatographicae: mobile tempus methanolum acetonitrilum 1% aceticum aceticum (15:10:75), fluere rate 0.6 ml · min-1, columna temperatura 30℃, detectio necem 334 um (ad solam referentiam)
Munus et usus
This product is used for content determination
Ratio repono
2-8° C. reposita a luce.
Bioactivity de Verbascoside
In Vitro Study:
Pro competitive PKC Inhibitor ATP, Verbascoside IC50 ex 25 μ M。 Verbascoside habet kis 22 et 28 relativum cum ATP et histonum, respective μ M。 Verbascoside efficax antitumor actio in L-1210 cellulis cum IC50 of 13 μ M [1]。 Verbascosides (5,10) μ M) Inhibitio 2,4-dinitrochlorobenzeni (DNCB) - factores costimulatorii cellularum inductorum CD86 et CD54, cytokini proinflammatorii et NF in cellulis 1 κ κ B viae activationis [2].
In Vivo Studiorum:
Verbascosides (1%) incidentiam morum altiore scalpendi et acerbitas laesiones cutis in exemplar muris 2,4-dinitrochlorobenzene (DNCB) - dermatitis atopicis inductis (AD).Verbascosides etiam impediunt cytokinum pro-inflammatorium TNF in DNCB laesiones cutem inductam — α* elocutio IL-6, IL-4 variant [2].Verbascoside (50100 mg / kg, IP) frigus abnormes dolorem non mutavit ex iniuria compressiva chronica (CCI).Verbascoside (200 mg / kg, IP) allergia ad frigora acetona excitata reducitur in die 3. Verbascoside etiam significanter muta- tiones morum cum neuropathia coniungitur.Praeterea Verbascoside Bax redegit et auxit Bcl-2 die 3[3].
Experimentum cell:
mus lymphocyticus leukemia L1210 cellulae (ATCC, CCL 219) continebat serum bovinum foetus 10%, 4 mM glutamine, 100 U / ml penicillinum, 100 μ In 24 lamina bene botrus Dulbecco mutata aquila media, 104 cellulae per bene sparse positae/ Ml streptomycin sulfate et Verbascoside (in DMSO dissolutum).Augmentum monitum est per numerum cellularum in contra calculi computando post 2 dies incubationis in atmosphaera humida (5% CO2 in aere) ad 37 .Valor IC50 computabatur secundum regressionem linearem in linea pro compositis testiculis singulis constitutis [1].
Experimentum animale:
Ut atopic dermatitis (AD) - sicut symptomata, mures [2] utebantur 2,4-dinitrochlorobenzene (DNCB).Denique capillus dorsalis murium remotus est cum electronic forfice 2 diebus ante curationem DNCB.Voluntas 200 μ L of 1% DNCB (in acetone: oleum olivae = 4:1) adhibitum est ad cutem dorsi derasam ad sensum.Impetus iterati eodem situ fiebant, 0.2% DNCB omnes 3 dies circiter 2 septimanas.Mures in 4 partes divisae sunt (n = 6 in singulis gregibus): (1) vehiculum tractatum imperium, (2) DNCB tantum tractatum, (3) 1% Verbascoside (acetone: olivo 4i) - tantum tractata et ( 4) DNCB + 1% Verbascoside tractata natio[2].
Relatio:
[1].Herbert JM, et al.Verbascoside solitaria a Lantana camara, inhibitoris dapibus kinase C. J Nat Prod.1991 Nov-Dec;54(6):1595-600.
[2].Li Y, et al.Verbascoside lenit Atopic Dermatitis-Sicut Symptomata in Mice per Potentem Anti-inflammatorem Effectum.Int Arch Allergy Immunol.2018; 175(4):220-230.
[3].Amin B, et al.Effectus Verbascoside in Neuropathico dolore adductus per iniuriam Chronici constrictionis in carboribus.Phytother Res.2016 Ian;30(1):128-35.
