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Low price for Cas No.26575-95-1 - Isovitexin; Saponaretin; Homovitexin CAS No. 29702-25-8 – Yongjian

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Low price for Cas No.26575-95-1 - Isovitexin; Saponaretin; Homovitexin CAS No. 29702-25-8 – Yongjian Detail:

Essential Information

[Chinese name]: isovitexin

[Chinese alias]: isovitexin

[English name]: isovitexin

[English alias]:

6-( β- D-Glucopyranosyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

[CAS accession No.]: 29702-25-8

[molecular formula]: c21h20o10

[molecular weight]: 432.38

[source]: Ficus microphylla leaves

[properties]: yellow dry powder

[storage method]: – 4 ° C, keep away from light and dry

[precautions]: This product should be kept away from light, dry and low temperature Avoid product degradation caused by moisture and sunlight

[content determination method]: C18 column (150mm) × 4.6mm,5 μ m) The mobile phase was acetonitrile water acetic acid (22:78:1), the flow rate was 1.0ml/min, and the detection wavelength was 270nm.

[pharmacological use]: antitumor compound

[pharmacological properties] melting point: 228 ℃. Optical rotation[ α] D-7.9 ° (pyridine aqueous solution). Insoluble in cold water, slightly soluble in hot water and ethanol.

Biological Activity of Isovitexin

Target: JNK1 jnk2 NF- κ B

In vitro study: isovitexin prevents LPS induced oxidative damage by inhibiting the production of intracellular ROS, and also weakens the effect of H2O2 on cell viability. Contains LPS (2 μ Isovitexin (0-100 g / ml) μ G / ml) had no cytotoxicity to raw 264.7 cells, but 200 μ G / ml isovitexin showed significant cytotoxicity. Isovitexin (25,50) μ G / ml) inhibited LPS induced TNF- α, Increased levels of IL-6, iNOS and COX-2. Isovitexin (25,50) μ G / ml) also inhibited I in raw 264.7 cells κ B α Phosphorylation and degradation, which is consistent with the effect of JNK1 / 2 inhibitor [1].

In vivo studies: isovitexin (50 and 100 mg / kg, IP) caused less severe histopathological changes in lung sections and reduced the number of inflammatory cells in LPS induced mice. Heteroeosinophils (50 and 100 mg / kg, IP) decreased TNF by- α And IL-6 production, ROS production, MPO and MDA content, increased SOD and GSH, and prevented LPS induced inflammation and oxidative stress in LPS induced Ali mice. And effectively inhibit the protein expression of iNOS and COX-2 [1]. Isovitexin (25,50, 100 mg / kg) decreased the survival rate of LPS / D-gal induced liver injury in mice in a dose-dependent manner. Isovitexin also inhibited NF- κ B and up regulate LPS / D-gal induced Nrf2 and HO-1 in mice [2].

Cell experiment: cell viability was determined by MTT assay. Raw 264.7 cells were inoculated on 96 well plates (1) × 104 cells / well) and with various concentrations of isovitexin (final concentration: 0-200) μ G / ml) and LPS (2 μ G / ml) for 24 hours. In addition, use IV (25 or 50 μ G / ml) pretreated the cells for 1 hour, and then H 2O 2 (300) was added μ M)。 After 24 hours, MTT (5 mg / ml) was added to the cells and then incubated for 4 hours [1].

Animal experiment: mice [1] in order to establish Ali model, mice were randomly divided into 6 groups: control (saline), only isovitexin (100 mg / kg, dissolved in 0.5% DMSO), only LPS (0.5 mg / kg, dissolved in saline), LPS (0.5 mg / kg) + isovitexin (50 or 100 mg / kg) and LPS (0.5 mg / kg) + dexamethasone (DEX, 5 mg / kg, dissolved in saline). Isovitexin or DEX (5 mg / kg) isovitexin was administered. After exposure to isovitexin or DEX for 1 hour, mice were anesthetized with ether and LPS was administered intranasally (in) to induce lung injury. The animals were euthanized 12 hours after LPS administration. Therefore, bronchoalveolar lavage fluid (BALF) and lung tissue samples were harvested to measure cytokine levels; ROS generation; SOD, GSH, MDA and MPO activities; And the expression of COX-2, iNOS, HO-1 and Nrf2 proteins [1].


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Low price for Cas No.26575-95-1 - Isovitexin; Saponaretin; Homovitexin CAS No. 29702-25-8 –  Yongjian detail pictures

Low price for Cas No.26575-95-1 - Isovitexin; Saponaretin; Homovitexin CAS No. 29702-25-8 –  Yongjian detail pictures


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We stick to our enterprise spirit of "Quality, Performance, Innovation and Integrity". We purpose to create a lot more price for our prospects with our rich resources, innovative machinery, experienced workers and great products and services for Low price for Cas No.26575-95-1 - Isovitexin; Saponaretin; Homovitexin CAS No. 29702-25-8 – Yongjian , The product will supply to all over the world, such as: Croatia, Philippines, Riyadh, We've got constructed strong and long co-operation relationship with an enormous quantity of companies within this business in Kenya and overseas. Immediate and professional after-sale service supplied by our consultant group has happy our buyers. Thorough Info and parameters from the merchandise will probably be sent for you for any thorough acknowledge. Free samples may be delivered and company check out to our corporation. n Kenya for negotiation is constantly welcome. Hope to get inquiries type you and construct a long-term co-operation partnership.
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