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Low price for Cas No.480-10-4 - Isoliquiritin Apioside – Yongjian

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Application of Isoliquiritin Apioside

Isoliquiritin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.

Name of Isoliquiritin Apioside

Chinese Name: Isoliquiritin Apioside

English Name: (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one

Bioactivity of Isoliquiritin Apioside

Description: isoliquitin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.

Related Categories: research field > > cancer
Signal path > > MAPK / ERK signal path > > p38 MAPK
Signaling pathway > > metabolic enzyme / protease > > MMP

Target: MMP9
NF-κB
p38 MAPK

In vitro study: isorlicin could effectively inhibit the gelation MMP-9 activity of PMA induced HT1080 cells. Isoglycyrrhizin apigenin reduces the increase of MMP-9 production in HT1080 cells induced by PMA, has the ability of anti metastasis and anti angiogenesis in malignant tumor cells and endothelial cells, and has no cytotoxicity [1].

Reference: [1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.

Physicochemical properties of Isoliquiritin Apioside

Density: 1.6 ± 0.1 g / cm³

Boiling point: 901.0 ± 65.0 ° C at 760 mmHg

Molecular formula: c26h30o13

Molecular weight: 550.509

Flash point: 301.9 ± 27.8 ° C

Accurate mass: 550.168640

PSA:215.83000

LogP:1.96

Steam pressure: 0.0 ± 0.3 mmHg at 25 ° C

Refractive index: 1.709

English alias of Isoliquiritin Apioside

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-

3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside

Neolicuroside

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