Methylophiopogonanone A; Opogonanone A
Application of Methylophiopogonanone A
Methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has antioxidant and anti-inflammatory effects.
Name Of Methylophiopogonanone A
English Name:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Chinese Alias:
Ophiopogon methyl flavanone a | methyl Ophiopogon dihydrohomoisoflavone a | methyl Ophiopogon flavanone a
Biological Activity Of Methylophiopogonanone A
Description: methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has
antioxidant and anti-inflammatory effects.
Related Categories: signal pathway > > apoptosis > > apoptosis
research field > > inflammation / immunity
In Vitro Study: methyl aspartate a (mo-a; 10 μ Mo (L / L) significantly decreased apoptosis and Caspase-3 expression, increased Bcl-2 / Bax ratio and restored no production. Methylaspartate a (mo-a) pretreatment
significantly enhanced the activation of PI3K / Akt / eNOS pathway in H9c2 cells under H / R, while the protective effect of mo-a was cancelled in the presence of PI3K inhibitor wortmannin (100 nmol / L) [1].
In Vivo Study: protective effect of methylaspartate a (mo-a; 10mg / kg / D, PO) on cardiac function after myocardial I / R injury [1].
References: [1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun; 37(6):763-71.
Physicochemical properties Of Methylophiopogonanone A
Density: 1.4 ± 0.1 g / cm3
Boiling Point: 580.1 ± 50.0 ° C at 760 mmHg
Molecular Formula: c19h18o6
Molecular Weight: 342.343
Flash Point: 212.9 ± 23.6 ° C
Exact Mass: 342.110352
PSA:85.22000
LogP:5.16
Steam Pressure: 0.0 ± 1.7 mmHg at 25 ° C
Refractive Index: 1.654
English Alias Of Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
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