Methylophiopogonanone B
Application of Methylophiopogonanone B
Methylophiopogonone B, high isodihydroflavone, extracted from the root of Ophiopogon japonicus, has high antioxidant capacity. Methylophiopogonone B increases GTP Rho and acts through Rho signaling pathway. Methylophiopogonone B induces cell morphological changes, including dendritic contraction and stress fiber formation, through actin cytoskeleton reorganization.
Name Of Methylophiopogonanone B
English Name:
(3R)-5,7-Dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-2,3-dihydro-4 H-chromen-4-one
Biological activity of Methylophiopogonanone B
Description: methylophiopogonone B, high isodihydroflavone, extracted from the root of Ophiopogon japonicus, has high antioxidant capacity. Methylophiopogonone B increases GTP Rho and acts through Rho signaling pathway. Methylophiopogonone B induces cell morphological changes, including dendritic contraction and stress fiber formation, through actin cytoskeleton reorganization.
Related Categories: research field > > other
signaling pathway > > G protein coupled receptor /
G protein > > RAS
References: [1] Wang Y, et al. Homoisoflavonoids and the Antioxidant
Activity of Ophiopogon japonicus Root.
Ito Y, et al. A novel agent, methylophiopogonanone B,
promotes Rho activation and tubulin depolymerization. Mol Cell Biochem. 2007 Mar; 297(1-2):121-9. Epub 2006 Oct 7.
Physicochemical properties of Methylophiopogonanone B
Density: 1.285
Boiling Point: 554.5 ± 49.0 ° C at 760 mmHg
Molecular Formula: C19H20O5
Molecular weight: 328.359
Flash point: 201.5 ± 23.3 ° C
Exact mass: 328.131073
PSA：75.99000
LogP：5.22
Steam pressure: 0.0 ± 1.6 mmHg at 25 ° C
Refractive index: 1.617
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