Hua

Whakaahuatanga:Ko te glucoridin he isoflavane mai i te glycorrhiza glabra, ka taea te here me te whakahohe i te PPAR γ， Ko te uara EC50 he 6115 nm.Glabridin he antioxidant, antibacterial, anti glomerulonephritis, anti mate huka, anti-tumor, anti-inflammatory, anti osteoporosis, tiaki cardiovascular, tiaki i nga nerves, scavenge free radicals me etahi atu mahi.

Ngā Kāwai Pātahi:mara rangahau > > mate pukupuku
Ara tohu > > huringa pūtau / kino DNA > > PPAR
Te mara rangahau > > te mumura / mate mate

Akoranga In Vitro:Ko te glabridin te here me te whakahohe i te PPAR γ， EC50 he 6115 nm [1].Glabridin（40,80 μ M) Ko te tipu o te SCC-9 me nga raina pūtau SAS i aukatihia i roto i te horopeta me te wa e whakawhirinaki ana i muri i nga haora 24 me te 48 o te maimoatanga [2].Glabridin（0-80 μ M) Ka whakaawe hoki i te apoptosis, e arai atu ana ki te hopu i te huringa o te huringa pūtau G1 i roto i nga raina pūtau SCC-9 me SAS [2].Glabridin (0,20,40 me 80 μ M) Dose dependently activated Caspase-3, - 8 me - 9 me te whakanui ake i te wehenga PARP, tino phosphorylating ERK1 / 2, JNK1 / 2 me P-38 MAPK i SCC-9.Pūtau [2].

I roto i te Akoranga Vivo:Ko te glabridin (50 mg / kg, Po kotahi i ia ra) i whakaatu i te kaha o te mahi anti-inflammatory me te whakapai ake i nga huringa mumura i puta mai i te dextran sodium sulfate (DSS) [3]

Tohutoro:[1] Rebhun JF, et al.Ko te tautuhi i te glabridin hei pūhui koiora i roto i te raihana (Glycyrrhiza glabra L.) tangohanga e whakahohe ana i te gamma kaiwhakawhiwhi-whakahohe i te peroxisome proliferator-whakahohe (PPAR γ).Fitoterapia.2015 Oketopa;106:55-61.
[2].Chen CT, et al.Ko te Glabridin e whakaawe ana i te apoptosis me te hopu huringa pūtau i roto i nga pūtau mate pukupuku waha i roto i te huarahi tohu JNK1/2.Taiao Toxicol.2018 Hune;33(6):679-685.
[3].El-Ashmawy NE, et al.Ko te whakahekenga o te iNOS me te pikinga o te cAMP ka takawaenga i te paanga anti-inflammatory o te glabridin i roto i nga kiore me te ulcerative colitis.Inflammopharmacology.2018 Apr;26(2):551-559.