Isoliquiritin Apioside
Te tono mo te Isoliquiritin Apioside
Ko te Isoliquiritin apioside, he waahanga kua wehea mai i te glycorrhizae radio rhome, i tino whakaitihia te piki o te PMA i te mahi MMP9 me te aukati i te PMA i te MAPK me te NF-κ B whakahohe.Ko te Isoliquitin apioside te aukati i te whakaekenga me te angiogenesis o nga pūtau mate pukupuku me nga pūtau endothelial.
Ingoa o Isoliquiritin Apioside
Ingoa Hainamana:Isoliquiritin Apioside
Ingoa Ingarihi:(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Koioraora o Isoliquiritin Apioside
Whakaahuatanga:Ko te isoliquitin apioside, he waahanga kua wehea mai i te reo irirangi glycorrhizae rhome, i tino whakahekehia te whakanui ake o te PMA i roto i te mahi MMP9 me te aukati i te mahi a te PMA i te MAPK me te NF-κ B.Ko te Isoliquitin apioside te aukati i te whakaekenga me te angiogenesis o nga pūtau mate pukupuku me nga pūtau endothelial.
E pa anaCkāwai:mara rangahau > > mate pukupuku
Ara tohu > > ara tohu MAPK / ERK > > p38 MAPK
Te ara tohu > > metabolic enzyme / protease > > MMP
Whainga:MMP9
NF-kB
p38 MAPK
Te ako in vitro:Ka taea e te isorlicin te aukati i te mahi MMP-9 o nga pūtau HT1080 na te PMA.Ko te Isoglycyrrhizin apigenin ka whakaiti i te pikinga o te hanga MMP-9 i roto i nga pūtau HT1080 na te PMA, he kaha ki te anti metastasis me te anti angiogenesis i roto i nga pukupuku pukupuku kino me nga pūtau endothelial, a kaore he cytotoxicity [1].
Tohutoro:[1].Kim A1, et al.Ko te Isoliquiritin Apioside ka whakakore i te Invasiveness in vitro me te Angiogenesis o nga Pūtau Mate pukupuku me nga Endothelial Cells.Front Pharmacol.2018 Hakihea 10;9:1455.
Nga ahuatanga matū-a-tinana o Isoliquiritin Apioside
Kiato: 1.6 ± 0.1 g / cm3
Kohuatanga: 901.0 ± 65.0 ° C i te 760 mmHg
tātai rāpoi: c26h30o13
Te taumaha ngota: 550.509
Ira hiko: 301.9 ± 27.8 ° C
Papatipu tika: 550.168640
PSA:215.83000
RangitakiP:1.96
Te pehanga mamaoa: 0.0 ± 0.3 mmHg i te 25 ° C
Taupū Reractive: 1.709
Ko te ingoa Ingarihi o Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
