Obtusin
Te whakamahi o Obtusin
Ko te Obtusin, mai i te purapura cassia, he tino whiriwhiri me te whakataetae whakataetae o te tangata monoamine oxidase-A (hmao-a), me te IC50 o 11.12 μ M. Ki te 6.15.Ka whai waahi a Obtusin ki te aukati i nga mate neurodegenerative, ina koa te awangawanga me te pouri.
Ingoa o Obtusin
Ingoa Ingarihi: Obtusin
Te koiora o Obtusin
Whakaahuatanga: Ko te obtusin no te kakano cassia.He tino whiriwhiri me te whakataetae whakataetae o te tangata monoamine oxidase-A (hmao-a), me te IC50 o 11.12 μ M. Ki te 6.15.Ka whai waahi a Obtusin ki te aukati i nga mate neurodegenerative, ina koa te awangawanga me te pouri.
Nga waahanga e pa ana: ara tohu > > ara tohu neural > > monoamine oxidase
Te mara rangahau > > mate neurological
Whāinga: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Tohutoro: [1] Paudel P, et al.In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds.ACS Omega.2019 Hepetema 18;4(14):16139-16152.
Nga ahuatanga matū o Obtusin
Kiato: 1.4 ± 0.1 g / cm3
Kohuatanga: 614.9 ± 55.0 ° C i te 760 mmHg
Tātai rāpoi: c18h16o7
Taumaha rāpoi: 344.315
Ira Kohiko: 227.0 ± 25.0 ° C
Papatipu Tika: 344.089600
PSA:102.29000
RangitakiP:4.10
Te Peehanga Maamaa: 0.0 ± 1.8 mmHg i te 25 ° C
Taurangi Whakaata: 1.634
Nga korero haumaru o Obtusin
Waehere Tikanga: 2914690090
Tuhituhi: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Letters, 1986, vol.27, # 41 p.4999 - 5002
Obtusin Customs
Waehere Tikanga: 2914690090
Tirohanga Hainamana: Tirohanga Hainamana
Whakarāpopototanga:2914690090 atu quinones. Tikanga tirotiro:Karekau
Ingoa Ingoa o Nga Tikanga
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Mana Kounga Hua
1. I hokona e te kamupene te irirangi autō karihi (Bruker 400MHz), te inenga o te wahanga wai (LCMS), te irirangi papatipu hau (GCMs), te inenga papatipu (Wai SQD), te maha o nga tātaritanga aunoa o nga chromatograph wai mahi teitei, nga chromatographs wai whakarite, etc .
2. Ka mau tonu te mahi tahi a te kamupene me te whakapiri atu ki nga whare rangahau pūtaiao penei i te Shanghai Institute mo te whakahaere tarukino, Nanjing biomedical public service platform me te tātari me te pokapū whakamatautau o Shanghai Pharmaceutical Industry Research Institute.
3. Kei te kaha te kamupene ki te kawe i nga tiwhikete whakamatautau taiwhanga tuatoru, me te tumanako ka whiwhi Tiwhikete Whakamana Taiwhanga CNA i te tau 2021.
