Te waikawa Salvianolic C
Te kaupapa
Ko te waikawa Salvianolic C he aukati whakataetae kore o te cytochrome p4502c8 (cyp2c8) me te aukati whakauru o te cytochrome P4502J2 (CYP2J2) me te kaha reo.Ko ona uara Ki mo cyp2c8 me CYP2J2 he 4.82 μ M me te 5.75 μ M
Ingoa Ingarihi
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) waikawa propanoic
Ingoa Ingoa
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) waikawa propanoic
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) waikawa propanoic
Te waikawa Benzenepropanoic, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Te waikawa Salvianolic C
Nga Ahuatanga A-tinana o te Waikawa Salvianolic C
Kiato: 1.6 ± 0.1 g / cm3
Kohuatanga: 844.2 ± 65.0 ° C i te 760 mmHg
Tātai rāpoi: C26H20O10
Taumaha rāpoi: 492.431
Ira hiko: 464.4 ± 34.3 ° C
Papatipu Tika: 492.105652
PSA:177.89000
RangitakiP: 3.12
Te Peehanga Maamaa: 0.0 ± 3.3 mmHg i te 25 ° C
Taupū Reractive: 1.752
Koiaora o te Waikawa Salvianolic C
Whakaahuatanga:
Ko te waikawa Salvianolic C he aukati whakataetae kore o te cytochrome p4502c8 (cyp2c8) me te aukati whakauru o te cytochrome P4502J2 (CYP2J2) me te kaha reo.Ko ona uara Ki mo cyp2c8 me CYP2J2 he 4.82 μ M me te 5.75 μ M.
Ngā kāwai hāngai:
Te ara tohu > > te enzyme metabolic / protease > > cytochrome P450
Te mara rangahau > > mate pukupuku
Hua Taiao > > etahi atu
Whāinga:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Akoranga In Vitro:
Ko te waikawa Salvianolic C he aukati whakauru ngawari o te aukati cyp2c8 kore whakataetae me te CYP2J2.Ko te KIS o te cyp2c8 me te CYP2J2 he 4.82 me te 5.75 μ M[1] 。 1 me te 5 μ M waikawa salvianolic C (SALC) ka taea te aukati i te LPS i te kore hanga.Ko te waikawa Salvianolic C i tino whakahekehia te korero o te iNOS.Ko te waikawa Salvianolic C ka aukati i te LPS i whakaawehia te TNF-α, IL-1 β, IL-6 me IL-10 he nui rawa te whakaputa.Ko te waikawa Salvianolic C ka whakakore i te LPS i whakaawehia te NF- κ B whakahohe.Ko te waikawa Salvianolic C i whakanui ake i te korero o Nrf2 me HO-1 i roto i te BV2 microglia [2].
I roto i nga Akoranga Vivo:
Ko te maimoatanga o te waikawa Salvianolic C (20mg / kg) i tino whakahekehia te roanga mawhiti.I tua atu, ko te maimoatanga SALC (10 me te 20 mg / kg) i tino piki ake te maha o nga whakawhitinga papaa whakaritea ki te roopu tauira LPS.Ka whakatauritea ki te roopu tauira, ko te whakahaere punaha o te waikawa salvianolic C ki raro ka whakahaerea te roro TNF-α， IL-1 β Me te IL-6 taumata.Ko nga taumata o te iNOS me te COX-2 i roto i te cerebral cortex me te hippocampus o te kiore he teitei ake i era i roto i te roopu whakahaere, i te mea ko te maimoatanga o te waikawa salvianolic C i tino heke te whakahaere i te cortex me te hippocampus.Ko te waikawa Salvianolic C (5, 10 me te 20 mg / kg) i piki ake te maimoatanga p-ampk, Nrf2, HO-1 me NQO1 i roto i te kiore cerebral cortex me te hippocampus i roto i te tikanga horopeta-ti'aturi [2].
Tohutoro:
[1].Xu MJ, et al.Nga Paanga aukati o nga wahanga Danshen i runga i te CYP2C8 me te CYP2J2.Chem Biol Interact.2018 Hune 1;289:15-22.
[2].Waiata J, et al.Ko te whakahoahoatanga o te tohu Nrf2 na te waikawa salvianolic C ka whakaheke i te NF κ B te urupare inflammatory i roto i te vivo me te in vitro.Int Immunopharmacol.2018 Oketopa;63:299-310.
