Neohesperidin
Application of Synephrine Hydrochloride
Neohesperidin is a kind of flavonoid compound that exists widely in Cucurbitaceae plants and has antioxidant and anti-inflammatory effects./h2>
Name of Neohesperidin
English Name: neohesperidin
Chinese Alias: neohesperidin | neohesperidin
Bioactivity of Neohesperidin
Description: neohesperidin is a flavonoid compound found in Cucurbitaceae, which has antioxidant and anti-inflammatory effects.
Related categories: signal path > > other > > other
research field > > inflammation / immunity
natural Products > > flavonoids
In Vitro Study:
New hesperidin induces apoptosis in human breast cancer MDA-MB-231 cells. The IC50 values of neohesperidin at 24 and 48 hours were 47.4 ± 2.6, respectively μ M and 32.5 ± 1.8 μ M。 The expression of p53 and Bax was significantly up-regulated in neohesperidin treated cells, while the expression of Bcl-2 was down regulated [1]. Neohesperidin showed antioxidant activity in DPPH radical scavenging test (IC50 = 22.31 μ g/ mL）[2]。
In Vivo Study: neohesperidin (50mg / kg) significantly inhibited 55.0% HCl / ethanol induced gastric injury. In pylorus ligated rats, neohesperidin (50 mg / kg) significantly reduced gastric secretion and gastric acid output and increased pH [1]. Neohesperidin treatment significantly reduced fasting blood glucose, blood glucose and glycosylated serum protein (GSP) in mice. It significantly increased oral glucose tolerance and insulin sensitivity, and reduced insulin resistance in diabetic mice. Neohesperidin significantly reduced serum triglycerides, total cholesterol, leptin levels and liver index in mice [3].
Animal Experiment: mice: All mice fasted 6 hours before the test, and then were fed with water or neohesperidin by forced feeding. For OGTT and ITT, mice were injected intraperitoneally with 2G / kg BW glucose or 1iu / kg BW insulin, respectively. Blood samples were collected from the caudal vein to measure basal blood glucose levels (0 minutes) before injection of glucose or insulin. Additional blood glucose levels were measured at 30, 60, 90 and 120 minutes [3].
Reference:[1]. Lee JH, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23(12):1748-53.
[2]. Xu F, et al. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Nat Prod Commun. 2012 Nov;7(11):1475-8.
[3]. Jia S, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food Funct. 2015 Mar;6(3):878-86.
Physicochemical Properties Of Neohesperidin
Density: 1.7 ± 0.1 g / cm3
Boiling Point: 933.7 ± 65.0 ° C at 760 mmHg
Melting Point: 239-243 º C
Molecular Formula: C28H34O15
Molecular Weight: 610.561
Flash Point: 306.7 ± 27.8 ° C
Exact Mass: 610.189758
PSA:234.29000
LogP:2.44
Appearance: 0.0 ± 0.3 mmHg at 25 ° C
Steam Pressure: 0.0 ± 0.3 mmHg at 25 ° C
Refractive Index: 1.695
Storage Conditions: 2-8 ° C
New Hesperidin Safety Information
Personal protective equipment: eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter
Safety Statement (Europe): s22-s24 / 25
Transport code of dangerous goods: nonh for all modes of transport
Wgk Germany: 3
RTECS No.: dj2981400
Neohesperidin Literature
Comparative metabolic and transcriptional analysis of a doubled diploid and its diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) suggests its potential value for stress resistance improvement.
BMC Plant Biol. 15 , 89, (2015)
Polyploidy has often been considered to confer plants a better adaptation to environmental stresses. Tetraploid citrus rootstocks are expected to have stronger stress tolerance than diploid. Plenty of...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells.
Chin. Med. 10 , 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) exhibited potential anti-tumor effects with unclear underlying mechanisms. This study aims to evaluate the potential anti-metastatic acti...
Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).
Food Chem. Toxicol. 71 , 176-82, (2014)
Inhibiting microglial activation-mediated neuroinflammation has become a convincing target for the development of functional foods to treat neurodegenerative diseases. Tangerine peel (Citri reticulata...
English Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
