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Newly Arrival 5-O-Methylvisamminol - Calycosin CAS No. 20575-57-9 – Yongjian

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Newly Arrival 5-O-Methylvisamminol - Calycosin CAS No. 20575-57-9 – Yongjian Detail:

Essential Information

[name] Mullein glycoside

[alias] ergosterol, Mullein

[category] phenylpropanoid glycosides

[English name] acteoside; Verbascoside; Kusaginin

[molecular formula] C29H36O15

[molecular weight] 624.59

[CAS No.] 61276-17-3

Physicochemical Properties

[properties] this product is white needle crystal powder

[relative density] 1.6g/cm3

[solubility] easily soluble in ethanol, methanol and ethyl acetate.

Extraction Source

This product is the dry fleshy stem with scaly leaves of Cistanche deserticola, a plant of liedang family.

Test Method

HPLC ≥ 98%

Chromatographic conditions: mobile phase methanol acetonitrile 1% acetic acid (15:10:75), flow rate 0.6 ml · min-1, column temperature 30 ℃, detection wavelength 334 nm (for reference only)

Function and Use

This product is used for content determination

Storage Method

2-8 ° C, stored away from light.

Bioactivity of Verbascoside

In Vitro Study:
As a competitive PKC Inhibitor of ATP, Verbascoside has an IC50 of 25 μ M。 Verbascoside showed kis of 22 and 28 relative to ATP and histone, respectively μ M。 Verbascoside has effective antitumor activity on L-1210 cells with IC50 of 13 μ M[1]。 Verbascoside (5,10) μ M) Inhibition of 2,4-dinitrochlorobenzene (DNCB) – induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines and NF in thk-1 cells κ B pathway activation [2].

In Vivo Studies:
Verbascoside (1%) reduced the incidence of overall scratching behavior and the severity of skin lesions in a mouse model of 2,4-dinitrochlorobenzene (DNCB) – induced atopic dermatitis (AD). Verbascoside can also block the pro-inflammatory cytokine TNF in DNCB induced skin lesions- α, Expression of IL-6 and IL-4 mRNA [2]. Verbascoside (50100 mg / kg, IP) did not change the cold abnormal pain caused by chronic compressive injury (CCI). Verbascoside(200 mg / kg, IP) reduced allergy to cold stimulated acetone on day 3. Verbascoside also significantly reduced the behavioral changes associated with neuropathy. In addition, Verbascoside reduced Bax and increased Bcl-2 on day 3 [3].

Cell Experiment:
lymphocytic mouse leukemia L1210 cells (ATCC, CCL 219) contained 10% fetal bovine serum, 4 mM glutamine, 100 U / ml penicillin, 100 μ In the 24 well cluster plate of Dulbecco modified Eagle medium, 104 cells per well were sparsely laid/ Ml streptomycin sulfate and Verbascoside (dissolved in DMSO). Growth was monitored by counting the number of cells in the Coulter counter after 2 days of incubation in a humid atmosphere (5% CO2 in air) at 37 ℃. The IC50 value was calculated based on the linear regression line established for each test compound [1].

Animal Experiment:
In order to induce atopic dermatitis (AD) – like symptoms, rats [2] used 2,4-dinitrochlorobenzene (DNCB). In short, the dorsal hair of mice was removed with electronic scissors 2 days before DNCB treatment. Will 200 μ L of 1% DNCB (in acetone: olive oil = 4:1) was applied to shaved back skin for sensitization. Repeated attacks were performed at the same site, 0.2% DNCB every 3 days for about 2 weeks. Mice were divided into 4 groups (n = 6 in each group): (1) vehicle treated control, (2) DNCB treated only, (3) 1% Verbascoside (acetone: olive oil 4:1) – treated only, and (4) DNCB + 1% Verbascoside treated group[2].

Reference:
[1]. Herbert JM, et al. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600.
[2]. Li Y, et al. Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti-Inflammatory Effect. Int Arch Allergy Immunol. 2018;175(4):220-230.
[3]. Amin B, et al. The Effect of Verbascoside in Neuropathic Pain Induced by Chronic Constriction Injury in Rats. Phytother Res. 2016 Jan;30(1):128-35.


Product detail pictures:

Newly Arrival  5-O-Methylvisamminol  - Calycosin CAS No. 20575-57-9 –  Yongjian detail pictures

Newly Arrival  5-O-Methylvisamminol  - Calycosin CAS No. 20575-57-9 –  Yongjian detail pictures


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Our target should be to consolidate and enhance the top quality and service of current goods, in the meantime frequently create new products to satisfy diverse customers' calls for for Newly Arrival 5-O-Methylvisamminol - Calycosin CAS No. 20575-57-9 – Yongjian , The product will supply to all over the world, such as: Bolivia, California, Italy, Our company will continue to serve customers with best quality, competitive price and timely delivery & the best payment term! We sincerely welcome friends from all over the world to visit& cooperate with us and enlarge our business. If you are interested in our products, please do not hesitate to contact us, we will be happy to provide you with further information!
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