Astragaloside IV CAS No. 84687-43-4
Mawu Oyamba Mwachidule
Dzina la Chingerezi:Astragaloside IV;beta-D-Glucopyranoside, (3beta, 6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Molecular Formula:C41H68O14
Dzina la Chemical:17- [5- (1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D-glucoside
Mp:200 ~ 204 ℃
[α]D:-56.6 (c,0.13 mu DMF)
UV:λmax203 nm
chiyero:98%
Gwero:nyemba za Astragalus membranaceus, Astragalus pubescens.
Chemical kapangidwe ka astragaloside IV
Physicochemical Properties
[mawonekedwe]:woyera crystalline ufa
[kuyera]:pamwamba 98%, njira yodziwira: HPLC
[chomera]:mizu ya Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Bungede mizu, Astragalus sieversianus Pall Muzu wa Astragalus spinosus Vahl, mbali yamlengalenga ya Astragalus spinosus Vahl.
[Katundu wazinthu]:Astragalus membranaceus Tingafinye ndi bulauni chikasu ufa.
[kutsimikiza kwa zomwe zili]:kudziwa ndi HPLC (Zowonjezera VI D, Volume I, Chinese Pharmacopoeia, Edition 2010).
Chromatographic situation and system applicability test} octadecyl silane bonded silica gel amagwiritsidwa ntchito ngati filler, acetonitrile water (32:68) amagwiritsidwa ntchito ngati gawo la mafoni, ndipo chowunikira chomwaza kuwala chimagwiritsidwa ntchito kuti chizindikirike.Chiwerengero cha mbale zongoyerekeza sichiyenera kuchepera 4000 malinga ndi nsonga ya astragaloside IV.
Kukonzekera yankho lachidziwitso, tengani kuchuluka koyenera kwa astragaloside IV, kuyeza molondola, ndikuwonjezera methanol kukonzekera yankho lomwe lili ndi 0.5mg pa 1ml.
Kukonzekera yankho la mayeso:tengani pafupifupi 4G ya ufa kuchokera ku mankhwalawa, muyese bwino, ikani mu Soxhlet extractor, onjezerani 40ml wa methanol, zilowerereni usiku wonse, kuwonjezera mlingo woyenera wa methanol, kutentha ndi reflux kwa maola 4, bwezeretsani zosungunulira kuchokera muzitsulo ndikuyika maganizo. kuti ziume, onjezerani 10ml ya madzi kuti musungunuke zotsalira, gwedezani ndikuzichotsa ndi n-butanol yodzaza kwa 4 nthawi, 40ml nthawi iliyonse, phatikizani yankho la n-butanol, ndikusambitsa kwathunthu ndi yankho la ammonia kwa nthawi ziwiri, 40ml iliyonse. nthawi, kutaya yankho la ammonia, sungunulani yankho la n-butanol, onjezerani 5ml madzi kuti musungunule zotsalira, ndikuziziritsa, Kupyolera mu mzere wa D101 macroporous adsorption resin (m'mimba mwake: 37.5px, kutalika kwa mzere: 300px), lote ndi 50ml yamadzi , kutaya njira yamadzi, perekani ndi 30ml ya 40% ethanol, kutaya zotsalira, 80ml 80ml ya 70% ethanol, sonkhanitsani zowonongeka, muzizivumbulutse kuti ziume, sungunulani zotsalira ndi methanol, tumizani ku botolo la volumetric 5ml, kuwonjezera methanol pamlingo, gwedezani bwino, ndindiye zipezeni.
Njira yotsimikizira:kuyamwa molondola 10% ya yankho lofotokozera motsatana μ l, 20 μ l.Njira yoyesera 20 iliyonse μl.Ibayeni mu chromatograph yamadzimadzi, izindikireni, ndikuwerengera ndi logarithm equation ya njira yakunja ya mfundo ziwiri.
Zowerengedwa ngati zowuma, zomwe zili mu astragaloside IV (c41h68o14) sizikhala zosachepera 0.040%
Pharmacological Action
Zigawo zazikulu za Astragalus ndi polysaccharides ndi astragaloside.Astragaloside imagawidwa kukhala astragaloside I, astragaloside II ndi astragaloside IV.Mwa iwo, astragaloside IV, astragaloside IV, ali ndi ntchito yabwino kwambiri yachilengedwe.Astragaloside IV sikuti imakhala ndi zotsatira za Astragalus polysaccharides, komanso zotsatira zina zosayerekezeka za Astragalus polysaccharides.Mphamvu yake yogwira ntchito ndiyoposa kawiri kuposa ya astragalus polysaccharides wamba, ndipo mphamvu yake yoletsa ma virus ndi nthawi 30 kuposa ya Astragalus polysaccharides.Chifukwa cha kuchepa kwake komanso zotsatira zake zabwino, amadziwikanso kuti "super astragalus polysaccharide".
1.Kuwonjezera chitetezo chokwanira komanso kukana matenda.
Ikhoza kuchotseratu matupi akunja omwe amalowa m'thupi, kulimbikitsa chitetezo chamthupi, chitetezo chamthupi komanso chosadziwika bwino, ndikuwongolera kukana kwa matenda m'thupi.Itha kulimbikitsa kupanga ma antibody, ndikuwonjezera kwambiri kuchuluka kwa ma antibodies omwe amapanga ma cell ndi mtengo wa hemolysis.Astragaloside IV imatha kusintha kwambiri mulingo wa kusintha kwa ma lymphocyte komanso mapangidwe a E-rosette a nkhuku zotetezedwa ndi coccidia.Ndi mphamvu activator wa monocyte macrophage dongosolo.Astragaloside IV imathanso kukonza makutidwe ndi okosijeni, GSH-Px ndi zochitika za SOD m'zigawo zoteteza thupi, ndikuwongolera chitetezo chamthupi komanso ntchito zowunika chitetezo chamthupi.
2. Antiviral zotsatira.
Mfundo yake sapha mavairasi oyambitsa: kulimbikitsa ntchito ya macrophages ndi T maselo, kuwonjezera chiwerengero cha E-mphete kupanga maselo, cytokines, kulimbikitsa kupatsidwa ulemu wa interleukin, ndi kupanga nyama thupi kutulutsa amkati interferon, kuti akwaniritse cholinga sapha mavairasi.Zotsatira zake zidawonetsa kuti chitetezo chonse cha astragaloside IV pa IBD chinali 98.33%, chomwe chingalepheretse ndikuchiza IBD, ndipo panalibe kusiyana kwakukulu poyerekeza ndi yankho lapamwamba la chitetezo chamthupi la dzira yolk.Astragaloside imatha kupititsa patsogolo ntchito ya ma enzymes a antioxidant m'thupi, kuchepetsa zomwe zili mu LP0, kuchepetsa kuwonongeka kwa mitundu ya okosijeni yokhazikika, motero kuchepetsa kuchuluka kwa anthu komanso kufa kwa MD.Iwo akhoza kusintha otsika chitetezo ntchito chifukwa chotupa, kulimbikitsa kutsegula kwa maselo chitetezo, kumasula amkati zinthu, ndi kupewa kupha ndi chopinga wa chotupa maselo chifukwa peroxidation;Astragaloside a imatha kulepheretsa kukula kwa kachilombo ka fuluwenza komanso ntchito ya sialidase.Zimakhala ndi zotsatira pa ntchito ya fuluwenza HIV cell nembanemba ndi adsorption ndi malowedwe a HIV kuti tcheru maselo.Kufa ndi kuyika kwa dzira kwa nkhuku kunachepetsedwa kwambiri, ndipo chiwerengero cha mazira oyika ndi chigoba cha mazira chinali bwino kwambiri kuposa gulu la amantadine lokha lolamulira, ndipo zotsatira za Astragalus polysaccharide sizinali zoonekeratu;Astragaloside IV ili ndi kupha mwamphamvu komanso zoletsa pa virus.Cholinga chake ndi chakuti kugwiritsa ntchito astragaloside IV kusanachitike kupezeka kwa matenda ndi kachilombo ka Nd, choncho ndi bwino kugwiritsa ntchito astragaloside IV kwa nthawi yaitali, Avian myeloblastic leukemia (AMB) 3 masiku AA broilers amadyetsedwa astragaloside IV ndi matenda. a AMB HIV, akhoza kuchepetsa incidence mlingo ndi kufa kwa AMB, kuonjezera LPO zili mu ziwalo zoteteza monga ndulu ndi thymus, kwambiri kumapangitsanso scavenging zotsatira za ndulu ndi thymus ndi ziwalo zina zoteteza pa myeloid linachokera chotupa maselo.Kachiwiri, astragaloside IV ili ndi zodziwikiratu zodzitetezera komanso zochizira pamatenda opumira monga matenda opatsirana a laryngotracheitis.Gwiritsani ntchito.
3. Anti stress effect.
Astragaloside IV imatha kuletsa adrenal hyperplasia ndi thymus atrophy munthawi yochenjeza ya kupsinjika, ndikuletsa kusintha kwachilendo kwanthawi yotsutsa komanso kulephera kwanthawi yoyankha kupsinjika, kuti athe kuchita nawo gawo loletsa kupsinjika, makamaka amakhala ndi njira ziwiri. zotsatira pa michere m`kati michere kagayidwe, ndipo amachepetsa ndi kuthetsa zotsatira za kutentha nkhawa pa zokhudza thupi ntchito ya thupi kumlingo wakuti.
4. Monga wolimbikitsa kukula.
Itha kupititsa patsogolo kagayidwe kachakudya m'maselo, kulimbikitsa kufalikira kwa magazi, kupititsa patsogolo kagayidwe kazakudya zam'thupi, komanso kukhala ndi thanzi komanso thanzi.Kafukufuku akuwonetsa kuti imatha kulimbikitsa kukula kwa bifidobacteria ndi lactic acid mabakiteriya ndipo imakhala ndi zotsatira za ma probiotics.
5. Astragaloside IV ikhoza kupititsa patsogolo ntchito ya mtima.
Limbitsani kugunda kwa mtima, tetezani myocardium ndikupewa kulephera kwa mtima.Imakhalanso ndi zotsatira zoteteza chiwindi, anti-inflammatory and analgesic.Itha kugwiritsidwa ntchito ngati chithandizo chothandizira matenda osiyanasiyana a ma virus ndi mabakiteriya.
