Cycloastragenol CAS No. 78574-94-4
Mafotokozedwe a Zamalonda
[Dzina]:cycloastragalus mowa
[mawu]:triterpenoid cyclic flavonol
[Dzina la Chingerezi]:cycloastragenol
[chilinganizo cha maselo]:C30H50O5
[kulemera kwa maselo]:490.71
[CAS No.]:78574-94-4
[njira yodziwira]:HPLC ≥ 98%
[Mafotokozedwe]:20mg 50mg 100mg 500mg 1g (akhoza mmatumba malinga ndi zofunika kasitomala)
[katundu]:chida ichi ndi colorless acicular crystal
[ntchito ndi ntchito]:Izi zimagwiritsidwa ntchito pozindikira zomwe zili, kuzindikiritsa, kuyesa zamankhwala, kuyesa zochitika ndi zoyeserera zina zasayansi.Monga ma cell administration, intragastric test, intragastric quality inspection of pharmaceutical factory, etc.Source: Astragalus membranaceus (Fisch.) Bge.Zouma mizu Tingafinye
Njira Yosungira
2-8 ° C, yosindikizidwa kuchokera ku kuwala ndikusungidwa kutentha kochepa.
Zindikirani
Izi ziyenera kusungidwa kutentha kochepa.Ngati ziwululidwa ndi mpweya kwa nthawi yayitali, zomwe zilimo zimachepetsedwa.
Chromatographic conditions} chromatographic column: Zorbax rx-c18 (4.6mm) × 150mm)，5 μ m; Mobile gawo: acetonitrile madzi (30:70);Mtengo woyenda: 1.0ml/mphindi, kutentha kwa mgawo: 35 ℃, magawo a ELSD: kutentha kwa chubu: 105 ℃, kuchuluka kwa nayitrogeni: 2.70ml/min.
Physicochemical katundu: kachulukidwe 1.20
Bioactivity ya cycloastragenol
Cycloastragalol ndi gulu la triterpene saponin, lomwe ndi Astragalus membranaceus (Fisch.) Hydrolyzate ya zomwe zimagwira mu Bunge).Astramembrangenin ili ndi chitetezo cha mkamwa ndipo imakhala ndi zotsatira zambiri za mankhwala, kuphatikizapo telomerase activation, telomere prolongation, anti-inflammatory and antioxidant properties.Astramembrangenin ali ndi anti-kukalamba katundu.CAG imalimbikitsa zochitika za telomerase mu ma keratinocyte akhanda aumunthu ndi maselo a mitsempha ya makoswe ndipo imapangitsa kuti CREB iyambe.Astramembrangenin ikhoza kukhala ndi chithandizo chatsopano pakukhumudwa
Magulu Oyenera:
Njira yolumikizira>> apoptosis>> apoptosis
Kafukufuku>> kutupa / chitetezo chokwanira
Munda wofufuza > > matenda a minyewa
Phunziro la In Vitro:
Poyerekeza ndi ulamuliro wonyamulira mu chikhalidwe HEK, nyenyezi membrane mapuloteni (0-10 μ M; 3-6 masiku) kuchuluka selo kukula [1].Astramembrangenin (0.3 μ M;Mphindi 5-90) idapangitsa CREB phosphorylation mu ma cortical neurons oyambira, ndipo mafotokozedwe a CREB onse m'ma cell onse sanakhudzidwe ndi CAG [1].Puloteni ya membrane ya nyenyezi (3) μ M;Maola a 6-48) amatha kulimbikitsa kusintha kwa ma vivo mu neurons, kuonjezera TERT mRNA mawu, ndikuwonetsa kuwonjezeka kwa bcl 2 mRNA mawu [1].Kuyesa kwa ma cell assay [1] cell line: HEK cell concentration: 1 μ M, 3 μ M, 10 μ M nthawi ya chikhalidwe: 3-6 masiku zotsatira: kukula kwa selo kuwirikiza kawiri pa masiku asanu ndi limodzi.Kusanthula kwa Western blot [1] cell line: neuron cell concentration: 0.3 μ M chikhalidwe nthawi: 5 mphindi, 15 mphindi, 30 mphindi, 90 mphindi.Zotsatira: CAG inachititsa CREB kutsegula mu neurons.RT-PCR [1] cell line: neuron cell concentration: 3 μ M nthawi ya chikhalidwe: 6-48 maola zotsatira: mawu a TERT ndi Bcl 2 mRNA akuwonjezeka.
Zolozera:
[1].Ip FC, ndi al.Cycloastragenol ndi mphamvu ya telomerase activator m'maselo a neuronal: zotsatira pakuwongolera kukhumudwa.Neurosignals.2014;22(1):52-63.
[2].Yu, ndi al.Cycloastragenol: Wolemba nkhani wosangalatsa wamatenda okhudzana ndi zaka.Exp Ther Med.2018 Sep; 16 (3): 2175-2182.
[3].Sun C, ndi al.Cycloastragenol imayimira kuyambitsa ndi kuponderezana kochulukira mu concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139.
Physicochemical katundu wa Cycloastragenol
Kachulukidwe:1.2 ± 0.1 g / cm3
Malo otentha:617.2 ± 55.0 ° C pa 760 mmHg
Malo osungunuka:241.0 mpaka 245.0 ° C
Molecular formula:c30h50o5
Kulemera kwa mamolekyu:490.715
Pophulikira:327.1 ± 31.5 ° C
Misa yeniyeni:490.365814
PSA:90.15000
LogP:3.82
Kuthamanga kwa Steam:0.0 ± 4.0 mmHg pa 25 ° C
Refractive index:1.582
Chidziwitso cha Chitetezo cha Cycloastragenol
Khodi yamayendedwe azinthu zoopsa: nonh pamayendedwe onse
Nambala ya RTECS;GX8265000
Customs Code: 2942000000
Cycloastragal Customs
Customs Code: 2942000000
Zolemba za Cycloastragalol
Cycloastragenol ndi mphamvu ya telomerase activator m'maselo a neuronal: zotsatira pakuwongolera kukhumudwa.
Neurosignals 22(1) , 52-63, (2014)
Cycloastragenol (CAG) ndi aglycone wa astragaloside IV.Idadziwika koyamba powunika zotulutsa za Astragalus membranaceus za zosakaniza zogwira ntchito zoletsa kukalamba.Maphunziro apano a ...
Novel telomerase activator imachepetsa kuwonongeka kwa mapapo mumtundu wa murine wa idiopathic pulmonary fibrosis.
PLoS ONE 8(3), e58423, (2013)
Kutuluka kwa matenda okhudzana ndi kusagwira ntchito bwino kwa telomere, kuphatikizapo Edzi, kuchepa kwa magazi m'thupi ndi pulmonary fibrosis, kwalimbikitsa chidwi chothandizira telomerase.Tikudziwitsani za n...
Telomerase-based pharmacologic kupititsa patsogolo kwa antivayirasi ntchito ya CD8+ T lymphocytes.
J. Immunol.181(10), 7400-6, (2008)
Telomerase reverse imalemba DNA ya telomere kumalekezero a ma chromosomes ozungulira ndikuletsa kukalamba kwa ma cell.Mosiyana ndi ma cell a somatic ambiri, omwe amawonetsa pang'ono kapena alibe zochita za telomerase, chitetezo ...
Dzina la Chingerezi la Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegegenin
