Galangin CAS No. 548-83-4
Thupi ndi mankhwala katundu
Dzinali:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Dzina la Chingerezi:galangin,
Dzina lachingerezi:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-imodzi
Kapangidwe ka Maselo
1. Molar refractive index: 69.55
2. Molar voliyumu (m3 / mol): 171.1
3. Voliyumu yeniyeni ya isotonic (90.2k): 519.4
4. Kuthamanga kwapamwamba (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Computational Chemistry
1. Kuwerengera kwa hydrophobic parameter calculation (xlogp): Palibe
2. Chiwerengero cha opereka ma hydrogen bond: 3
3. Chiwerengero cha ma hydrogen bond receptors: 5
4. Chiwerengero cha ma rotatable ma bond: 1
5. Chiwerengero cha ma tautomer: 24
6. Topological molecular polarity surface area 87
7. Chiwerengero cha maatomu olemera: 20
8. Malipiro apamwamba: 0
9. Kuvuta: 424
10. Chiwerengero cha maatomu a isotopic: 0
11. Dziwani kuchuluka kwa ma stereocenters a atomiki: 0
12. Chiwerengero cha ma stereocenters osatsimikizika a atomiki: 0
13. Dziwani kuchuluka kwa ma chemical bond stereocenters: 0
14. Chiwerengero cha ma indeterminate chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Pharmacological Action
Galangin imatha kusintha Salmonella typhimurium TA98 ndi TA100 ndipo imakhala ndi antiviral effect.
Mu Vitro Study
Galangin adaletsa catabolism ya DMBA m'njira yodalira mlingo.Galangin adaletsanso mapangidwe a DMBA-DNA adducts ndikulepheretsa DMBA kulepheretsa kukula kwa maselo.M'maselo osasunthika ndi ma microsomes otalikirana ndi ma cell omwe amathandizidwa ndi DMBA, galangin idapanga kuletsa kodalira kwa mlingo kwa CYP1A1 ntchito yoyesedwa ndi ntchito ya ethoxypurine-o-deacetylase.Kuwunika kwa inhibition kinetics ndi chithunzi chobwerezabwereza kunawonetsa kuti galangin inaletsa ntchito ya CYP1A1 m'njira yopanda mpikisano.Galangin imatsogolera kuwonjezeka kwa msinkhu wa CYP1A1 mRNA, kusonyeza kuti ikhoza kukhala agonist ya cholandilira chonunkhira cha hydrocarbon, koma imalepheretsa CYP1A1 mRNA (TCDD) yopangidwa ndi DMBA kapena 2,3,5,7-tetrachlorodibenzo-p-dioxin.Galangin imalepheretsanso kulembedwa kwa DMBA kapena TCDD kwa ma vector atolankhani okhala ndi CYP1A1 wolimbikitsa [1].Kuchiza kwa Galangin kunaletsa kuchuluka kwa ma cell komanso kuyambitsa autophagy (130) μ M) Ndipo apoptosis (370 μ M). 3, ndi (3) kuchuluka kwa ma cell okhala ndi ma vacuoles.Mawu a P53 adawonjezekanso. [2].
Kuyesera kwa Ma cell
Maselo (5.0 × 103) inoculated ndi mankhwala ndi woipa wosiyana wa galangin mu 96 bwino mbale kwa nthawi zosiyanasiyana.Powonjezera 10 μ L ya 5 mg / ml MTT yankho kuti mudziwe kuchuluka kwa maselo amoyo pachitsime chilichonse.Pambuyo pa makulitsidwe pa 37 ℃ kwa maola 4, maselowo adasungunuka mu 100% yankho lomwe lili ndi 20% SDS ndi 50% dimethylformamide μ L yankho.Kuchuluka kwa kuwala kunayesedwa pogwiritsa ntchito varioskan flash reader spectrophotometer pamayeso a kutalika kwa 570 nm ndi kutalika kwa mawonekedwe a 630 nm.
