Zogulitsa

Kufotokozera:glucoridin ndi isoflavane yochokera ku glycorrhiza glabra, yomwe imatha kumanga ndi kuyambitsa PPAR γ, Mtengo wa EC50 ndi 6115 nm.Glabridin ali ndi antioxidant, antibacterial, anti glomerulonephritis, anti-diabetes, anti-chotupa, anti-yotupa, anti osteoporosis, amateteza mtima, amateteza mitsempha, amawononga ma radicals aulere ndi ntchito zina.

Magulu ofananira:kafukufuku > > khansa
Njira yolumikizira>> kuzungulira kwa ma cell / kuwonongeka kwa DNA>> PPAR
Kafukufuku>> kutupa / chitetezo chokwanira

Phunziro la In Vitro:glabridin amamanga ndi yambitsa PPAR γ, EC50 ndi 6115 nm [1].Glabridin (40,80 μ M) Kuchulukitsitsa kwa ma cell a SCC-9 ndi SAS kunaletsedwa mulingo komanso nthawi yotengera nthawi pambuyo pa 24 ndi 48 maola a chithandizo [2].Glabridin (0-80 μ M) Imapangitsanso apoptosis, zomwe zimapangitsa kuti ma cell a G1 amangidwe mu SCC-9 ndi ma cell a SAS [2].Glabridin (0,20,40 ndi 80 μ M) Mlingo modalira adamulowetsa Caspase-3, - 8 ndi - 9 ndi kuchuluka PARP cleavage, kwambiri phosphorylating ERK1 / 2, JNK1 / 2 ndi P-38 MAPK mu SCC-9.Maselo [2].

Mu Phunziro la Vivo:glabridin (50 mg / kg, Po kamodzi patsiku) adawonetsa ntchito yolimbana ndi kutupa ndikuwongolera kusintha kwa kutupa komwe kumachitika ndi dextran sodium sulfate (DSS) [3]

Zolozera:[1] Rebhun JF, et al.Kuzindikiritsa glabridin ngati bioactive compound mu licorice (Glycyrrhiza glabra L.) yotulutsa yomwe imatsegula munthu peroxisome proliferator-activated receptor gamma (PPAR γ).Fitoterapia.Oct 2015;106:55-61 .
[2].Chen CT, et al.Glabridin imapangitsa apoptosis ndi kumangidwa kwa cell m'maselo a khansa ya m'kamwa kudzera mu njira yowonetsera ya JNK1 / 2.Environ Toxicol.2018 Jun;33(6):679-685.
[3].El-Ashmawy NE, et al.Kutsika kwa iNOS ndi kukwera kwa cAMP kumayimira anti-inflammatory effect ya glabridin mu makoswe omwe ali ndi ulcerative colitis.Inflammopharmacology.2018 Apr;26(2):551-559.