Hyperoside;Hypercin Cas No. 482-36-0
Zambiri Zokhudza Mankhwala
[dzina la mankhwala] hypericin
[Dzina la Chingerezi] Hyperoside
[zina] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[chilinganizo cha maselo] c21h20o12
[kulemera kwa maselo] 464.3763
[C monga Na.] 482-36-0
[Chemical classification] flavonoids
[gwero] Hypericum perforatum L
[Maganizo] > 98%
[Mawu achitetezo] 1. Osapumira fumbi.2.Pakachitika ngozi kapena kusapeza bwino, funani chithandizo chamankhwala mwachangu (onetsani chizindikiro chake ngati nkotheka).
[Pharmacological efficacy] Hypericin imafalitsidwa kwambiri.Ndi chinthu chofunika kwambiri chachilengedwe chokhala ndi zochitika zosiyanasiyana za thupi, monga anti-inflammatory, antispasmodic, diuretic, kuchepetsa chifuwa, kuchepetsa kuthamanga kwa magazi, kutsika kwa mafuta m'thupi, kutsekemera kwa mapuloteni, kupweteka kwapakati ndi pakati, ndi zoteteza pamtima ndi mitsempha ya ubongo.
[Mawonekedwe akuthupi ndi mankhwala] Mwala wachikasu acicular crystal.Malo osungunuka ndi 227 ~ 229 ℃, ndipo mawonekedwe a kuwala ndi - 83 ° (C = 0.2, pyridine).Imasungunuka mosavuta mu ethanol, methanol, acetone ndi pyridine ndipo imakhala yokhazikika pansi pazikhalidwe.Imachita ndi hydrochloric acid magnesium powder kuti ipange chitumbuwa chofiira, ndipo ferric chloride imachita zobiriwira, α-Naphthol reaction inali yabwino.
[Mawu owopsa] Zowopsa ngati zitamezedwa.
Pharmacological Action
1. Hypericin imakhala ndi mphamvu yochepetsera ululu, yomwe ndi yofooka kuposa morphine, yamphamvu kuposa aspirin, ndipo ilibe kudalira.Hypericin ndi mtundu watsopano wa analgesic wamba.
2. Hypericin ali ndi zabwino zoteteza kwambiri m`mnyewa wamtima ischemia-reperfusion, ubongo ischemia-reperfusion ndi ubongo infarction.
3. Hypericin ali ndi zodziwikiratu odana ndi yotupa zotsatira: pambuyo implantation wa ubweya mpira, makoswe intraperitoneally jekeseni ndi 20mg/kg tsiku lililonse kwa masiku 7, amene analetsa kwambiri yotupa ndondomeko.
4. Imakhala ndi antitussive effect.
5. Kutengera.
6. Kuletsa mwamphamvu kwa aldose reductase kungakhale kopindulitsa kuteteza matenda a shuga.
Chitetezo pa myocardial ischemia
Hypericin ikhoza kuchepetsa kuchuluka kwa apoptosis ya cardiomyocytes chifukwa cha hypoxia reoxygenation, kuletsa kutuluka kwa lactate dehydrogenase, kupititsa patsogolo ntchito ya myocardial superoxide dismutase (SOD) mu makoswe omwe ali ndi vuto la myocardial ischemia-reperfusion, kuchepetsa kupanga malondialdehyde (MDA), kuletsa kuwonjezeka kwa myocardial phosphokinase (CPK) mu seramu, komanso kuchepetsa mapangidwe a oxygen free radical and nitric oxide free radical, Pofuna kuteteza myocardium ndi kuchepetsa kuvulala kwa cardiomyocyte ndi cardiomyocyte apoptosis chifukwa cha ischemia-reperfusion.
Kuteteza mphamvu pa ubongo ischemia
Hypericin imatha kuletsa kuchepa kwa zinthu za formazan mu magawo aubongo pambuyo pa kuvulala kwa hypoxia glucose kulandidwa reperfusion, kuonjezera kuchuluka kwa ma neuron omwe amakhala mu kotekisi ndi striatum ya magawo aubongo m'dera la ischemic, ndikupanga morphology ya neuroni kukhala yokwanira ndikugawidwa bwino.Letsani kuchepa kwa ntchito za neuronal zoyambitsidwa ndi hypoxia glucose deprivation reperfusion kuvulala.Letsani kuchepa kwa ntchito za SOD, LDH ndi glutathione peroxidase (GSHPx).Kachitidwe kake kangakhale kokhudzana ndi kuwononga kwakukulu kwaufulu, kulepheretsa kuchuluka kwa Ca2 komanso mapangidwe a anti lipid peroxide.
Chitetezo pa chiwindi ndi chapamimba mucosa
Hypericin ali ndi zodziwikiratu zoteteza zimakhudza chiwindi minofu ndi chapamimba mucosa.Kachitidwe kake kamagwirizana ndi antioxidant effect, kulimbikitsa kubwerera kwa mlingo wa N0 kukhala wabwinobwino ndikuwonjezera ntchito za SOD.
Antispasmodic analgesic kwenikweni
Kafukufukuyu adapeza kuti mphamvu ya analgesic ya hypericin imapangidwa ndi kuchepetsa Ca 2 mu mathero opweteka a mitsempha.Nthawi yomweyo, hypericin imatha kulepheretsa kuchuluka kwa Ca 2 komwe kumabwera chifukwa cha potaziyamu wambiri, kusonyeza kuti hypericin imalepheretsanso njira ya Ca mumitsempha.Amanenedwanso kuti hypericin ikhoza kukhala chotchinga cha Ca 2 channel.Kuwunika kwachipatala kukuwonetsa kuti jakisoni wa hypericin ndi wofanana ndi atropine pochiza matenda a dysmenorrhea.Kupatula zovuta zina zowodzera, sizikhala ndi zotsatira zoyipa monga tachycardia, mydriasis ndi kutentha.Ndi yabwino antispasmodic ndi analgesic.
Zotsatira za Hypolipidemic
Hypericin imatha kuchepetsa kwambiri seramu ya TC ndikuwonjezera kuchuluka kwa HDL / TC mu mbewa zokhala ndi mafuta ambiri, zomwe zikuwonetsa kuti hypericin imatha kuchepetsa cholesterol, kuwongolera lipids m'magazi, ndikuwongolera magwiridwe antchito a HDL ndi seramu SOD mu mbewa.Izi zimatha kuchepetsa kwambiri kuwonongeka kwa superoxide yaulere ku endothelium yamtima mu hyperlipidemia, ndipo imathandizira kuwonongeka ndi kagayidwe ka lipid peroxide kuteteza mitsempha ya endothelium.
Limbikitsani chitetezo cha mthupi
Hypericin pa Mlingo wa 300 mg/kg ndi 150 mg/kg mu vivo akhoza kwambiri ziletsa thymus index, kuchuluka kwa ndulu T ndi B lymphocytes ndi phagocytosis wa peritoneal macrophages;Pa 59 mg / kg, idakulitsa kwambiri kuchuluka kwa ndulu T ndi B lymphocytes ndi phagocytosis ya peritoneal macrophages.Hypericin pa mlingo wa 50 ~ 6.25 ml mu m`galasi akhoza kwambiri kulimbikitsa kuchuluka kwa ndulu T ndi B lymphocytes ndi kumapangitsanso luso la T lymphocytes kubala IL-2;Hypericin pa 6,25 g/ml kwambiri anawonjezera luso mbewa peritoneal macrophages kuti phagocytize neutrophils, kuyambira 12.5 kuti 3.12 μ G / ml kwambiri kuchuluka luso mbewa peritoneal macrophages kumasula No.
Antidepressant zotsatira
Hypothalamic pituitary adrenal (HPA) activation ndikusintha kofala kwachilengedwe kwa odwala omwe ali ndi kupsinjika kwakukulu, komwe kumadziwika ndi kutulutsa kwakukulu kwa adrenocorticotropic hormone (ACTH) ndi cortisol.Hypericin imatha kuyendetsa ntchito ya HPA axis ndikuchepetsa milingo ya ACTH ndi corticosterone, kuti ikhale ndi gawo loletsa kupsinjika.
Anamaliza Mankhwala
Ciwujia capsule
Acanthopanax senticosus capsule ndi kukonzekera ndi Acanthopanax senticosus tsinde ndi masamba Tingafinye monga zopangira.Chigawo chachikulu ndi flavonoids, momwe hypericin ndi gawo lalikulu la masamba a Acanthopanax senticosus.
Zisonyezo zazikulu: kulimbikitsa kufalikira kwa magazi ndikuchotsa ma stasis.Amagwiritsidwa ntchito pachifuwa arthralgia ndi matenda amtima omwe amayamba chifukwa cha kukhazikika kwa magazi.Zizindikiro zake ndi monga kupweteka pachifuwa, kuthina pachifuwa, kugunda kwa mtima, kuthamanga kwa magazi, ndi zina zambiri. Ndi chifukwa cha kuchepa kwa ndulu ndi impso ndi magazi ndi Yin.
Xinan capsule
Ndiko kukonzekera kopangidwa ndi tsamba la hawthorn, lomwe lili ndi flavonoids, momwe hypericin ndi imodzi mwazinthu zazikulu.
Zisonyezo zazikulu: kukulitsa mitsempha yamagazi, kusintha magazi a myocardial ndikuchepetsa lipids.Amagwiritsidwa ntchito pochiza matenda a mtima, angina pectoris, chifuwa chachikulu, palpitations, matenda oopsa, etc.
Piritsi ya Qiyue Jiangzhi
Tabuleti ya Qiyue Jiangzhi ndi mankhwala achi China omwe amatsitsa lipid-kutsitsa lipids okonzedwa pochotsa mbali zogwira mtima zamankhwala achi China monga hawthorn (enucleated) ndi Astragalus membranaceus.Chimodzi mwazinthu zothandiza kwambiri za hawthorn ndi flavonoids, momwe hypericin zilili.
Zizindikiro zazikulu: kuchepetsa lipids m'magazi ndikufewetsa mitsempha yamagazi.Amagwiritsidwa ntchito kupititsa patsogolo kufalikira kwa magazi ndikuthana ndi arrhythmia ndi hyperlipidemia.
Xinxuening piritsi
Piritsi ya Xinxuening ndi mankhwala opangidwa ndi mankhwala achi China monga hawthorn ndi pueraria.Hawthorn ndiye mankhwala ovomerezeka a phwando lathu.Lili ndi ursolic acid, Vitexin rhamnoside, hypericin, citric acid, ndi zina zotero, zomwe hypericin ndi gawo lalikulu.
Zizindikiro zazikulu: kulimbikitsa kuyenda kwa magazi ndikuchotsa kukhazikika kwa magazi, kutsekereza zomangira ndikuchepetsa ululu.Amagwiritsidwa ntchito pachifuwa cha arthralgia ndi vertigo chifukwa cha kukhazikika kwa magazi ndi kukhazikika kwaubongo, komanso matenda amtima, matenda oopsa, angina pectoris ndi hyperlipidemia.
Yukexin kapisozi
Kapisozi wa Yukexin ndi mankhwala achi China omwe amapangidwa kuchokera kumankhwala akale, omwe amapangidwa ndi Hypericum perforatum, kernel ya jujube, khungwa la Albizzia, Gladiolus ndi mankhwala ena achi China.Makamaka muli hypericin, quercetin, quercetin, asidi chlorogenic, asidi caffeic, yimaning, hypericin ndi zigawo zina.
Zizindikiro zazikulu: kupsinjika kwamaganizidwe komwe kumachitika chifukwa cha kusakhazikika kwa chiwindi cha Qi komanso kusakhazikika bwino.
