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Zogulitsa

Methylophiopogonanone A;Opogonanone A

Kufotokozera Kwachidule:

Dzina Lodziwika: Ophiopogon japonicus high isoflavone a

Chichewa Dzina: methylophiopogonnone a

Nambala ya CAS: 74805-92-8

Kulemera kwa Molecular: 342.343

Kachulukidwe: 1.4 ± 0.1 g / cm3

Malo Owira: 580.1 ± 50.0 ° C pa 760 mmHg

Fomula ya mamolekyu: c19h18o6

Malo osungunuka: N/ A

MSDS: N/A

Flash Point: 212.9 ± 23.6 ° C


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kugwiritsa ntchito Methylophiopogonanone A

Methylophiopogonanone A ndi flavonoid yotengedwa ku Ophiopogon japonicas, yomwe ili ndi antioxidant ndi anti-inflammatory effect.

Dzina la Methylophiopogonanone A

Dzina la Chingerezi:
(3R) -3-(1,3-benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-imodzi

Dzina lachi China:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a

Ntchito Zachilengedwe Za Methylophiopogonanone A

Description: methylophiopogonanone A ndi flavonoid yotengedwa ku Ophiopogon japonicas,
antioxidant ndi anti-yotupa zotsatira.
Magulu Ofananira: njira yolumikizira>> apoptosis>> apoptosis
kafukufuku>> kutupa / chitetezo chokwanira

Phunziro mu Vitro: methyl aspartate a (mo-a; 10 μ Mo (L / L) idachepetsa kwambiri apoptosis ndi mawu a Caspase-3, kuchuluka kwa Bcl-2 / Bax ndikubwezeretsa kosapanga. Methylaspartate a (mo-a)

kumathandizira kwambiri kutsegulira kwa njira ya PI3K / Akt / eNOS m'maselo a H9c2 pansi pa H / R, pomwe chitetezo cha mo-a chinathetsedwa pamaso pa PI3K inhibitor wortmannin (100 nmol / L) [1].

Phunziro la Vivo: chitetezo cha methylaspartate a (mo-a; 10mg / kg / D, PO) pakugwira ntchito kwamtima pambuyo pa kuvulala kwa myocardial I / R [1].

Maumboni: [1] He F, et al.Methylophiopogonanone A amapondereza ischemia/reperfusion-induced myocardial apoptosis mu mbewa kudzera poyambitsa PI3K/Akt/eNOS njira yolumikizira.Acta Pharmacol Sin.2016 Jun;37(6):763-71.

Physicochemical katundu wa Methylophiopogonanone A

Kachulukidwe: 1.4 ± 0.1 g / cm3

Malo Owira: 580.1 ± 50.0 ° C pa 760 mmHg

Fomula ya mamolekyu: c19h18o6

Kulemera kwa Molecular: 342.343

Flash Point: 212.9 ± 23.6 ° C

Misa Yeniyeni: 342.110352

PSA: 85.22000

Chizindikiro: 5.16

Kuthamanga kwa Steam: 0.0 ± 1.7 mmHg pa 25 ° C

1.654

English Alias ​​Of Methylophiopogonanone A

(1,3-Benzodioxol-5-ylmethyl) -5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-imodzi

4H-1-Benzopyran-4-imodzi, 3-(1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-

N1002

Methylophiopogonanone A

Yongjian Service

Utumiki Wosinthidwa Wa Chemical Reference Zipangizo Zamankhwala Achikhalidwe Chachi China
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ikuchita nawo kafukufuku woyambira wamankhwala achikhalidwe achi China kwazaka zopitilira khumi.Pakadali pano, kampaniyo yachita kafukufuku wozama pamitundu yopitilira 100 yamankhwala achi China omwe amagwiritsidwa ntchito kwambiri, ndipo yatulutsa masauzande azinthu zamankhwala.

Kampaniyo ili ndi antchito apamwamba a R & D komanso zida zoyezera bwino komanso zowunikira pamsika, ndipo yatumikira mazana a mabungwe ofufuza asayansi.Ikhoza mwamsanga komanso moyenera kukwaniritsa zosowa za makasitomala

Kulekanitsa Zodetsa Zamankhwala, Kukonzekera ndi Kutsimikiza Kwamapangidwe
Zowonongeka mu mankhwala zimagwirizana kwambiri ndi khalidwe, chitetezo ndi kukhazikika kwa mankhwala.Kukonzekera ndi kutsimikizira kwapangidwe kwa zonyansa mu mankhwala kungatithandize kumvetsetsa njira zonyansa ndikupereka maziko opititsa patsogolo kupanga.Choncho, kukonzekera ndi kulekanitsa zonyansa ndizofunika kwambiri pa kafukufuku wa mankhwala ndi chitukuko.

Komabe, zonyansa zomwe zili mu mankhwalawa ndizochepa, gwero lake ndi lalikulu, ndipo kapangidwe kake kamakhala kofanana ndi gawo lalikulu.Ndi teknoloji iti yomwe ingagwiritsidwe ntchito kulekanitsa ndi kuyeretsa zonyansa zonse mu mankhwala amodzi ndi mofulumira?Ndi njira ndi njira ziti zomwe zimagwiritsidwa ntchito kutsimikizira mawonekedwe a zonyansazi?Izi ndizovuta komanso zovuta zomwe magulu ambiri azamankhwala amakumana nawo, makamaka mabizinesi azamankhwala amankhwala azitsamba ndi mankhwala ovomerezeka aku China.

Kutengera zosowa zotere, kampaniyo yakhazikitsa ntchito zolekanitsa zonyansa ndi zoyeretsa.Kudalira nyukiliya maginito resonance, misa spectrometry ndi zipangizo zina ndi matekinoloje, kampani mwamsanga kuzindikira dongosolo la olekanitsidwa mankhwala, kuti akwaniritse zosowa za makasitomala.

Kuyesa Kwanyama kwa SPF
Malo omangirako malo oyesera nyama ndi 1500 masikweya mita, kuphatikiza masikweya mita 400 a malo oyesera a SPF ndi 100 masikweya mita a labotale yama cell a P2.Motsogozedwa ndi asayansi aku China Pharmaceutical University, imapanga gulu lalikulu laukadaulo lomwe lili ndi anthu angapo obwerera.Perekani zitsanzo za zinyama zapamwamba kwambiri, mapangidwe oyesera, ntchito zonse ndi ntchito zina za kafukufuku wa sayansi ya zamankhwala, kuphunzitsa ndi chitukuko cha mafakitale.

Kuchuluka Kwa Bizinesi

1. Kudyetsa ziweto zazing'ono

2. Chitsanzo cha matenda a nyama

3. Kupititsa patsogolo ntchito zaku koleji

4. Pharmacodynamic evaluation mu vivo

5. Pharmacokinetic kuyesa

6. Ntchito yoyesera maselo a chotupa

Mphamvu Zathu

1. Yang'anani pa zoyeserera zenizeni

2. Mosakhazikika standardize ndondomeko

3. Sayiniratu mgwirizano wachinsinsi

4. Ma labotale omwe alibe maulalo apakatikati

5. Gulu laukadaulo la akatswiri limatsimikizira mtundu woyeserera

Malo oyesera a SPF, kudyetsa kwapadera kwa munthu, kutsatira nthawi yeniyeni yoyeserera


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