Zogulitsa

Naringin ndi aglycone ya naringin ndipo ndi ya dihydroflavonoids.Lili ndi ntchito za antibacterial, anti-inflammatory, free radical scavenging, antioxidant, chifuwa ndi expectorant, magazi lipid kutsitsa, odana ndi khansa, odana ndi chotupa, antispasmodic ndi cholagogic, kupewa ndi kuchiza matenda a chiwindi, chopinga kupatsidwa magazi coagulation, anti atherosulinosis ndi zina zotero.Itha kugwiritsidwa ntchito kwambiri muzamankhwala, chakudya ndi zina.

Antibacterial
Iwo ali amphamvu antibacterial zotsatira pa Staphylococcus aureus, Escherichia coli, kamwazi ndi typhoid bacillus.Naringin imakhudzanso bowa.Kupopera 1000ppm pa mpunga kungachepetse matenda a Magnaporthe grisea ndi 40-90%, ndipo alibe poizoni kwa anthu ndi ziweto.

Antiinflammatory
Makoswe amabayidwa intraperitoneally ndi 20mg / kg tsiku lililonse, zomwe zimalepheretsa kwambiri kutupa komwe kumayambitsidwa ndi kuyika kwa mpira wa ubweya.Galatiya et al.Anapeza kuti gulu lililonse la mlingo wa naringin linali ndi anti-inflammatory effect kupyolera mu kuyesa kwa piritsi la khutu la mbewa, ndipo zotsatira zotsutsa-zotupa zinawonjezeka ndi kuwonjezeka kwa mlingo.Kuletsa kwa gulu la mlingo waukulu kunali 30.67% ndi kusiyana kwa makulidwe ndi 38% ndi kusiyana kwa kulemera.[4] Feng Baomin et al.Anachititsa gawo 3 dermatitis mu mbewa ndi DNFB njira, ndiyeno anapereka naringin pakamwa kwa 2 ~ 8 masiku kuona chopinga mlingo wa nthawi yomweyo gawo (IPR), mochedwa gawo (LPR) ndi ultra late phase (VLPR).Naringin imatha kuletsa edema ya khutu ya IPR ndi VLPR, ndipo imakhala ndi phindu linalake lodana ndi kutupa.

Kuwongolera chitetezo cha mthupi
Naringin amasunga kusinthasintha koyenera kwa kuthamanga kwa okosijeni mu nthawi yeniyeni ndi zigawo zenizeni poyendetsa kayendedwe ka ma electron mu mitochondria.Choncho, ntchito ya immunomodulatory ya naringin ndi yosiyana ndi yachikhalidwe yosavuta yowonjezera chitetezo cha mthupi kapena ma immunosuppressants.Makhalidwe ake ndikuti amatha kubwezeretsa chitetezo chamthupi chosagwirizana (pathological state) kuti akhale pafupi ndi chitetezo chamthupi (thupi), M'malo mongowonjezera kapena kuletsa kuyankha kwa chitetezo chamthupi.

Malamulo a msambo kwa akazi
Naringin ali ndi ntchito yofanana ndi mankhwala osagwiritsa ntchito steroidal odana ndi kutupa.Ikhoza kuchepetsa kaphatikizidwe ka prostaglandin PGE2 mwa kuletsa cyclooxygenase Cox, ndikugwira ntchito ya antipyretic, analgesic ndi kuchepetsa kutupa.
Kutengera ndi estrogen ngati zotsatira za naringin, naringin angagwiritsidwe ntchito pochiza estrogen m'malo mwa amayi omwe ali ndimenopausal kupewa zovuta zoyipa zomwe zimachitika chifukwa chogwiritsa ntchito estrogen kwa nthawi yayitali.

Zotsatira za kunenepa kwambiri
Naringin ali ndi chithandizo chodziwikiratu pa hyperlipidemia ndi kunenepa kwambiri.
Naringin imatha kusintha kwambiri kuchuluka kwa cholesterol m'madzi a m'magazi, TG (triglyceride) komanso kuchuluka kwamafuta amafuta aulere mu makoswe onenepa.Zinapezeka kuti naringin imatha kuwongolera monocyte peroxisome proliferator activated receptor mu makoswe amtundu wamafuta δ, Kuchepetsa kuchuluka kwa lipid m'magazi.
Kudzera m'mayesero azachipatala, zidapezeka kuti odwala omwe ali ndi hypercholesterolemia adatenga kapisozi imodzi yokhala ndi 400mg naringin tsiku lililonse kwa milungu isanu ndi itatu.Miyezo ya TC ndi LDL cholesterol m'madzi a m'magazi idatsika, koma kuchuluka kwa cholesterol ya TG ndi HDL sikunasinthe kwambiri.
Pomaliza, naringin imatha kusintha hyperlipidemia, yomwe yatsimikiziridwa bwino muzoyesa za nyama ndi mayesero azachipatala.

Kuchotsa ma free radicals ndi antioxidation
DPPH (dibenzo bitter acyl radical) ndi stable free radical.Kutha kwake kuwononga ma radicals aulere kumatha kuwunikidwa ndi 517 nm absorbance attenuation.[6] Kroyer adaphunzira za antioxidant zotsatira za naringin kudzera muzoyesera ndipo adatsimikizira kuti naringin ili ndi antioxidant effect.[7] Zhang Haide et al.Kuyesa njira ya lipid peroxidation ya LDL ndi colorimetry komanso kuthekera koletsa kusintha kwa okosijeni kwa LDL.Naringin makamaka chelates Cu2 + kudzera m'magulu ake a 3-hydroxyl ndi 4-carbonyl, kapena amapereka proton ndi free radical neutralization, kapena amateteza LDL ku lipid peroxidation kudzera pamadzi oxidation.Zhang Haide ndi ena adapeza kuti naringin ili ndi zotsatira zabwino zaufulu zowononga ndi njira ya DPPH.The ufulu kwakukulu mkangaziwisi zotsatira akhoza anazindikira ndi hydrogen makutidwe ndi okosijeni wa naringin palokha.[8] Peng Shuhui et al.Ntchito experimental chitsanzo cha kuwala riboflavin (IR) - nitrotetrazolium kolorayidi (NBT) - spectrophotometry kutsimikizira kuti naringin ndi zoonekeratu mkangaziwisi zotsatira pa zotakasika mpweya mitundu O2 - amene ali wamphamvu kuposa ascorbic asidi mu ulamuliro zabwino.Zotsatira za kuyesa kwa nyama zinawonetsa kuti naringin inali ndi mphamvu yolepheretsa lipid peroxidation mu ubongo wa mbewa, mtima ndi chiwindi, ndipo imatha kupititsa patsogolo ntchito ya superoxide dismutase (SOD) m'magazi a mbewa.

Chitetezo cha Mtima
Naringin ndi naringin zimatha kuwonjezera zochita za acetaldehyde reductase (ADH) ndi acetaldehyde dehydrogenase (ALDH), kuchepetsa zomwe zili mu triglycerides m'chiwindi ndi cholesterol yonse m'magazi ndi chiwindi, kuonjezera zomwe zili mu high density lipoprotein cholesterol (HDLC), kuonjezera chiŵerengero. wa HDLC ku cholesterol chonse, ndikuchepetsa index ya atherogenic panthawi imodzimodzi, Naringin imatha kulimbikitsa kunyamula mafuta m'thupi kuchokera ku plasma kupita ku chiwindi, kutulutsa kwa bile ndi kutulutsa, ndikuletsa kusintha kwa HDL kupita ku VLDL kapena LDL.Choncho, naringin ingachepetse chiopsezo cha arteriosclerosis ndi matenda a mtima.Naringin imatha kuchepetsa kuchuluka kwa cholesterol mu plasma ndikulimbitsa kagayidwe kake.

Zotsatira za Hypolipidemic
Zhang Haide et al.Kuyesedwa kwa serum cholesterol (TC), low density lipoprotein cholesterol (LDL-C), plasma high density lipoprotein cholesterol (HDL-C), triglyceride (TG) ndi zinthu zina za mbewa pambuyo pa kulowetsedwa m'mitsempha kudzera muzoyeserera zanyamaZotsatira zidawonetsa kuti naringin imatha kuchepetsa kwambiri. seramu TC, TG ndi LDL-C ndikuwonjezera seramu HDL-C pa mlingo wina, kusonyeza kuti naringin inali ndi zotsatira zochepetsera lipid ya magazi mu mbewa.[

Ntchito ya Antitumor
Naringin imatha kuwongolera chitetezo chamthupi ndikuletsa kukula kwa chotupa.Naringin ali ndi zochita pa makoswe khansa ya m'magazi L1210 ndi sarcoma.Zotsatira zake zidawonetsa kuti chiwopsezo cha mbewa / kulemera kwa thupi la mbewa chinawonjezeka pambuyo pakamwa pakamwa pa naringin, kuwonetsa kuti naringin imatha kupititsa patsogolo chitetezo chamthupi.Naringin imatha kuwongolera kuchuluka kwa ma T lymphocyte, kukonza kufooka kwa chitetezo chamthupi chifukwa cha chotupa kapena radiotherapy ndi chemotherapy, ndikuwonjezera kupha kwa maselo a khansa.Akuti naringin imatha kuonjezera kulemera kwa thymus mu mbewa zokhala ndi khansa ya ascites, kutanthauza kuti imatha kupititsa patsogolo chitetezo cha mthupi komanso kulimbikitsa mphamvu zake zamkati zotsutsana ndi khansa.Zinapezeka kuti pomelo peel Tingafinye anali inhibitory zotsatira pa S180 sarcoma, ndi chotupa chopinga mlingo anali 29.7%.

Antispasmodic ndi cholagogic
Lili ndi mphamvu kwambiri mu flavonoids.Naringin imakhudzanso kwambiri kutulutsa kwa bile mu nyama zoyesera.

Antitussive ndi Expectorant Effect
Pogwiritsa ntchito phenol wofiira monga chizindikiro cha zotsatira za kuthetsa matenda, kuyesera kumasonyeza kuti naringin ali ndi chifuwa champhamvu ndi expectorant kwenikweni.

Ntchito Yachipatala
Amagwiritsidwa ntchito pochiza matenda a bakiteriya, sedative ndi anticancer.
Fomu ya mlingo wa ntchito: suppository, mafuta odzola, jakisoni, piritsi, kapisozi, etc.