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OEM Manufacturer Arnicolide D - 3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin – Yongjian

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OEM Manufacturer Arnicolide D - 3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin – Yongjian Detail:

Application of Methylnissolin

Methylnisolin (astrapterocarpan) is isolated from Astragalus membranaceus and can inhibit cell proliferation induced by platelet-derived growth factor (PDGF) – BB, with an IC50 of 10 μ M。 Methylnisolin inhibits the phosphorylation of extracellular signal regulated kinase 1 / 2 (eric1 / 2) mitogen activated protein (map) kinase induced by PDGF-BB. Methylnisolin inhibits PDGF-BB induced proliferation of vascular smooth muscle cells by inhibiting ERK1 / 2 MAP kinase cascade.

Name Of Methylnissolin

English Name:

(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran

Chinese Alias: 3-hydroxy-9,10-dimethoxy red sandalwood | Astragalus red

sandalwood | (6aR, 11ar) – 3-hydroxy-9,10-dimethoxy red sandalwood

Biological Activity of Methylnissolin

Description: methylnisolin (astrapterocarpan) is isolated from Astragalus membranaceus

and can inhibit the cell proliferation induced by platelet-derived growth factor (PDGF) – BB.

The IC50 is 10 μ M。 Methylnisolin inhibits the phosphorylation of extracellular signal

regulated kinase 1 / 2 (eric1 / 2) mitogen activated protein (map) kinase induced by

PDGF-BB. Methylnisolin inhibits PDGF-BB induced proliferation of vascular smooth

muscle cells by inhibiting ERK1 / 2 MAP kinase cascade.

Related Categories: research field > > cardiovascular disease

signal pathway > > protein tyrosine kinase > > PDGFR

signal path > > MAPK / ERK signal path > > ERK

signaling pathway > > stem cells and Wnt pathway > > ERK

Traget:PDGFR:10 μM (IC50)

ERK1

ERK2

Reference:[1]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7.

Physicochemical properties of Methylnissolin

Density: 1.3 ± 0.1 g / cm3

Boiling Point: 428.9 ± 45.0 ° C at 760 mmHg

Molecular Formula: c17h16o5

Molecular Weight: 300.306

Flash Point: 213.2 ± 28.7 ° C

Accurate Mass: 300.099762

PSA:57.15000

LogP:2.45

Steam Pressure: 0.0 ± 1.1 mmHg at 25 ° C

Refractive Index: 1.612

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., established in March 2012, is a high-tech enterprise integrating R & D, production and sales. It is mainly engaged in the production, customization and production process development of active components of natural products, traditional Chinese medicine reference materials and drug impurities. The company is located in China Pharmaceutical City, Taizhou City, Jiangsu Province, including a 5000 square meter production base and a 2000 square meter R & D base. It mainly serves major scientific research institutes, universities and decoction piece production enterprises across the country.

So far, we have developed more than 1500 kinds of natural compound reagents, and compared and calibrated more than 300 kinds of reference materials, which can fully meet the daily inspection needs of major scientific research institutes, university laboratories and decoction pieces production enterprises.

Based on the principle of good faith, the company hopes to sincerely cooperate with our customers. Our aim is to serve the modernization of traditional Chinese medicine.

Advantageous Business Scope Of The company

1. R & D, production and sales of chemical reference materials of traditional Chinese medicine;

2. Customized traditional Chinese medicine monomer compounds according to customer characteristics

3. Research on quality standard and process development of traditional Chinese medicine (plant) extract

4. Technology cooperation, transfer and new drug research and development.


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OEM Manufacturer Arnicolide D - 3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin –  Yongjian detail pictures


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With our excellent management, strong technical capability and strict quality control system, we continue to provide our clients with reliable quality, reasonable prices and excellent services. We aim at becoming one of your most reliable partners and earning your satisfaction for OEM Manufacturer Arnicolide D - 3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin – Yongjian , The product will supply to all over the world, such as: Kuwait, Ottawa, Dominica, The products has a good reputation with competitive price, unique creation, leading the industry trends. The company insists on the principle of win-win idea, has establishedglobal sales network and after-sales service network.
  • This supplier offers high quality but low price products, it is really a nice manufacturer and business partner.
    5 Stars By Stephanie from Oman - 2017.03.08 14:45
    The company leader recept us warmly, through a meticulous and thorough discussion, we signed a purchase order. Hope to cooperate smoothly
    5 Stars By Lynn from Kuwait - 2017.02.28 14:19
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