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Essential Information

CAS No.: 524-30-1 [1]

EINECS No.: 208-355-5

Molecular Formula: c16h18o10

Molecular Weight: 370.3081

Molecular Structure: (Figure 1)

Properties: Light yellow acicular crystal or flake crystal.

Density: 1.634g/cm3

Boiling Point: 722.2 ° C at 760 mmHg

Flash Point: 267 ° C

Steam Pressure: 6.87e-22mmhg at 25 ° C

Bioactivity of Fraxin

Description: Fraxin can be isolated from Acer tegmentosum, F. ornus and a. hippocastanum. It is a glycoside of fraxine [1] and has antioxidant, anti-inflammatory and anti metastasis activities. Fraxin exhibits antioxidant activity by inhibiting cyclic adenylate phosphodiesterase [2].

Target: cyclo AMP phosphodiesterase enzyme [2]

In Vitro Study: Fraxin (100 μ M) It has no cytotoxicity to Hep G2 cells. Fraxin at non cytotoxic concentrations significantly reduced t-BHP induced ROS production in a dose-dependent manner [1]. Fraxin (0.5 mm) can scavenge free radicals at high concentration and has cytoprotective effect on H2O2 mediated oxidative stress [2].

In vivo study: Fraxin (50 mg / kg, PO) significantly blocked CCl4 induced elevation of ALT and AST. Fraxin (10 and 50 mg / kg, PO) significantly reduced GSSG levels (1.7 ± 0.3 and 1.5 ± 0.2 nm / g liver, respectively) compared with GSSG levels in the CCl4 treated group

Reference:. Fraxin (50 mg/kg, p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl4-treated group[1].

[2]. Whang WK, et al. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46.