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Application Of Esculin

Bioflavonoids, antioxidant, promote the content of vitamin C.

Action Of Esculin

1. Anti inflammation and analgesia: rats were injected intraperitoneally with 10mg / kg. Carrageenan induced, dextrose induced, serotonin induced and histamine induced “arthritis” had inhibitory effects, and the inhibitory intensities were 35,28,20,8% respectively It is also reported that it has inhibitory effect on formaldehyde induced arthritis, but the effect is weaker than that of carrageenan induced arthritis; The inhibition of dextran arthritis is not obvious It can inhibit the formation of granuloma in rats (cotton ball method), erythema reaction caused by ultraviolet radiation on the back of guinea pigs, and the increase of capillary permeability caused by histamine It has weak analgesic effect.

2. Effect on urine volume and uric acid excretion: various administration routes can enhance uric acid excretion in rats and rabbits, and have no diuretic effect on normal rats, but have significant diuretic effect on mice.

3.Others: antibacterial, anticoagulant and inhibiting aldose reductase in rat lens.

Name Of Esculin

English Name :esculin

Chinese Name:Heptachlor hemihydrate | heptachlor hemihydrate | 6-（ β- D-glucopyranoxy) – 7-hydroxy-2h-1-benzofuran-2-one | aescin | horse chestnut bark glycoside | chestnut bark glycoside Seven leaf spirit Aescin | Qiyeling | chestnut bark glycoside | aescin | 6 – (beta-d-glucopyranoxy) – 7-hydroxy-2h-1-benzofuran-2-one

Bioactivity of Esculin

Description: esculin is a fluorescent coumarin glucoside, which is an effective component of gray bark. Esculin improves cognitive impairment in experimental diabetic nephropathy (DN) through MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects.

Related Categories: research field > > cancer

Target: p38 MAPK

Reference:

[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct; 178(2):795-807.

[2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May; 17(5):7395-7402.

Physicochemical Properties of Esculin

Density: 1.7 ± 0.1 g / cm³

Boiling Point: 697.7 ± 55.0 ° C at 760 mmHg

Melting Point: 203 ° C

Molecular Formula: c15h16o9

Molecular Weight: 358.297

Flash Point: 262.8 ± 25.0 ° C

Exact mass: 358.089996

PSA:358.089996

LogP:-1.52

Appearance: cream powder

Steam Pressure: 0.0 ± 2.3 mmHg at 25 ° C

Refractive Index: 1.689

Storage Conditions

1 Store in a cool, dry and well ventilated warehouse. Keep away from kindling and heat sources. Protect from direct sunlight. Package sealing. It shall be stored separately from acids and edible chemicals, and mixed storage shall not be allowed. The storage area shall be equipped with appropriate materials to contain leakage.

2. Argon filled sealed storage

Stability: use and store according to the specifications without decomposition and avoid contact with oxides

Water Solubility: model soluble

Molecular Structure

1. Molar refractive index: 77.35

2. Molar volume (cm3 / mol): 202.6

3. Isotonic specific volume (90.2k): 628.5

4. Surface tension (dyne / cm): 92.6

5. Polarizability (10-24cm3): 30.66

Esculin Safety Information

Hazard code (Europe): F, C, Xi

Risk Statement (Europe): R11

Safety Statement (Europe): s26-s36 / 37 / 39-s45-s24 / 25

Transport Code of dangerous goods: UN 2924 3 / PG 2

Wgk Germany: 3

RTECS No.: dj3085000

Customs Code: 2942000000

Esculin Customs

Customs Code:2942000000

English Alias of Esculin

Crataegin

7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside

EINECS 208-517-5

vitaminc2

Enallachrome

Esculetin 6-β-D-glucoside

POLYDROM

Bicolorin

Esculetin 6-O-glucoside

Polychrom

7-Hydroxy-2-oxo-2H-chromen-6-yl-β-D-glucopyranoside

BICOLOIN

7-Hydroxycoumarin-6-yl β-D-Glucopyranoside Sesquihydrate

Esculin

7-Hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one

6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one

Esculetin 6-b-D-glucoside

2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-

7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1)

Aesculin

MFCD00006879

Esculetin-6-O-glucoside

2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1)

Escosyl