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Application of Ammonium Glycyrrhizinate

Monoammonium glycyrrhizinate hydrate has pharmacological activities such as anti-inflammatory, anti allergic, anti gastric ulcer and anti hepatitis.

Name Of Ammonium Glycyrrhizinate

Chinese Name:
Ammonium Glycyrrhizinate

English Name:
glycorrhizic acid ammonia salt

Chinese Alias:
glycyrrhizic acid monoammonium hydrate | glycyrrhizic acid monoammonium hydrate | glycyrrhizic acid monoammonium salt | glycyrrhizic acid monoammonium salt | glycyrrhizic acid monoammonium salt hydrate | glycyrrhizic acid monoammonia

Bioactivity Of Ammonium Glycyrrhizinate

Description: monoammonium glycyrrhizinate hydrate has pharmacological activities such as anti-inflammatory, anti allergic, anti gastric ulcer and anti hepatitis.

Related categories:
signal path > > other > > other
Research field > > inflammation / immunity

In Vivo Study: the increase of lung w / D weight ratio was significantly reduced by administration of high and medium doses of mag (10 and 30 mg / kg). Pretreatment with mag (10 and 30 mg / kg) effectively reduced TNF- α And IL-1 β Generation of. Mag (10,30 mg / kg) significantly reduced NF compared with LPS- κ Bp65 protein expression. In contrast, LPS significantly reduced I compared with the control group κ B- α Protein expression, while mag (10 and 30 mg / kg) significantly increased I κ B- α Expression [1]. Compared with RIF and INH groups, low-dose and high-dose MAG treatment significantly reduced ast, alt, TBIL and TBA levels at 14 and 21 days, indicating the protective effect of MAG on RIF – and INH -. Induce liver injury. MAG treatment group increased liver GSH level at 7, 14 and 21 days, and significantly decreased MDA level at 14 and 21 days in RIF and INH treated rats, indicating the protective effect of MAG in RIF – and. INH induced liver injury [2].

Animal Experiments: mice [1] in this study, BALB / c mice (male, 6-8 weeks old, 20-25g) were used. Mice were randomly divided into 5 groups: control group, LPS group and LPS + monoammonium glycyrrhizinate (Mag: 3,10 and 30mg / kg). Each group contained 8 mice. Mice were anesthetized with intraperitoneal injection of pentobarbital sodium (50 mg / kg). Mice were injected intraperitoneally with mag (3, 10 and 30 mg / kg) before inducing acute lung injury. After 1 hour, LPS (5 mg / kg) was injected intratracheal to induce acute lung injury. Normal mice were given PBS [1]. Rats [2] used male Wistar rats (180-220g). The rats were randomly divided into 4 groups: control group, RIF and INH group, MAG low-dose group and MAG high-dose group, with 15 rats in each group. Rats in RIF and INH groups were given RIF (60mg / kg) and INH (60mg / kg) by gavage once a day; Rats in MAG group were pretreated with MAG at the dose of 45 or 90 mg / kg, and RIF (60 mg / kg) and INH (60 mg / kg) were given 3 hours after MAG administration; The rats in the control group were treated with normal saline. In order to evaluate the dynamic effect of the drug, the rats in each group were killed 7, 14 and 21 days after administration [2].

Reference:1]. Huang X, et al. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:272474.
[2]. Zhou L, et al. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver. Pharm Biol. 2016;54(6):931-7.

Physicochemical Properties of Ammonium Glycyrrhizinate

Density: 1.43g/cm

Boiling point: 971.4 º C at 760mmhg

Melting Point: 209 º C

Molecular Formula: c42h65no16

Molecular Weight: 839.96

Flash Point: 288.1 º C

PSA:272.70000

LogP:0.32860

Appearance: white crystalline powder

Refractive Index: 49 ° (C = 1.5, EtOH)

Storage Conditions: sealed and stored at 2 º C – 8 º C

Stability: if used and stored according to specifications, it will not decompose and there is no known dangerous reaction

Water Solubility: slightly soluble in water, very slowly soluble in anhydrous ethanol, practically soluble in acetone It dissolves in dilute solutions of acids and of alkali hydroxides.

Ammonium Glycyrrhizinate MSDS

Ammonium Glycyrrhizinate MSDS

1.1 product identifier

Ammonium Glycyrrhizinate comes from licorice root (licorice)

Product name

1.2 other methods of identification

Glycyrrhizin

3-O-(2-O- β- D-Glucopyranuronosyl- α- D-glucopyranuronosyl)-18 β- glycyrrhetinic acidammonium salt

1.3 relevant identified uses of substances or mixtures and suggested unsuitable uses

Only for scientific research purposes, not as drugs, family standby drugs or other purposes。

Ammonium Glycyrrhizinate Safety Information

Personal protective equipment: eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter

Dangerous goods transport code: UN 3077 9 / pgiii

Wgk Germany: 2

RTECS No.: lz6500000

Preparation of Ammonium Glycyrrhizinate

It can be refined with acid ethanol as raw material.

Ammonium glycyrrhizinate literature

The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.

Int. J. Oncol. 46(2) , 667-76, (2014)

The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated…

TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA.

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1.

Int. Immunopharmacol. 26 , 112-8, (2015)

High mobility group box 1 (HMGB1) is now recognized as a late mediator of sepsis. Although glycyrrhizin was known as inhibitor of HMGB1, it is not yet clear underlying mechanism(s). We found that glyc…

English Alias Ammonium glycyrrhizinate

GLYCAMIL

Ammoniumglycynhizinato

glycyrrhizic acid monoammonium salt

ammonium glycyrrhizinate

MFCD00167400

Glycyrrhizin Monoammonium Salt Hydrate

Glycyrrhizic Acid Monoammonium Salt Hydrate

(3β)-30-Hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid diammoniate

GLYCYRRHIZICAMMONIUM

Magnasweet

ammoniate

Monoammonium Glycyrrhizinate Hydrate

Glycyrrhizate monoammonium