Panaxadiol Cas No. 19666-76-3
Biological Activity of Panaxadiol
Description: Panaxadiol is a novel antitumor drug isolated from ginseng.
Related categories: signal path > > other > > other
Research field > > cancer
Natural Products > > terpenoids and glycosides
Reference: [1]. Xiaojun C, et al. An UFLC-MS/MS method for quantification of panaxadiol in rat plasma and its application to a pharmacokinetic study. Planta Med. 2013 Sep;79(14):1324-8.
[2]. Tae-Hoon Kim, et al. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food and Chemical ToxicologyVolume 48, Issue 6, June 2010, Pages 1516–1520
Physicochemical Properties Of Panaxadiol
Density: 1.0 ± 0.1 g / cm3
Boiling Point: 531.3 ± 45.0 ° C at 760 mm
HgMolecular Formula: C30H52O3
Molecular Weight: 460.732
Flash Point: 275.1 ± 28.7 ° C
Accurate Mass: 460.391632
PSA: 49.69000
LogP: 7.64
Vapor Pressure: 0.0 ± 3.2 mmHg at 25 ° C
Refractive Index: 1.515
1. Character: uncertain
2. Density (g / ml, 25 / 4 ℃): uncertain
3. Relative vapor density (g / ml, air = 1): uncertain
4. Melting point (º C): 250
5. Boiling point (º C, atmospheric pressure): uncertain
6. Boiling point (º C, 5.2kpa): uncertain
7. Refractive index: uncertain
8. Flash point (º C): uncertain
9. Specific rotation (º): uncertain
10. Spontaneous combustion point or ignition temperature (º C): uncertain
11. Vapor pressure (kPa, 25 º C): uncertain
12. Saturated vapor pressure (kPa, 60 º C): uncertain
13. Heat of combustion (kJ / mol): uncertain
14. Critical temperature (º C): uncertain
15. Critical pressure (kPa): uncertain
16. Logarithm of oil-water (octanol / water) partition coefficient: uncertain
17. Upper explosion limit (%, V / V): uncertain
18. Lower explosive limit (%, V / V): uncertain
19. Solubility: uncertain
Preparation of Panaxadiol
The latest preparation method of ginseng extract is as follows: 100g of 5 ~ 6-year-old people are crushed and stirred into mud, 400ml of 90% ethanol is added, soaked and stirred for one day and night, filtered, and 300ml of 90% ethanol is added to the filter residue for the second extraction. Combine the two filtrates and evaporate the ethanol in the evaporator, leaving about 4G of concentrate. Add 150ml of 60% in the concentrate, stir to dissolve, filter and remove the insoluble matter. Concentrate the filtrate to 5-10ml, add 60ml of water, extract it with 80ml of ether for 3 times in the separating funnel, combine the ether layer, add 50ml of 6% sodium bicarbonate solution, shake fully, stand for layering, take the ether layer and wash it with distilled water to neutral. Then the ether is removed by evaporator until the ether is completely distilled, and the obtained ginseng extract.
English Alias Of Panaxadiol
PALMITIC ACID METHYLESTER(RG) (SEE METHYL PALMITATE)
(3β,12β,20R)-20,25-Epoxydammarane-3,12-diol
Panaxaidol
DAMMARANE-3BETA,12BETA-DIOL
Dammarane-3,12-diol, 20,25-epoxy-, (3β,12β,20R)-
Panaxadio
