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Popular Design for okanin - Isoliquiritin Apioside – Yongjian

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Popular Design for okanin - Isoliquiritin Apioside – Yongjian Detail:

Application of Isoliquiritin Apioside

Isoliquiritin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.

Name of Isoliquiritin Apioside

Chinese Name: Isoliquiritin Apioside

English Name: (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one

Bioactivity of Isoliquiritin Apioside

Description: isoliquitin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.

Related Categories: research field > > cancer
Signal path > > MAPK / ERK signal path > > p38 MAPK
Signaling pathway > > metabolic enzyme / protease > > MMP

Target:  MMP9
NF-κB
p38 MAPK

In vitro study: isorlicin could effectively inhibit the gelation MMP-9 activity of PMA induced HT1080 cells. Isoglycyrrhizin apigenin reduces the increase of MMP-9 production in HT1080 cells induced by PMA, has the ability of anti metastasis and anti angiogenesis in malignant tumor cells and endothelial cells, and has no cytotoxicity [1].

Reference:  [1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.

Physicochemical properties of Isoliquiritin Apioside

Density: 1.6 ± 0.1 g / cm3

Boiling point: 901.0 ± 65.0 ° C at 760 mmHg

Molecular formula: c26h30o13

Molecular weight: 550.509

Flash point: 301.9 ± 27.8 ° C

Accurate mass: 550.168640

PSA:215.83000

LogP:1.96

Steam pressure: 0.0 ± 0.3 mmHg at 25 ° C

Refractive index: 1.709

English alias of Isoliquiritin Apioside

2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-

3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside

Neolicuroside


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"Quality initial, Honesty as base, Sincere support and mutual profit" is our idea, so as to build repeatedly and pursue the excellence for Popular Design for okanin - Isoliquiritin Apioside – Yongjian , The product will supply to all over the world, such as: Slovakia, United Arab Emirates, Malawi, We are proud to supply our products and solutions to every costumer all around the world with our flexible, fast efficient services and strictest quality control standard which has always approved and praised by customers.
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