Astragaloside IV CAS No 84687-43-4
Intangiriro
Icyongereza Alias ：Astragaloside IV;beta-D-Glucopyranoside, (3beta, 6alpha, 16beta, 24R) -20,24-epoxy-16,25-dihydroxy-3- (beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta, 6alpha, 9beta, 16beta, 20R, 24S) -16,25-dihydroxy-3- -hexopyranoside
Inzira ya molekulari ：C41H68O14
Izina ryimiti:17- [5-. phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside
Mp:200 ~ 204 ℃
[α] D:-56,6 （c, 0.13 muri DMF）
UV:xmax203 nm
ubuziranenge ：98%
Inkomoko:ibinyamisogwe Astragalus membranaceus, Astragalus pubescens.
Imiterere yimiti ya astragaloside IV
Ibyiza bya fiziki
[isura]:ifu ya kirisiti yera
[ubuziranenge]:hejuru ya 98%, uburyo bwo gutahura: HPLC
[isoko y'ibimera]:imizi ya Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) umuzi wa Bungede, Astragalus sieversianus Pall Imizi ya Astragalus spinosus Vahl, igice cyo mu kirere cya Astragalus spinosus Vahl.
[ibicuruzwa]Astragalus membranaceus ikuramo ni ifu yumuhondo.
[kugena ibirimo]:kugena na HPLC (Umugereka wa VI D, Umubumbe wa I, Pharmacopoeia y'Ubushinwa, Edition 2010).
Imiterere ya Chromatografique hamwe nikizamini cya sisitemu ikoreshwa} octadecyl silane ihujwe na silika gel ikoreshwa nkuzuza, amazi ya acetonitrile (32:68) ikoreshwa nkicyiciro kigendanwa, naho icyuma kimena urumuri rukoreshwa mugushakisha.Umubare w'ibyapa byerekana ntabwo ugomba kuba munsi ya 4000 ukurikije impinga ya astragaloside ya IV.
Gutegura ibisubizo bifatika, fata urugero rukwiye rwa astragaloside ya IV, ubipime neza, hanyuma wongeremo methanol kugirango utegure igisubizo kirimo 0.5mg kuri 1ml.
Gutegura igisubizo cyibizamini:fata ifu ya 4G ivuye muri iki gicuruzwa, uyipime neza, uyishyire muri Soxhlet ikuramo, ongeramo 40ml ya methanol, uyishiremo ijoro ryose, ongeramo methanol ikwiye, ubushyuhe hamwe no kugaruka kumasaha 4, kugarura ibishishwa bivuyemo hanyuma ushire hamwe kuyumisha, ongeramo 10ml y'amazi kugirango ushonge ibisigisigi, kunyeganyega no kuyikuramo hamwe na n-butanol yuzuye inshuro 4, 40ml buri mwanya, uhuze n-butanol, hanyuma ukarabe byuzuye hamwe nigisubizo cya ammonia inshuro 2, 40ml buri umwe igihe, guta igisubizo cya ammonia, guhumeka igisubizo cya n-butanol, ongeramo 5ml amazi kugirango ushongeshe ibisigara, hanyuma ukonje, Binyuze muri D101 macroporous adsorption resin inkingi (diameter y'imbere: 37.5px, uburebure bwinkingi: 300px), kuramba hamwe na 50ml y'amazi . methanol kurwego, kunyeganyeza neza, nahanyuma ubone.
Uburyo bwo kumenya:gukuramo neza 10% yumuti wibisubizo μ l 、 20 μ l.Igisubizo cyikizamini 20 buri μ l.Injira mumazi ya chromatografi, uyimenye, kandi ubare hamwe na logarithm ingero yuburyo bwo hanze yuburyo bubiri.
Kubarwa nkibicuruzwa byumye, ibikubiye muri astragaloside IV (c41h68o14) ntibishobora kuba munsi ya 0.040%
Igikorwa cya farumasi
Ibyingenzi byingenzi bigize Astragalus ni polysaccharide na astragaloside.Astragaloside igabanijwemo astragaloside I, astragaloside II na astragaloside IV.Muri byo, astragaloside IV, astragaloside IV, ifite ibikorwa byiza byibinyabuzima.Astragaloside IV ntabwo ifite gusa ingaruka za polyisikaride ya Astragalus gusa, ahubwo ifite n'ingaruka zimwe ntagereranywa za Astragalus polysaccharide.Imbaraga zayo zikubye inshuro zirenze ebyiri izisanzwe za astragalus polysaccharide, kandi ingaruka zayo zirwanya virusi zikubye inshuro 30 izo polysaccharide ya Astragalus.Kubera ibirimo bike n'ingaruka nziza, bizwi kandi nka "super astragalus polysaccharide".
1.Kongera ubudahangarwa no kurwanya indwara.
Irashobora gukuraho byumwihariko kandi idasobanutse gukuramo imibiri y’amahanga yinjira mu mubiri, igatera ubudahangarwa bwihariye, ubudahangarwa ndetse n’ubudahangarwa, kandi igateza imbere indwara z’umubiri.Irashobora guteza imbere umusaruro wa antibody, kandi ikazamura cyane umubare wa antibody ikora selile nagaciro ka test ya hemolysis.Astragaloside IV irashobora kuzamura cyane urwego rwo guhindura lymphocyte hamwe nigipimo cya E-rosette cyo gutera inkoko zikingira coccidia.Nibikorwa bifatika bya monocyte macrophage sisitemu.Astragaloside IV irashobora kandi kunoza okiside, ibikorwa bya GSH-Px na SOD mu ngingo z'umubiri, kandi igateza imbere imikorere yo kwirinda no gukingira indwara.
2.Ingaruka za virusi.
Ihame ryayo rya virusi: gushishikariza imikorere ya macrophage na T selile, kongera umubare w ingirabuzimafatizo za E-ring, gutera cytokine, guteza imbere kwinjiza interleukin, no gutuma umubiri winyamanswa ubyara interogenous interferon, kugirango ugere ku ntego ya virusi.Ibisubizo byerekanye ko igipimo rusange cyo kurinda astragaloside IV kuri IBD cyari 98.33%, gishobora gukumira no kuvura IBD neza, kandi nta tandukaniro rikomeye ryagereranijwe ugereranije n’umuti mwinshi w’umuhondo w’igi.Astragaloside irashobora kongera imikorere yimisemburo ya antioxydeant mu mubiri, kugabanya ibirimo LP0, kugabanya kwangirika kw amoko ya ogisijeni ikora, bityo bikagabanya umuvuduko w’impfu n’impfu za MD.Irashobora kunoza imikorere yubudahangarwa buke iterwa nibibyimba, igateza imbere gukora ingirabuzimafatizo, kurekura ibintu bitera, kandi ikarinda kwica no kubuza ingirabuzimafatizo ziterwa na peroxidation;Astragaloside a irashobora kubuza ikura rya virusi yibicurane nigikorwa cya sialidase.Ifite ingaruka zikomeye ku mikorere ya virusi ya grippe membrane na adsorption no kwinjira kwa virusi mu ngirabuzimafatizo.Igipimo cy’imfu n’amagi y’inkoko cyaragabanutse cyane, kandi igipimo cyo gutera amagi no gukira neza amagi yari meza cyane ugereranije n’itsinda rishinzwe kugenzura amantadine gusa, kandi ingaruka za Astragalus polysaccharide ntizagaragaye;Astragaloside IV ifite ingaruka zikomeye zo kwica no guhagarika virusi ya nd.Ikigaragara ni uko gukoresha astragaloside IV mbere yo kuvumbura kwandura virusi ya Nd, bityo rero nibyiza gukoresha astragaloside IV igihe kirekire, Avian myeloblastic leukemia (AMB) iminsi 3 broilers AA yagaburiye astragaloside IV yanduye ya virusi ya AMB, irashobora kugabanya umuvuduko w’impfu n’impfu za AMB, kongera LPO mu bice bigize ubudahangarwa nka spleen na thymus, byongera cyane ingaruka zo gusiba intanga na thymus hamwe nizindi ngingo z'umubiri kuri selile yibibyimba ya myeloid.Icya kabiri, astragaloside IV ifite ingaruka zigaragara zo gukumira no kuvura indwara zubuhumekero nka laryngotracheitis yanduye.Koresha.
3. Ingaruka zo kurwanya imihangayiko.
Astragaloside IV irashobora gukumira adrenal hyperplasia na thymus atrophy mugihe cyo kuburira cyo guhangayika, kandi ikarinda impinduka zidasanzwe mugihe cyo guhangana nigihe cyo kunanirwa no guhangayika, kugirango bigire uruhare mukurwanya guhangayika, cyane cyane bifite amategeko abiri akomeye. Ingaruka kuri enzymes murwego rwo guhinduranya intungamubiri, kandi igabanya kandi ikuraho ingaruka ziterwa nubushyuhe kumikorere ya physiologique yumubiri kurwego runaka.
4. Nkumushinga utera imbere.
Irashobora kuzamura metabolisme physiologique ya selile, igatera umuvuduko wamaraso, kongera metabolisme yumubiri winyamaswa, kandi ikagira uruhare mu mirire no kwita kubuzima.Ubushakashatsi bwerekana ko bushobora guteza imbere imikurire ya bifidobacteria na bacteri acide lactique kandi bifite ingaruka za probiotics.
5. Astragaloside IV irashobora kunoza imikorere yumutima.
Komeza kwandura umutima, kurinda myocardium no kurwanya kunanirwa k'umutima.Ifite kandi ingaruka zo kurinda umwijima, anti-inflammatory na analgesic.Irashobora gukoreshwa nkubuvuzi buvura indwara zitandukanye za virusi na bagiteri.
