Cycloastragenol CAS No 78574-94-4
Kugaragaza ibicuruzwa
[izina]:cycloastragalus inzoga
[alias]:triterpenoid cyclic flavonol
[Izina ry'icyongereza]:cycloastragenol
[formulaire ya molekulari]:C30H50O5
[uburemere bwa molekile]:490.71
[CAS No.]:78574-94-4
[uburyo bwo gutahura]:HPLC ≥ 98%
[Ibisobanuro]:20mg 50mg 100mg 500mg 1g (irashobora gupakirwa ukurikije ibyo abakiriya bakeneye)
[imitungo]:iki gicuruzwa ntigifite ibara rya acicular kristal
[imikorere no gukoresha]:Iki gicuruzwa gikoreshwa mukugena ibirimo, kumenyekanisha, kugerageza ibya farumasi, gusuzuma ibikorwa nubundi bushakashatsi bwubushakashatsi.Nkubuyobozi bwakagari, ikizamini cya intragastricike, kugenzura ubuziranenge bwimbere yimiti yimiti, nibindi. Ibikoresho: Astragalus membranaceus (Fisch.) Bge.Imizi yumye
Uburyo bwo Kubika
2-8 ° C, ifunze urumuri kandi ibitswe ku bushyuhe buke.
Icyitonderwa
Ibicuruzwa bigomba kubikwa ku bushyuhe buke.Niba ihuye numwuka igihe kirekire, ibirimo bizagabanuka.
Imiterere ya Chromatografique column inkingi ya chromatografiya: Zorbax rx-c18 (4,6mm) × 150mm) ， 5 μ m phase Icyiciro cya mobile: amazi ya acetonitrile (30:70);Igipimo cyo gutemba: 1.0ml / min, ubushyuhe bwinkingi: 35 ℃, ibipimo bya ELSD: ubushyuhe bwa drift: 105 ℃, umuvuduko wa azote: 2.70ml / min.
Imiterere yumubiri: ubucucike 1.20
Bioactivite ya cycloastragenol
Cycloastragalol ni uruganda rwa triterpene saponin, arirwo Astragalus membranaceus (Fisch.) Hydrolizate yibigize ingirakamaro muri Bunge).Astramembrangenin ifite umutekano mu kanwa kandi ifite ingaruka zitandukanye za farumasi, harimo gukora telomerase, kongera telomere, kurwanya anti-inflammatory na antioxydeant.Astramembrangenin ifite imiti irwanya gusaza.CAG itera ibikorwa bya telomerase muri keratinocytes yumuntu wavutse hamwe ningirangingo z'imbeba kandi bigatera gukora CREB.Astramembrangenin irashobora kugira ingaruka nshya zo kuvura mukwiheba
Ibyiciro bijyanye:
Inzira yerekana inzira >> apoptose >> apoptose
Umwanya wubushakashatsi >> gutwika / ubudahangarwa
Urwego rwubushakashatsi >> indwara zifata ubwonko
Mu Kwiga Vitro:
Ugereranije no kugenzura abitwara mumico ya HEK, proteine yinyenyeri (0-10 μ M; iminsi 3-6) yongereye ingirabuzimafatizo [1].Astramembrangenin （0.3 μ M;Iminota 5-90) yateje fosifora ya CREB muri neuron yibanze ya cortical, kandi imvugo ya CREB yose mubwoko bwombi ntabwo yatewe na CAG [1].Poroteyine yinyenyeri (3) μ M;Amasaha 6-48) arashobora guteza imbere muri vivo signal transduction muri neuron, kongera imvugo ya TERT mRNA, no kwerekana imvugo yiyongereye ya bcl 2 mRNA [1].Imikorere ya selile isuzuma [1] umurongo w'akagari: Ihuriro rya HEK: 1 μ M ， 3 μ M ， 10 μ M igihe cyumuco: iminsi 3-6 ibisubizo: gukura kwakubye kabiri muminsi 6.Isesengura rya blot yo muburengerazuba [1] umurongo w'akagari: kwibanda kwa selile ya neuron: 0.3 μ M igihe cyumuco: iminota 5, iminota 15, iminota 30, iminota 90.Ibisubizo: CAG yateje CREB gukora muri neuron.RT-PCR [1] umurongo w'akagari: kwibanda kuri selile ya neuron: 3 μ M igihe cyumuco: amasaha 6-48 ibisubizo: imvugo ya TERT na Bcl 2 mRNA yariyongereye.
Reba:
[1].Ip FC, n'abandi.Cycloastragenol nikintu gikomeye cya telomerase ikora mumyanya mitsi ya neuronal: ingaruka zo gucunga depression.Neurosignals.2014; 22 (1): 52-63.
[2].Yu Y, n'abandi.Cycloastragenol: Umukandida mushya ushimishije ku ndwara ziterwa n'imyaka.Kwagura Med.2018 Nzeri; 16 (3): 2175-2182.
[3].Izuba C, n'abandi.Cycloastragenol ihuza ibikorwa byo guhagarika no gukwirakwiza muri concanavalin A-iterwa n'imbeba lymphocyte pan-activation moderi.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139.
Ibyiza bya fiziki ya Himiki ya Cycloastragenol
Ubucucike:1.2 ± 0.1 g / cm3
Ingingo itetse:617.2 ± 55.0 ° C kuri 760 mmHg
Ingingo yo gushonga:241.0 kugeza 245.0 ° C.
Inzira ya molekulari:c30h50o5
Uburemere bwa molekile:490.715
Ingingo ya Flash:327.1 ± 31.5 ° C.
Misa nyayo:490.365814
PSA:90.15000
LogP:3.82
Umuvuduko w'amazi:0.0 ± 4.0 mmHg kuri 25 ° C.
Igipimo cyerekana:1.582
Amakuru yumutekano wa Cycloastragenol
Kode yo gutwara ibicuruzwa biteje akaga: nonh kuburyo bwose bwo gutwara
Numero ya RTECS;GX8265000
Kode ya gasutamo: 2942000000
Gasutamo ya Cycloastragalol
Kode ya gasutamo: 2942000000
Cycloastragalol Ubuvanganzo
Cycloastragenol nikintu gikomeye cya telomerase ikora mumyanya mitsi ya neuronal: ingaruka zo gucunga depression.
Neurosignals 22 (1), 52-63, (2014)
Cycloastragenol (CAG) ni aglycone ya astragaloside IV.Byamenyekanye bwa mbere mugihe cyo gusuzuma ibimera bya Astragalus membranaceus kubintu bikora bifite imiti igabanya ubukana.Ubu bushakashatsi de ...
Ushinzwe itumanaho rya telomerase ahagarika kwangiza ibihaha muburyo bwa murine bwa idiopathic pulmonary fibrosis.
SHAKA UMWE 8 (3), e58423, (2013)
Kugaragara kw'indwara zijyanye no kudakora neza kwa telomere, harimo sida, anemia aplastique na fibrosis yo mu bihaha, byashimangiye inyungu mu bakora telomerase.Turatanga raporo iranga n ...
Telomerase ishingiye kuri farumasi yongera imikorere ya virusi ya CD8 + T ya lymphocytes.
J. Immunol.181 (10), 7400-6, (2008)
Telomerase ihinduranya yandukura ADN ya telomere kumpera ya chromosomes yumurongo kandi ikarinda gusaza kwa selile.Bitandukanye na selile zisanzwe zisanzwe, zerekana bike cyangwa nta bikorwa bya telomerase, immun ...
Icyongereza Alias cya Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy -, (3β, 6α, 9β, 16β, 20R, 24S) -
Astramembrangenin
(3β, 6α, 9β, 16β, 20R, 24R) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy -, (3β, 6α, 9β, 16β, 20R, 24R) -
(3β, 6α, 9β, 16β, 20R, 24S) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
