Ibicuruzwa

Ibisobanuro:Danshensu nigice cyingenzi cya Saliviya miltiorrhiza, ishobora gukora inzira ya Nrf2 yerekana inzira kandi ikarinda sisitemu yumutima.
Ibyiciro bifitanye isano: inzira yerekana inzira >> autophagy >> autophagy
Inzira y'ibimenyetso >> NF- κ B inzira yerekana ibimenyetso >> keap1-nrf2
Urwego rwubushakashatsi >> Indwara yumutima
Ibicuruzwa bisanzwe >> acide benzoic

Mu Kwiga Vitro:Danshensu (DSS) yagabanije cyane urwego rwimisemburo ya marikeri (creatine kinase na lactate dehydrogenase) yimisemburo ya coronari isohoka hamwe nubunini bwa infiyasiyo ya myocardial.Ibi birashobora guteza imbere cyane kugarura imikorere yumutima nyuma yimvune ya I / R.DSS ifite kandi ibikorwa byo gusiba ROS kandi iteza imbere ibikorwa bya antioxydants ya endogenous nka SOD, injangwe, MDA, GSH-Px na HO-1 ukoresheje ibintu bya kirimbuzi erythrocyte-2 bifitanye isano na 2 (Nrf2) byerekana inzira yahujwe na Akt na ERK1.2 mu isesengura ryiburengerazuba [2].

Mu Kwiga Vivo:ubuvuzi bukabije hamwe numuti umwe wa Danshensu ntabwo byahinduye plasma tHcy mumbeba hamwe na tHcy isanzwe.Ibinyuranye, Danshensu yagabanije cyane tHcy mu mbeba hamwe na tHcy yazamutse.Urwego rwo hejuru rwa sisitemu na glutathione nyuma yo kuvurwa na Danshensu byerekana ko ingaruka zayo zo kugabanya tHcy ari ukongera ibikorwa byinzira nyabagendwa [1].

Ubushakashatsi ku nyamaswa:imiti yose yashongeshejwe muri saline usibye tolcapone yashonga muri saline irimo 20% (V / V) peg 200. Mugihe cyubushakashatsi, imbeba zafunzwe ijoro ryose hanyuma zishirwa mumatsinda atandukanye.Nyuma ya anesthesia ya ether, abagera kuri 200 bakuwe mumaraso ya orbital sinus μ L, hanyuma yanduza vuba inzoga hanyuma ukande hamwe na pamba.Amaraso yahise akusanyirizwa mu miyoboro ya polypropilene irimo sodium ya heparin hanyuma igashyirwa kuri 5000 g kuri 5 ° C mu minota 3.Urugero rwa plasma rwateguwe rwabitswe kuri - 20 ℃ kandi rusesengurwa mu masaha 48.

Reba:[1] YG Cao, n'abandi.Ingaruka zingirakamaro za danshensu, igice cyingenzi cya Saliviya miltiorrhiza, kuri metabolism ya homocysteine ​​ikoresheje inzira ya trans-sulphuration mumbeba.Br J Pharmacol.2009 Jun;157 (3): 482–490.

[2].Yu J, n'abandi.Danshensu irinda umutima witaruye gukomeretsa ischemia reperfusion binyuze mumikorere ya Akt / ERK1 / 2 / Nrf2.Int J Clin Yagutse Med.2015 Nzeri 15;8 (9): 14793-804.