Dimethylfraxetin; 6,7,8-Trimethoxycoumarin
Kugaragaza ibicuruzwa
Izina Rusange:ivu ryibiti
CAS No.:6035-49-0
Ubucucike:1.2 ± 0.1 g / cm3
Inzira ya molekulari:C12H12O5
MSDS:N / A.
Izina ry'icyongereza:dimethylfraxetin
Uburemere bwa molekile:236.221
Ingingo yo guteka:408.0 ± 45.0 ° C kuri 760 mmHg
Ingingo yo gushonga:104-105 º C.
Flash Point:184.3 ± 28.8 ° C.
Igikorwa cyibinyabuzima cya dimethylfraxetin
Ibisobanuro:dimethylfraxetin ni karubone ya anhydrase inhibitor ifite agaciro ka Ki 0.0097 μ M。
Ibyiciro bifitanye isano:
inzira yinzira >> enzyme ya metabolike / protease >> anhydrase ya karubone
Urwego rwubushakashatsi >> kanseri
Ibicuruzwa bisanzwe >> acide benzoic
Intego:ki: 0.0097 μ M (Anhydrase ya Carbone) [1]
Mu bushakashatsi bwa vitro:muri CA I, uruganda rumwe rukomeye ni dimethylfluoxetine (compound 17), nanomolar CA I inhibitor.Iyi trimethoxycoumarin ningirakamaro cyane muri NP coumarin muri isozymes esheshatu CA muri ubu bushakashatsi [1].
Kinase:mbere yo kwiyemeza, inhibitor (harimo na dimethylerythromycin) hamwe nigisubizo cya enzyme byashyizwe mubushyuhe bwicyumba cyamasaha 6 kugirango habeho gukora enzyme inhibitor [1]
Reba:[1] Davis RA, n'abandi.Ibicuruzwa bisanzwe coumarine ibuza anhydrases ya karubone yabantu.Bioorg Med Chem.2013 Werurwe 15;21 (6): 1539-43.
Dimethylfraxetin
Ubucucike:1.2 ± 0.1 g / cm3
Ingingo yo guteka:408.0 ± 45.0 ° C kuri 760 mmHg
Ingingo yo gushonga:104-105 º C.
Inzira ya molekulari:c12h12o5
Uburemere bwa molekile:236.221
Flash Point:184.3 ± 28.8 ° C.
Misa nyayo:236.068466
PSA ：57.90000
LogP ：1.75
Umuvuduko w'amazi:0.0 ± 1.0 mmHg kuri 25 ° C.
Igipimo cyerekana:1.545
Dimethylfraxetin Amakuru Yumutekano
Ibisobanuro (Europe): 22
Umutekano (Uburayi):22-45
Kode ya gasutamo:293220990
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Gasutamo ya Dimethylfraxetin
Kode ya gasutamo:293220990
Incamake y'Ubushinwa:293220990 Izindi lactone Igipimo cy'umusoro ku nyongeragaciro: 17.0% Igipimo cyo kugabanyirizwa imisoro: 13.0% Ibisabwa: ntamahoro ya MFN: 6.5% Igiciro rusange: 20.0%
Ibimenyesha:izina ryibicuruzwa, ibihimbano, ibirimo n'intego
Incamake ：2932209090. izindi lactone.TVA: 17.0%.Igipimo cyo kugabanyirizwa imisoro: 13.0%..Igiciro cya MFN: 6.5%.Igiciro rusange: 20.0%
Icyongereza Alias Ya Dimethylfraxetin
6,7,8-trimethoxychromen-2-imwe
6,7,8-Trimethoxy-2H-chromen-2-imwe
2H-1-Benzopyran-2-imwe, 6,7,8-trimethoxy-
