Fraxin;Paviin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Amakuru y'ingenzi
CAS No.:524-30-1 [1]
EINECS Oya.:208-355-5
Inzira ya molekulari:c16h18o10
Uburemere bwa molekile:370.3081
Imiterere ya molekulari:(Ishusho 1)
Ibyiza:Umuhondo woroshye wa acicular kristal cyangwa flake kristal.
Ubucucike:1.634g / cm3
Ingingo yo guteka:722.2 ° C kuri 760 mmHg
Flash Point:267 ° C.
Umuvuduko w'amazi:6.87e-22mmhg kuri 25 ° C.
Bioactivite ya Fraxin
Ibisobanuro:Fraxin irashobora kwitandukanya na Acer tegmentosum, F. ornus na a.hippocastanum.Ni glycoside ya fraxine [1] kandi ifite ibikorwa bya antioxydeant, anti-inflammatory na anti metastasis.Fraxin yerekana ibikorwa bya antioxydeant ibuza cyclic adenylate phosphodiesterase [2].
Intego:cyclo AMP phosphodiesterase enzyme [2]
Mu Kwiga Vitro:Fraxin (100 μ M) Ntabwo ifite cytotoxicity kuri selile Hep G2.Fraxin yibitekerezo bya cytotoxique byagabanije cyane t-BHP itera umusaruro wa ROS muburyo buterwa na dose [1].Fraxin (0,5 mm) irashobora gukuramo radicals yubusa kandi ikagira ingaruka za cytoprotective kuri H2O2 ihangayikishijwe na okiside itera imbaraga [2].
Mu bushakashatsi bwa vivo:Fraxin (50 mg / kg, PO) yahagaritse cyane CCl4 itera kuzamuka kwa ALT na AST.Fraxin (10 na 50 mg / kg, PO) yagabanije cyane urwego rwa GSSG (1.7 ± 0.3 na 1.5 ± 0.2 nm / g umwijima) ugereranije n’urwego rwa GSSG mu itsinda rivura CCl4
Reba:.Fraxin (50 mg / kg, po) irabuza cyane CCl4 iterwa na ALT na AST.Fraxin (10 na 50 mg / kg, po) igabanya cyane urwego rwa GSSG (1.7 ± 0.3 na 1.5 ± 0.2 nM / g umwijima) ugereranije n’urwego rwa GSSG rwo mu itsinda ryavuwe na CCl4 [1].
[2].Whang WK, n'abandi.Ibintu bisanzwe, fraxine nubumara bijyanye na fraxine birinda selile guhangayika.Kwagura Mol Med.2005 Ukwakira 31; 37 (5): 436-46.
