CAS ya Galangin No 548-83-4
Imiterere yumubiri nubumara
Alias:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Izina ry'icyongereza:galangin,
Icyongereza bita:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-fenylchromen-4-imwe
Imiterere ya molekulari
1. Indangantege ya Molar: 69.55
2. Ingano ya molari (m3 / mol): 171.1
3. Ingano yihariye ya Isotonic (90.2k): 519.4
4. Ubushyuhe bwo hejuru (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Ubuhanga bwo Kubara
1. Agaciro kerekana kubara hydrophobique kubara (xlogp): Ntayo
2. Umubare w'abaterankunga ba hydrogen: 3
3. Umubare wa reseptor ya hydrogène yakira: 5
4. Umubare wimiti ihindagurika: 1
5. Umubare wa tautomers: 24
6. Ubuso bwa topologiya ya polarite yubuso 87
7. Umubare wa atome ziremereye: 20
8. Amafaranga yo hejuru: 0
9. Ingorabahizi: 424
10. Umubare wa atome ya isotopi: 0
11. Menya umubare wa stereocenters ya atome: 0
12. Umubare wa stereomicente ya atomike itazwi: 0
13. Menya umubare wububiko bwa chimique stereocenters: 0
14. Umubare wimiti itamenyekana ya stereocenters: 0
15. Umubare wimigabane ya covalent: 1
Igikorwa cya farumasi
Galangin irashobora guhindura Salmonella typhimurium TA98 na TA100 kandi ifite ingaruka za virusi
Mu Kwiga Vitro
Galangin yabujije catabolism ya DMBA muburyo bukabije.Galangin kandi yabujije ishingwa rya DMBA-ADN kandi irinda DMBA itera gukura kwingirabuzimafatizo.Mu ngirabuzimafatizo na microsomes zitandukanijwe na selile zivuwe na DMBA, galangin yatanze umusaruro ushimishije wo kubuza ibikorwa CYP1A1 byapimwe nigikorwa cya ethoxypurine-o-deacetylase.Isesengura ryibintu byabujijwe kubishushanyo mbonera byombi byerekanaga ko galangin yabujije ibikorwa CYP1A1 muburyo budahiganwa.Galangin itera kwiyongera kurwego rwa CYP1A1 mRNA, byerekana ko ishobora kuba agoniste ya reseptor ya hydrocarbon ya aromatic, ariko ikabuza CYP1A1 mRNA (TCDD) iterwa na DMBA cyangwa 2,3,5,7-tetrachlorodibenzo-p-dioxine.Galangin irabuza kandi DMBA cyangwa TCDD iterwa no kwandukura abanyamakuru barimo CYP1A1 promoteri [1].Ubuvuzi bwa Galangin bwabujije ikwirakwizwa ry'uturemangingo kandi butera autofagy (130) μ M) Na apoptose (370 μ M） particular By'umwihariko, kuvura galangine mu tugari twa HepG2 byatumye (1) kwirundanya kwa autofagosomes, (2) byongera urugero rwa microtubule ifitanye isano na poroteyine y'urumuri rwa poroteyine. 3, na (3) byiyongereyeho ijanisha rya selile hamwe na vacuole. Imvugo ya P53 nayo yariyongereye. Galangin yateje autofagy yatewe no kubuza p53 mu tugari twa HepG2, kandi gukabya gukabije kwa p53 mu tugari twa Hep3B byagaruye ijanisha ryinshi rya vacuole selile zatewe na galangine kurwego rusanzwe. [2].
Ubushakashatsi bwakagari
Ingirabuzimafatizo (5.0 × 103) zatewe kandi zivurwa hamwe na galangine zitandukanye mu masahani 96 meza mu bihe bitandukanye.Wongeyeho 10 μ L ya 5 mg / ml MTT igisubizo kugirango umenye umubare w'ingirabuzimafatizo muri buri riba.Nyuma yubushakashatsi kuri 37 ℃ kumasaha 4, selile zashongeshejwe mumuti 100% zirimo 20% SDS na 50% dimethylformamide μ L.Ubucucike bwa optique bwapimwe hakoreshejwe varioskan flash umusomyi wa ecran ya ecran kuri metero 570 nm hamwe nuburebure bwa 630 nm.
