Hyperoside ； Hypercin Cas No 482-36-0
Amakuru yibiyobyabwenge
[izina ryibicuruzwa] hypericin
[Izina ry'icyongereza] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[formulaire ya molekulari] c21h20o12
[uburemere bwa molekile] 464.3763
[C nka Oya] 482-36-0
[gutondekanya imiti] flavonoide
[isoko] Hypericum perforatum L.
[Ibisobanuro]> 98%
[Ijambo ry'umutekano] 1. Ntugahumeke umukungugu.2.Mu gihe habaye impanuka cyangwa bitagushimishije, shaka ubuvuzi bwihuse (erekana ikirango cyacyo niba bishoboka).
[Pharmacological efficacy] Hypericine ikwirakwizwa cyane.Nibicuruzwa byingenzi bifite ibikorwa bitandukanye byumubiri, nka anti-inflammatory, antispasmodic, diuretic, kugabanya inkorora, kugabanya umuvuduko wamaraso, kugabanya cholesterol, kugabanuka kwa poroteyine, analgesie yo mu karere no hagati, hamwe ningaruka zo gukingira kumitsi nubwonko bwubwonko.
[Imiterere yumubiri nubumashini] Icyatsi cyumuhondo acicular kristal.Ingingo yo gushonga ni 227 ~ 229 ℃, naho guhinduranya optique ni - 83 ° (C = 0.2, pyridine).Irashobora gushonga byoroshye muri Ethanol, methanol, acetone na pyridine kandi irahagaze mubihe bisanzwe.Ifata ifu ya hydrochloric acide magnesium kugirango itange cheri itukura, na chloride ferric ikora icyatsi, α- Naphthol reaction yari nziza.
[Risk terminology] Byangiza niba byamizwe.
Igikorwa cya farumasi
1. Hypericine ifite ingaruka zikomeye zo gusesengura zaho, zifite intege nke kuruta morphine, zikomeye kuruta aspirine, kandi ntizishingiye.Hypericin ni ubwoko bushya bwa analgesic yaho Mugihe kimwe,
2. Hypericine igira ingaruka nziza zo kurinda myocardial ischemia-reperfusion, ubwonko bwubwonko-reperfusion hamwe nubwonko bwubwonko.
3. Hypericine ifite ingaruka zo kurwanya inflammatory: nyuma yo guterwa umupira wubwoya, imbeba zatewe inshinge 20mg / kg buri munsi muminsi 7, ibyo bikaba byabujije cyane inzira yo gutwika.
4. Ifite ingaruka zikomeye zo kurwanya.
5. Kwishyira hamwe.
6. Kubuza cyane kugabanya aldose reductase birashobora kuba ingirakamaro mukurinda indwara ya diabete.
Ingaruka zo gukingira ischemia myocardial
Hypericine irashobora kugabanya umuvuduko wa apoptose ya cardiomyocytes iterwa na hypoxia reoxygenation, ikabuza irekurwa rya lactate dehydrogenase, kunoza imikorere ya myocardial superoxide dismutase (SOD) mu mbeba hamwe na myocardial ischemia-reperfusion, kugabanya umusaruro wa malondialdehyde (MDA), kubuza umusaruro wa malondialdehyde (MDA) kwiyongera kwa fosifokine ya myocardial (CPK) muri serumu, no kugabanya ishingwa rya ogisijeni yubusa ya radical na nitric oxyde yubusa ya radical, Kugirango rero urinde myocardium kandi ugabanye imvune yumutima ndetse na cardiomyocyte apoptose iterwa na ischemia-reperfusion.
Ingaruka zo gukingira ischemia cerebral
Hypericine irashobora guhagarika neza igabanuka ryibintu bya formazan mu bice byubwonko nyuma yimvune ya hypoxia glucose yabuze reperfusion, kongera umubare wa neuron ukiriho muri cortex na striatum yibice byubwonko mubice bya ischemic, kandi bigatuma morphologie ya neuron yuzuye kandi ikwirakwizwa neza.Irinde igabanuka ryibikorwa bya neuronal biterwa na hypoxia glucose yabuze reperfusion.Kubuza kugabanuka kwibikorwa bya SOD, LDH na glutathione peroxidase (GSHPx).Uburyo bwabwo bushobora kuba bufitanye isano no gukata radical yubusa, kubuza Ca2 kwinjira no kurwanya lipide peroxide.
Ingaruka zo gukingira umwijima na mucosa gastric
Hypericine igira ingaruka zigaragara zo kurinda umwijima na mucosa gastric.Uburyo bwayo bufitanye isano na antioxydeant, iteza imbere kugaruka kwa N0 kurwego rusanzwe no kongera ibikorwa bya SOD.
Ingaruka zo kurwanya antispasmodic
Ubushakashatsi bwerekanye ko ingaruka zidasanzwe za hypericine ziterwa no kugabanya Ca 2 mu mitsi ibabaza.Muri icyo gihe, hypericine irashobora kubuza Ca 2 kwinjira guterwa na potasiyumu nyinshi, byerekana ko hypericine nayo ihagarika umuyoboro wa Ca mu mitsi.Birasabwa kandi ko hypericine ishobora kuba umuyoboro wa Ca 2.Indorerezi zishingiye ku mavuriro zerekana ko inshinge ya hypericine isa na atropine mu kuvura indwara ya dysmenorrhea.Usibye ingaruka nkeya zasinziriye, ntabwo ifite ingaruka mbi zisanzwe nka tachycardia, mydriasis hamwe no gutwika.Nibyiza birwanya antispasmodic na analgesic.
Ingaruka ya Hypolipidemic
Hypericine irashobora kugabanya cyane serumu TC no kongera igipimo cya HDL / TC mu mbeba zifite amavuta menshi, byerekana ko hypericine ishobora kugabanya cholesterol, kugenga lipide yamaraso, no kunoza imikorere ya HDL na serumu SOD mu mbeba.Izi ngaruka zirashobora kugabanya cyane kwangirika kwa superoxide yubusa kuri endotelium yimitsi iva muri hyperlipidemiya, kandi ifasha kubora no guhinduranya metabolisme ya lipide peroxide kugirango irinde endotelium yimitsi.
Kongera imikorere yubudahangarwa
Hypericine ku kigero cya 300 mg / kg na mg / kg 150 muri vivo irashobora kubuza cyane indangagaciro ya thymus, ikwirakwizwa rya lymphocytes ya spleen T na B hamwe na fagocytose ya macrophage ya peritoneyale;Kuri mg / kg 59, byongereye cyane ikwirakwizwa rya lymphocytes spleen T na B hamwe na fagocytose ya macrophage ya peritoneal.Hypericine ku kigero cya 50 ~ 6,25 ml muri vitro irashobora guteza imbere cyane ikwirakwizwa rya lymphocytes T na B kandi ikongerera ubushobozi T lymphocytes T gukora IL-2;Hypericine kuri 6.25 g / ml yongereye cyane ubushobozi bwa macrophage yimbeba ya peritoneyale kuri fagocytize neutrophile, kuva kuri 12.5 kugeza kuri 3.12 μ G / ml byongereye cyane ubushobozi bwa macrophage yimbeba peritoneal kurekura No.
Ingaruka zo kurwanya indwara
Gukora Hypothalamic pituitar adrenal (HPA) ni ihinduka ry’ibinyabuzima ku barwayi bafite ihungabana rikomeye, rikarangwa no gusohora cyane imisemburo ya adrenocorticotropique (ACTH) na cortisol.Hypericine irashobora kugenga imikorere ya axis ya HPA no kugabanya urwego rwa ACTH na corticosterone, kugirango igire uruhare rwo kurwanya antidepressant.
Ibiyobyabwenge Byarangiye
Ciwujia capsule
Acanthopanax senticosus capsule ni imyiteguro hamwe na Acanthopanax senticosus stem hamwe nibibabi byamababi nkibikoresho fatizo.Ibice nyamukuru ni flavonoide, aho hypericine aricyo kintu cyingenzi kigize amababi ya Acanthopanax senticosus.
Ibimenyetso nyamukuru: guteza imbere gutembera kwamaraso no gukuraho ihagarikwa ryamaraso.Ikoreshwa mu gatuza arthralgia n'indwara z'umutima ziterwa no guhagarara kw'amaraso.Ibimenyetso birimo ububabare bwo mu gatuza, gukomera mu gatuza, guhinda umushyitsi, hypertension, n'ibindi ni ukubura impyiko n'impyiko n'amaraso hamwe na Yin.
Xinan capsule
Nimyiteguro ikozwe mumababi ya hawthorn, ikungahaye kuri flavonoide, aho hypericine nikimwe mubice byingenzi.
Ibimenyetso byingenzi: kwagura sisitemu yumutima nimiyoboro yimitsi, kunoza amaraso ya myocardial no kugabanya lipide yamaraso.Ikoreshwa mu kuvura indwara z'umutima zifata umutima, pectoris ya angina, gukomera mu gatuza, palpitation, hypertension, n'ibindi.
Qiyue Jiangzhi tablet
Ibinini bya Qiyue Jiangzhi ni imiti gakondo yo mu Bushinwa imiti igabanya lipide igabanya gukuramo ibice bifatika by’ubuvuzi gakondo bw’Abashinwa nka hawthorn (enucleated) na Astragalus membranaceus.Kimwe mu bintu by'ingenzi bigize ingona ni flavonoide, aho hypericine iba nyinshi.
Ibimenyetso nyamukuru: kugabanya lipide yamaraso no koroshya imiyoboro yamaraso.Ikoreshwa mukuzamura umuvuduko wamaraso no kurwanya arththmia na hyperlipidemia.
Xinxuening tablet
Ibinini bya Xinxuening ni imyiteguro ivanze ikozwe mubuvuzi gakondo bwabashinwa nka hawthorn na pueraria.Hawthorn nubuvuzi bwemewe bwishyaka ryacu.Harimo aside ya ursolike, Vitexin rhamnoside, hypericine, aside citric, nibindi, hypericine niyo ngingo nyamukuru.
Ibimenyetso nyamukuru: guteza imbere umuvuduko wamaraso no gukuraho ihagarikwa ryamaraso, gutobora hamwe no kugabanya ububabare.Ikoreshwa mu gatuza arthralgia na vertigo iterwa no guhagarara k'amaraso y'umutima hamwe no gufatanya ubwonko, hamwe n'indwara z'umutima, hypertension, angina pectoris na hyperlipidemia.
Yukexin capsule
Yukexin capsule ni imiti gakondo y’Abashinwa yateguwe kuva mu nyandiko ya kera, igizwe na Hypericum perforatum, intungamubiri ya jujube yo mu gasozi, igishishwa cya Albizzia, Gladiolus n’indi miti gakondo y’Abashinwa.Ifite cyane cyane hypericine, quercetin, quercetin, aside chlorogene, aside cafeque, yimaning, hypericine nibindi bice.
Ibimenyetso nyamukuru: kwiheba mumutwe biterwa no guhagarika umwijima qi numutima mubi.
