Isoliquiritin Apioside
Gushyira mu bikorwa Isoliquiritin Apioside
Isoliquiritin apioside, igice gitandukanijwe na radiyo ya glycorrhizae, cyagabanije cyane PMA itera kwiyongera mubikorwa bya MMP9 kandi ibuza PMA gutera MAPK na NF- κ B.Isoliquitin apioside ibuza gutera na angiogenezi ya kanseri ya kanseri na selile endothelia.
Izina rya Isoliquiritin Apioside
Izina ry'Ubushinwa:Isoliquiritin Apioside
Izina ry'icyongereza:(E) -3- [4 - [(2S, 3R, 4S, 5S, 6R) -3 - oxy-4,5-dihydroxy-6- (hydroxymethyl) oxan-2-yl] oxyphenyl] -1- (2,4-dihydroxyphenyl) prop-2-en-1-imwe
Bioactivite ya Isoliquiritin Apioside
Ibisobanuro:isoliquitin apioside, igice gitandukanijwe na radiyo ya glycorrhizae, byagabanije cyane PMA itera kwiyongera mubikorwa bya MMP9 kandi ibuza PMA gutera MAPK na NF- κ B.Isoliquitin apioside ibuza gutera na angiogenezi ya kanseri ya kanseri na selile endothelia.
Bifitanye isanoCategories:urwego rw'ubushakashatsi >> kanseri
Inzira y'ibimenyetso >> MAPK / ERK inzira y'ibimenyetso >> p38 MAPK
Inzira yerekana inzira >> metabolike enzyme / protease >> MMP
Intego:MMP9
NF-κB
p38 MAPK
Mu bushakashatsi bwa vitro:isorlicine irashobora guhagarika neza ibikorwa bya MMP-9 ya PMA itera selile HT1080.Isoglycyrrhizin apigenin igabanya ubwiyongere bw'umusaruro wa MMP-9 mu tugari twa HT1080 uterwa na PMA, ufite ubushobozi bwo kurwanya metastasis na anti angiogenezi mu ngirabuzimafatizo y'ibibyimba ndetse na selile endothelia, kandi nta cytotoxicity ifite [1].
Reba:[1].Kim A1, n'abandi.Isoliquiritin Apioside Irwanya muri vitro Invasiveness na Angiogenezi yingirangingo za kanseri na selile Endothelia. Imbere ya Pharmacol.2018 Ukuboza 10; 9: 1455.
Imiterere ya physiochemiki ya Isoliquiritin Apioside
Ubucucike: 1,6 ± 0.1 g / cm3
Ingingo yo guteka: 901.0 ± 65.0 ° C kuri 760 mmHg
Inzira ya molekulari: c26h30o13
Uburemere bwa molekile: 550.509
Ingingo yerekana: 301.9 ± 27.8 ° C.
Misa nyayo: 550.168640
PSA: 215.83000
LogP: 1.96
Umuvuduko wamazi: 0.0 ± 0.3 mmHg kuri 25 ° C.
Igipimo cyangirika: 1.709
Icyongereza bita Isoliquiritin Apioside
2-Propen-1-imwe, 1- (2,4-dihydroxyphenyl) -3- [4 - [[2-O - [(2S, 3R, 4R) -tetrahydro-3,4-dihydroxy-4- (hydroxymethyl ) -2-furanyl] -β-D-glucopyranosyl] oxy] phenyl] -, (2E) -
3 - [(1E) -3- - (hydroxymethyl) tetrahydro-2-furanyl] -β-D-glucopyranoside
Neolicuroside
