page_head_bg

Ibicuruzwa

Naringenin Cas No 480-41-1

Ibisobanuro bigufi:

Naringenin ni ibinyabuzima bisanzwe hamwe na molekuline c15h12o5.Ni ifu yumuhondo, gushonga muri Ethanol, ether na benzene.Ikoti ry'imbuto ahanini rituruka kuri cashew nuts ya lacqueraceae.Ikoreshwa mu gusesengura ubuziranenge n'ubwinshi bw'ubuvuzi gakondo bw'Abashinwa burimo naringin [1].Ku mwanya wa karubone 7, ikora glycoside hamwe na neohesperidin, yitwa naringin.Biraryoshe cyane.Iyo ibice bya dihydrochalcone byakozwe mugukingura impeta na hydrogenation mubihe bya alkaline, ni uburyohe buryoshye hamwe nuburyohe bwikubye inshuro 2000 ubwa sucrose.Hesperidin ni nyinshi mu gishishwa cya orange.Ikora glycoside hamwe na rutin kumwanya wa karubone 7, bita hesperidin, ikanakora glycoside hamwe na rutin kumwanya wa karubone 7- Neohesperidin ni glycoside ya neohesperidin.


Ibicuruzwa birambuye

Ibicuruzwa

Intangiriro

Igikorwa cy'umusaruro:byuzuzwa cyane cyane no gukuramo inzoga, gukuramo, chromatografiya, korohereza ibintu nibindi bikorwa.

Cas No.480-41-1

Ibirimo:98%

Uburyo bw'ikizamini:HPLC

Imiterere y'ibicuruzwa:cyera acicular kristu, ifu nziza.

Imiterere yumubiri nubumashini:gushonga muri acetone, Ethanol, ether na benzene, hafi yo kudashonga mumazi.Ifu ya magnesium hydrochloride ifu yari cheri itukura, reaction ya sodium tetrahydroborate yari umutuku wijimye, kandi reaction ya molish yari mbi.

Ubuzima bwa Shelf:Imyaka 2 (by'agateganyo)

Inkomoko y'ibicuruzwa

Amacardi um occidentale L. intoki nigishishwa cyimbuto, nibindi;Prunus yedoensis mats Bud, Mei P. mumesiebet Zucc Bud.

Igikorwa cya farumasi

Naringin ni aglycone ya naringin kandi ni iya dihydroflavonoide.Ifite imirimo ya antibacterial, anti-inflammatory, radical scavenging free, antioxidant, inkorora na exporant, kugabanya lipide yamaraso, kurwanya kanseri, anti-tumor, antispasmodic na cholagogic, gukumira no kuvura indwara zumwijima, kubuza kwanduza platine, kurwanya ateriyose hamwe n'ibindi.Irashobora gukoreshwa cyane mubuvuzi, ibiryo nibindi bice.

Antibacterial
Ifite antibacterial ikomeye kuri Staphylococcus aureus, Escherichia coli, dysentery na bacillus tifoyide.Naringin nayo igira ingaruka ku bihumyo.Gutera 1000ppm kumuceri birashobora kugabanya kwandura Magnaporthe grisea 40-90%, kandi nta burozi bifite kubantu n'amatungo.

Kurwanya indwara
Imbeba zatewe inshinge 20mg / kg buri munsi, ibyo bikaba byarabujije cyane uburyo bwo gutwika bwatewe no gushira umupira wubwoya.Galati n'abandi.Byagaragaye ko buri tsinda rya dose ya naringin ryagize ingaruka zo kurwanya inflammatory hakoreshejwe igeragezwa ryibinini byamatwi, kandi ingaruka zo kurwanya inflammatory ziyongereye hamwe no kwiyongera kwinshi.Igipimo cyo kubuza itsinda ryinshi rya dose ryari 30.67% hamwe nubunini bwubunini na 38% hamwe nuburemere bwibiro.[4] Feng Baomin n'abandi.Indwara ya dermatite yicyiciro cya 3 mu mbeba nuburyo bwa DNFB, hanyuma itanga naringin kumunwa muminsi 2 ~ 8 kugirango turebe igipimo cyo kubuza icyiciro cyihuse (IPR), icyiciro cyatinze (LPR) na ultra late phase (VLPR).Naringin irashobora guhagarika neza ugutwi kwamatwi ya IPR na VLPR, kandi ifite agaciro kiterambere ryiterambere mukurwanya inflammatory.

Amategeko agenga ubudahangarwa
Naringin ikomeza kuringaniza umuvuduko ukabije wa okiside mugihe runaka no mukarere runaka muguhuza imigendekere ya electron muri mitochondria.Kubwibyo, imikorere yubudahangarwa bwa naringin iratandukanye na gakondo yoroshye yo kongera ubudahangarwa cyangwa immunosuppressants.Ikiranga ni uko ishobora kugarura imiterere y’ubudahangarwa (imiterere y’indwara) ku buryo busanzwe bwo kuringaniza ubudahangarwa bw'umubiri (imiterere ya physiologique), Aho kugira ngo umuntu yongere cyangwa abuze ubudahangarwa bw'umubiri.

Kugenga imihango y'abagore
Naringin afite ibikorwa bisa nibiyobyabwenge bitari steroidal anti-inflammatory.Irashobora kugabanya synthesis ya prostaglandine PGE2 muguhagarika cyclooxygenase Cox, kandi ikagira uruhare rwa antipyretike, analgesic no kugabanya umuriro.
Ukurikije estrogene nkingaruka za naringin, naringin irashobora gukoreshwa mubuvuzi bwo gusimbuza estrogene kubagore nyuma yo gucura kugirango birinde ingaruka mbi ziterwa no gukoresha estrogene igihe kirekire.

Ingaruka ku mubyibuho ukabije
Naringin ifite ingaruka zo kuvura kuri hyperlipidemiya n'umubyibuho ukabije.
Naringin irashobora guteza imbere cyane plasma ya cholesterol nyinshi, TG (triglyceride) hamwe na aside irike yubusa ku mbeba zifite umubyibuho ukabije.Byagaragaye ko naringin ishobora kugenzura monocyte peroxisome prolifator ikora reseptor ikora imbeba zifite amavuta menshi δ , Kugabanya urugero rwa lipide yamaraso.
Binyuze mu bigeragezo bivura, byagaragaye ko abarwayi bafite hypercholesterolemia bafashe capsule imwe irimo 400mg naringin buri munsi mu byumweru 8.Ubunini bwa cholesterol ya TC na LDL muri plasma bwaragabanutse, ariko ubukana bwa cholesterol ya TG na HDL ntabwo bwahindutse cyane.
Mu gusoza, naringin irashobora kunoza hyperlipidemiya, ibyo bikaba byemejwe neza mubushakashatsi bwinyamaswa no mubigereranyo byubuvuzi.

Gukuraho radicals yubusa na antioxyde
DPPH (dibenzo isharira acyl radical) ni radical yubusa.Ubushobozi bwayo bwo gushakisha radicals yubusa irashobora gusuzumwa na 517 nm yo kwinjirira kwayo.[6] Kroyer yize ku ngaruka za antioxydeant ya naringin akoresheje ubushakashatsi kandi yemeza ko naringin igira ingaruka za antioxydeant.[7] Zhang Haide n'abandi.Yagerageje inzira ya lipide peroxidisation ya LDL ukoresheje colorimetry hamwe nubushobozi bwo kubuza okiside ya LDL.Naringin yibeshya cyane Cu2 + ibinyujije mumatsinda yayo 3-hydroxyl na 4-karubone, cyangwa itanga proton na neutre radical yubusa, cyangwa irinda LDL kwirinda lipide peroxidisation ikoresheje okiside yonyine.Zhang Haide nabandi basanze naringin ifite ingaruka nziza ya radical scavenging kuburyo bwa DPPH.Ingaruka yubusa ya radical scavenging irashobora kugerwaho na hydrogen okiside ya naringin ubwayo.[8] Peng Shuhui n'abandi.Yakoresheje icyitegererezo cyubushakashatsi bwa riboflavin yoroheje (IR) - nitrotetrazolium chloride (NBT) - spekitifotometometrie kugirango yerekane ko naringin igira ingaruka zigaragara ku bwoko bwa ogisijeni O2 -, bukomeye kuruta ubwa acide acorbike mu kugenzura neza.Ibyavuye mu bushakashatsi bw’inyamaswa byerekanye ko naringin yagize ingaruka zikomeye zo kubuza lipide peroxidisation mu bwonko bwimbeba, umutima numwijima, kandi ishobora kuzamura cyane ibikorwa bya superoxide disutase (SOD) mumaraso yose yimbeba.

Kurinda umutima
Naringin na naringin birashobora kongera ibikorwa bya reductase ya acetaldehyde (ADH) na acetaldehyde dehydrogenase (ALDH), kugabanya ibiri muri triglyceride mu mwijima na cholesterol yuzuye mu maraso no mu mwijima, byongera ibipimo bya cholesterol ya lipoproteine ​​(HDLC), byongera igipimo ya HDLC kuri cholesterol yuzuye, kandi igabanye icyerekezo cya atherogene icyarimwe, Naringin irashobora guteza imbere ubwikorezi bwa cholesterol kuva plasma ikajya mwumwijima, gusohora umwijima no gusohoka, kandi bikabuza guhindura HDL kuri VLDL cyangwa LDL.Kubwibyo, naringin irashobora kugabanya ibyago byo kurwara arteriosclerose n'indwara z'umutima.Naringin irashobora kugabanya ibirimo cholesterol yuzuye muri plasma kandi igakomeza metabolisme yayo.

Ingaruka ya Hypolipidemic
Zhang Haide n'abandi.Bipimishije serum cholesterol (TC), cholesterol ya lipoprotein nkeya (LDL-C), plasma yo mu bwoko bwa lipoprotein cholesterol (HDL-C), triglyceride (TG) nibindi bintu byimbeba nyuma yubuyobozi bwimitsi binyuze mubushakashatsi bwinyamaswa Ibisubizo byerekanaga ko naringine ishobora kugabanya cyane serumu TC, TG na LDL-C kandi ugereranije byongera serumu HDL-C ku kigero runaka, byerekana ko naringin yagize ingaruka zo kugabanya lipide yamaraso mu mbeba.[

Igikorwa cya Antitumor
Naringin irashobora kugenga imikorere yumubiri no kubuza gukura kwikibyimba.Naringin afite ibikorwa kuri imbeba leukemia L1210 na sarcoma.Ibisubizo byerekanye ko igipimo cya thymus / umubiri wibipimo byimbeba byiyongereye nyuma yubuyobozi bwo mu kanwa bwa naringin, byerekana ko naringin ishobora kongera imikorere yumubiri.Naringin irashobora kugena urwego rwa lymphocytes T, gusana ubudahangarwa bw'umubiri wa kabiri buterwa na kanseri cyangwa radiotherapi na chimiotherapie, kandi bikongera ingaruka zo kwica selile.Biravugwa ko naringin ishobora kongera uburemere bwa thymus muri kanseri itera kanseri yimbeba, byerekana ko ishobora kongera imikorere yubudahangarwa no gukangurira ubushobozi bwayo bwo kurwanya kanseri.Byagaragaye ko ibishishwa bya pomelo byagize ingaruka mbi kuri sarcoma ya S180, naho igipimo cyo kubuza ibibyimba cyari 29.7%.

Antispasmodic na cholagogic
Ifite ingaruka zikomeye muri flavonoide.Naringin igira kandi ingaruka zikomeye mukwongera ururenda rwinyamaswa zigerageza.

Ingaruka zo Kurwanya no Kwitega
Ukoresheje fenol itukura nkikimenyetso cyingaruka zo kurandura indwara, ubushakashatsi bwerekana ko naringin ifite inkorora ikomeye ningaruka zo gusohora.

Gusaba Ivuriro
Ikoreshwa mu kuvura indwara ya bagiteri, imiti igabanya ubukana hamwe na anticancer.
Ifishi yo gusaba: suppository, amavuta yo kwisiga, inshinge, tablet, capsule, nibindi


  • Mbere:
  • Ibikurikira:

  • Andika ubutumwa bwawe hano hanyuma utwohereze