Neohesperidin
Ikoreshwa rya Synephrine Hydrochloride
Neohesperidin ni ubwoko bwa flavonoid compound iboneka cyane mubihingwa bya Cucurbitaceae kandi bifite antioxydeant na anti-inflammatory./h2>
Izina rya Neohesperidin
Izina ry'icyongereza: neohesperidin
Abashinwa Alias: neohesperidin |neohesperidin
Bioactivite ya Neohesperidin
Ibisobanuro: neohesperidin ni ifumbire ya flavonoide iboneka muri Cucurbitaceae, ifite antioxydeant na anti-inflammatory.
Ibyiciro bifitanye isano: inzira yerekana ibimenyetso >> ibindi >> ibindi
umurima wubushakashatsi >> gutwika / ubudahangarwa
Ibicuruzwa bisanzwe >> flavonoide
Mu Kwiga Vitro:
Hesperidin nshya itera apoptose muri kanseri y'ibere ya MDA-MB-231.Indangagaciro za IC50 za neohesperidin mu masaha 24 na 48 zari 47.4 ± 2,6, kimwe μ M na 32.5 ± 1.8 μ M。 Imvugo ya p53 na Bax yagenzuwe cyane mu ngirabuzimafatizo zavuwe na neohesperidin, mu gihe imvugo ya Bcl-2 yari hasi bigengwa [1].Neohesperidin yerekanye ibikorwa bya antioxydeant mu kizamini cya DPPH gikabije (IC50 = 22.31 μ g / mL） [2]。
Mu bushakashatsi bwa Vivo: neohesperidin (50mg / kg) yabujije cyane 55.0% HCl / Ethanol yatewe no gukomeretsa mu gifu.Muri pylorus ligated imbeba, neohesperidin (50 mg / kg) yagabanije cyane ururenda rwa gastrica na aside gastricike kandi byongera pH [1].Ubuvuzi bwa Neohesperidin bwagabanije cyane glucose yamaraso yo kwiyiriza ubusa, glucose yamaraso hamwe na proteine ya glycosylated (GSP) mu mbeba.Yiyongereye cyane kwihanganira glucose yo mu kanwa no kumva insuline, kandi igabanya insuline mu mbeba za diyabete.Neohesperidin yagabanije cyane serumu triglyceride, cholesterol yuzuye, urugero rwa leptine hamwe nigipimo cyumwijima mu mbeba [3].
Ubushakashatsi ku nyamaswa: imbeba: Imbeba zose zisonzesha amasaha 6 mbere yikizamini, hanyuma zigaburirwa amazi cyangwa neohesperidin mugaburira ku gahato.Kuri OGTT na ITT, imbeba zatewe inshinge 2G / kg BW glucose cyangwa 1iu / kg BW insuline.Amaraso yakusanyirijwe mu mitsi ya caudal kugirango bapime urugero rw'amaraso glucose (iminota 0) mbere yo gutera glucose cyangwa insuline.Ibipimo by'amaraso bya glucose byapimwe ku minota 30, 60, 90 na 120 [3].
Reba: [1].Lee JH, n'abandi.Ingaruka zo gukingira neohesperidin na poncirine zitandukanijwe n'imbuto za Poncirus trifoliata ku ndwara zishobora gutera.Phytother Res.2009 Ukuboza; 23 (12): 1748-53.
[2].Xu F, n'abandi.Neohesperidin itera apoptose ya selile mumabere yabantu adenocarcinoma MDA-MB-231 ikoresheje inzira ya signal ya Bcl-2 / Bax-yunganirwa.Nat Prod Commun.2012 Ugushyingo; 7 (11): 1475-8.
[3].Jia S, n'abandi.Indwara ya Hypoglycemic na hypolipidemic ya neohesperidine ikomoka kuri Citrus aurantium L. mu mbeba ya diabete ya KK-A (y).Imikorere y'ibiryo.2015 Werurwe; 6 (3): 878-86.
Ibintu bya fiziki ya Himiki ya Neohesperidin
Ubucucike: 1.7 ± 0.1 g / cm3
Ingingo yo guteka: 933.7 ± 65.0 ° C kuri 760 mmHg
Ingingo yo gushonga: 239-243 º C.
Inzira ya molekulari: C28H34O15
Uburemere bwa molekuline: 610.561
Ingingo ya Flash: 306.7 ± 27.8 ° C.
Misa nyayo: 610.189758
PSA: 234.29000
LogP: 2.44
Kugaragara: 0.0 ± 0.3 mmHg kuri 25 ° C.
Umuvuduko wamazi: 0.0 ± 0.3 mmHg kuri 25 ° C.
Ironderero: 1.695
Uburyo bwo kubika: 2-8 ° C.
Amakuru mashya yumutekano wa Hesperidin
Ibikoresho byo kurinda umuntu ku giti cye: amaso;Uturindantoki;andika N95 (Amerika);andika P1 (EN143) iyungurura
Itangazo ryumutekano (Uburayi): s22-s24 / 25
Kode yo gutwara ibicuruzwa biteje akaga: nonh kuburyo bwose bwo gutwara
Wgk Ubudage: 3
RTECS No.: Dj2981400
Ubuvanganzo bwa Neohesperidin
Kugereranya metabolike no kwandukura inyandiko ya diploide yikubye kabiri hamwe na citrus root diproside (C. junos cv. Ziyang xiangcheng) yerekana agaciro kayo ko kunoza imihangayiko.
BMC Ibimera Biol.15, 89, (2015)
Polyploidy yakunze gufatwa nkibimera kugirango bihuze neza nibidukikije.Tetraploid citrus umuzi uteganijwe kwihanganira imihangayiko ikomeye kuruta diploid.Byinshi bya ...
Ougan (Citrus reticulata cv. Suavissima) flavedo ivamo ihagarika umuvuduko wa kanseri ibangamira inzibacyuho ya epiteliyale-mesenchymal muri selile SKOV3.
Chin.Med.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo ikuramo (OFE) yerekanye ingaruka zishobora kurwanya ibibyimba hamwe nuburyo budasobanutse.Ubu bushakashatsi bugamije gusuzuma ibishobora kurwanya anti-metastatike ...
Hesperidin, nobiletin, na tangeretine hamwe hamwe bashinzwe kurwanya anti-neuroinflammatory ubushobozi bwigishishwa cya tangerine (Citri reticulatae pericarpium).
Imiti y'ibiryo.Uburozi.71, 176-82, (2014)
Kubuza microglial activation-medrated neuroinflammation byabaye intego yemeza iterambere ryibiribwa bikora kugirango bivure indwara zifata ubwonko.Igishishwa cya Tangerine (Citri reticulata ...
Icyongereza Alias Ya Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-imwe, 7 - [[2-O- - (3-hydroxy-4-mikorerexyphenyl) -, (2S) -
(2S) -5-Hydroxy-2-- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3 ', 5,7-trihydroxyflavanone-7-
4H-1-Benzopyran-4-imwe, 2,3-dihydro-7 - ((2-O- (6-deoxy-α-L-mannopyranosyl) -β-D-glucopyranosyl) oxy) -5-hydroxy-2 - (3-hydroxy-4-mikorerexyphenyl) -, (S) -
Hesperetin 7-O-neohesperidoside
