Obtusin
Gukoresha Obtusin
Obtusin, ikomoka ku mbuto ya cassia, ni intore ihitamo cyane kandi irushanwa irwanya monoamine oxydease-A (hmao-a), hamwe na IC50 ya 11.12 μ M. Ki ni 6.15.Obtusin igira uruhare mu gukumira indwara zifata ubwonko, cyane cyane guhangayika no kwiheba.
Izina rya Obtusin
Izina ry'icyongereza: Obtusin
Bioactivite ya Obtusin
Ibisobanuro: obtusin ikomoka ku mbuto ya cassia.Nibihitamo cyane kandi birwanya irwanya monoamine oxyde-A (hmao-a), hamwe na IC50 ya 11.12 μ M. Ki ni 6.15.Obtusin igira uruhare mu gukumira indwara zifata ubwonko, cyane cyane guhangayika no kwiheba.
Ibyiciro bifitanye isano: inzira yerekana inzira >> inzira ya signal ya neural >>> monoamine oxydease
Urwego rwubushakashatsi >> indwara zifata ubwonko
Intego: IC50: 11.12 μ M (hMAO-A) [1] Ki: 6.15 (hMAO-A) [1]
Reba: [1] Paudel P, n'abandi.Muri Vitro no muri Silico Umuntu wa Monoamine Oxidase Inhibitory Potential ya Anthraquinone, Naphthopyrones, na Laptone ya Naphthalenic yo muri Cassia obtusifolia Imbuto Linn.ACS Omega.2019 Nzeri 18;4 (14): 16139-16152.
Imiterere ya fiziki ya Himiki ya Obtusin
Ubucucike: 1.4 ± 0.1 g / cm3
Ingingo yo guteka: 614.9 ± 55.0 ° C kuri 760 mmHg
Inzira ya molekulari: c18h16o7
Uburemere bwa molekuline: 344.315
Ingingo ya Flash: 227.0 ± 25.0 ° C.
Misa nyayo: 344.089600
PSA: 102.29000
LogP: 4.10
Umuvuduko wamazi: 0.0 ± 1.8 mmHg kuri 25 ° C.
Ironderero ridakuka: 1.634
Amakuru yumutekano wa Obtusin
Kode ya gasutamo: 2914690090
Ubuvanganzo: Kameron, Donald W;Feutrill, Geoffrey I.;Urusimbi, Glenn B.;Stavrakis, Amabaruwa ya John Tetrahedron, 1986, umuzingo.27, # 41 p.4999 - 5002
Gasutamo ya Obtusin
Kode ya gasutamo: 2914690090
Incamake y'Ubushinwa: Incamake y'Ubushinwa
Incamake: 2914690090 izindi quinone conditions Imiterere yubugenzuzi: Ntayo。 TVA: 17.0% rate Igipimo cyo kugabanyirizwa imisoro: 9.0% tarif Igiciro cya MFN: 5.5% tarif Igiciro rusange: 30.0%
Icyongereza Alias Ya gasutamo
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Kugenzura ubuziranenge bwibicuruzwa
1. Isosiyete yaguze ibyuma bya kirimbuzi bya kirimbuzi (Bruker 400MHz) spekrometrike, icyuma cyamazi cyamazi (LCMS), icyerekezo cya gazi ya gazi (GCMs), icyerekezo rusange (amazi SQD), ibintu byinshi byikora byisesengura byimikorere ya chromatografi, chromatografi yitegura, nibindi .
2. Isosiyete ikomeje ubufatanye bwa hafi no kuvugana n’ibigo by’ubushakashatsi mu bumenyi nk’ikigo cya Shanghai gishinzwe kurwanya ibiyobyabwenge, urubuga rwa Nanjing biomedical service service hamwe n’ikigo cy’isesengura n’ibizamini by’ikigo cy’ubushakashatsi ku nganda z’imiti ya Shanghai.
3. Isosiyete ikorana umwete icyemezo cya laboratoire y’abandi bantu batatu, kandi biteganijwe ko izabona icyemezo cya CNAs Laboratoire cyemewe muri 2021.
