Acide Salvianolike B / Lithospermic aside B Lithospermate-B CAS No.115939-25-8
Amakuru y'ingenzi
Acide Salvianolike B ni ihuriro rya molekile eshatu za Danshensu na molekile imwe ya acide cafeque.Nimwe muma acide salvianolike yize.Ifite ingaruka zikomeye za farumasi kumutima, ubwonko, umwijima, impyiko nizindi ngingo.Iki gicuruzwa gifite ingaruka zo guteza imbere gutembera kwamaraso no gukuraho ihagarikwa ryamaraso, gucukura meridian no gukora collaterals.Ikoreshwa cyane cyane mu kuvura indwara yimitsi iterwa no guhagarara kwamaraso ibuza meridiya, nko kunanirwa igice cyumubiri ningingo, intege nke, ububabare bwamasezerano, kunanirwa na moteri, umunwa no guta amaso, nibindi.
Alias:aside salvianolike B, aside salvianolike B, aside salvianolike B.
Izina ry'icyongereza:aside salvianolike B.
Inzira ya molekulari:c36h30o16
Uburemere bwa molekile:718.62
CAS No.:115939-25-8
Uburyo bwo kumenya:HPLC ≥ 98%
Ibisobanuro:10mg, 20mg, 100mg, 500mg, 1g (birashobora gupakirwa ukurikije ibyo abakiriya bakeneye)
Imikorere no gukoresha:Iki gicuruzwa gikoreshwa mukugena ibirimo.
Imiterere yumubiri nubumara
Ibyiza:ibicuruzwa ni ifu yera.
Uburyohe burakaze gato kandi burakomeye, hamwe nubushuhe butera ibintu.Gushonga mumazi, Ethanol na methanol.
Acide Salvianolike B ikorwa no guhuza molekile 3 za aside salvianolike na molekile 1 ya acide cafeque.Ifite amatsinda abiri ya carboxyl kandi ibaho muburyo bwumunyu utandukanye (K +, Ca2 +, Na +, NH4 +, nibindi).Muburyo bwa Decoction hamwe nibitekerezo, igice gito cya acide salvianolike B ihindurwamo hydrolyz na acide yumutuku wa oxyde na acide salvianolique, naho igice cya acide salvianolique B kiba aside rosmarinike mubihe bya aside;Acide Salvianolike A na C irashobora kuba tautomeric mugisubizo.
Ibisobanuro
＞ 5% ， ＞ 10% ， ＞ 50% ， ＞ 70% ， ＞ 90% ， 98%
Uburyo bwo kuvoma
Radix Salviae Miltiorrhizae yarajanjaguwe, ashyirwa mu kigega cyo kuyikuramo, ashyiramo inshuro 8 zingana na 0.01mol / l acide hydrochloric ijoro ryose, hanyuma azenguruka inshuro 14 z'amazi.Igisubizo cyakuweho gisukurwa na AB-8 macroporous resin inkingi.Ubwa mbere, kura hamwe na 0.01mol / l hydrochloric aside kugirango ukureho umwanda utamenyekanye, hanyuma usibangane na 25% Ethanol kugirango ukureho umwanda mwinshi cyane.Hanyuma, shyira ingufu za 40% za Ethanol munsi yumuvuduko ukabije wo kugarura Ethanol no gukonjesha-kugirango ubone aside yose ya Saliviya miltiorrhiza fenolike ifite isuku irenga 80%.
Menya
Fata 1g y'ibicuruzwa, ubisya, ongeramo 5ml ya Ethanol, ushyire byuzuye, uyungurure, fata ibitonyanga bike bya filtrate, ubishyire kumurongo wimpapuro, uyumishe, ubirebe munsi y itara rya ultraviolet (365nm), werekane ubururu- ibara rya fluorescence, umanike impapuro zungurura mumacupa yumuti wa ammonia yibanze (udahuye nubutaka bwamazi), uyikuremo nyuma yiminota 20, uyitegereze munsi y itara rya ultraviolet (365nm), werekane fluorescence yubururu-icyatsi.
Acide:fata igisubizo cyamazi munsi yikintu gisobanutse, kandi agaciro ka pH kagomba kuba 2.0 ~ 4.0 (umugereka wa Pharmacopoeia yubushinwa 1977 Edition).
Kumenya Ibirimo
Byagenwe nubushakashatsi buhanitse bwa chromatografiya (Umugereka wa VI D, Umubumbe wa I, Pharmacopoeia yo mu Bushinwa, EDITION 2000).
Octadecyl silane ihujwe na silika gel yakoreshejwe nkuwuzuza mubihe bya chromatografique hamwe nikizamini cya sisitemu;Methanol acetonitrile formic aside aside (30: 10: 1: 59) yari icyiciro kigendanwa;Uburebure bwumurambararo bwari 286 nm.Umubare w'ibyapa bya teoretiki ubarwa ukurikije aside ya salvianolike B ntushobora kuba munsi ya 2000.
Gutegura igisubizo cyerekeranye no gupima neza urugero rukwiye rwa acide salvianolique B hanyuma ukongeramo amazi kugirango ikore 10% kuri 1ml μ G.
Gutegura igisubizo cyibizamini bifata hafi 0.2g yibicuruzwa, ubipime neza, ubishyire mu icupa ripima 50ml, ongeramo urugero rukwiye rwa methanol, sonic muminota 20, ukonje, wongere amazi mubipimo, ubinyeganyeze neza, ushungura , gupima neza 1ml ya filtrate ikomeza, uyishyire mu icupa ripima 25ml, ongeramo amazi murwego, uzunguze neza.
Uburyo bwo kugena bukuramo neza 20% yumuti wigenzura na 20% yumuti wikizamini μ l.Injira mumazi ya chromatografi kugirango ubyemeze.
Imiti ya farumasi
Acide Salvianolike B ni ihuriro rya molekile eshatu za Danshensu na molekile imwe ya acide cafeque.Nimwe muma acide salvianolike yize.Ifite ingaruka zikomeye za farumasi kumutima, ubwonko, umwijima, impyiko nizindi ngingo.
Antioxidant
Acide Salvianolike B ifite antioxydeant ikomeye.Ubushakashatsi bwakozwe muri vivo no muri vitro bwerekana ko aside salvianolike B ishobora gukuramo ogisijeni yubusa kandi ikabuza lipide peroxidation.Imbaraga zacyo zirenze iyo vitamine C, vitamine E na mannitol.Nibimwe mubicuruzwa bisanzwe bizwi bifite ingaruka zikomeye za antioxydeant Ubushakashatsi bwa farumasi bwerekana ko aside salvianolike yo gutera inshinge igira ingaruka nziza ya antioxydeant, ikabuza gukusanya platine na trombose, kandi ishobora kongera igihe cyo kubaho kwinyamaswa munsi ya hypoxia.Ibisubizo byerekanye ko aside salvianolike yo gutera inshinge (60 ~ 15mg / kg) ishobora kuzamura cyane icyuho cy’imitsi y’imbeba zifite imvune zo mu bwonko bwitwa ischemia-reperfusion, kunoza imyitwarire no kugabanya cyane agace k’ubwonko bw’ubwonko.Hariho itandukaniro rikomeye hagati ya dosiye ndende kandi yo hagati (60 na 30mg / kg);Acide Salvianolique yo gutera inshinge irashobora kunoza cyane kwangirika kwimitsi yatewe na FeCl3 iterwa nubwonko bwubwonko bwimbeba ku mbeba nyuma yamasaha 1, 2 na 24 nyuma yubuyobozi, ibyo bikaba bigaragarira mugutezimbere imyitwarire mibi no kugabanya agace k’ubwonko bw’ubwonko;Acide Salvianolike 40 mg / kg yo gutera inshinge yabujije cyane kwegeranya platine yinkwavu yatewe na ADP, aside arachidonic na kolagen, kandi ibipimo byo kubuza byari 81.5%, 76.7% na 68.9%.Acide Salvianolike 60 na 30mg / kg yo gutera inshinge yabujije trombose imbeba;Acide Salvianolike 60 na 30mg / kg yo gutera inshinge byongereye cyane igihe cyo kubaho kwimbeba munsi ya hypoxia.
Gusaba Ivuriro
Iki gicuruzwa gifite ingaruka zo guteza imbere gutembera kwamaraso no gukuraho ihagarikwa ryamaraso, gucukura meridian no gukora collaterals.Ikoreshwa cyane cyane mu kuvura indwara yimitsi iterwa no guhagarara kwamaraso ibuza meridiya, nko kunanirwa igice cyumubiri ningingo, intege nke, ububabare bwamasezerano, kunanirwa na moteri, umunwa no guta amaso, nibindi.
Ububiko
Ahantu hakonje kandi humye.
Igihe cyemewe
Imyaka ibiri.
Uburyo bwo Kubika
2-8 ° C, ibitswe ahantu hakonje kandi humye kandi kure yumucyo.
Ibintu bikeneye kwitabwaho
Ibicuruzwa bigomba kubikwa ku bushyuhe buke.Niba ihuye numwuka igihe kirekire, ibirimo bizagabanuka.
