Acide Salvianolike C.
Intego
Acide Salvianolike C ni inzitizi idahwitse ya cytochrome p4502c8 (cyp2c8) hamwe na inhibitor ya cytochrome P4502J2 (CYP2J2) ifite ubukana buciriritse.Indangagaciro za Ki kuri cyp2c8 na CYP2J2 ni 4.82 ukurikije μ M na 5.75 μ M.
Izina ry'icyongereza
(2R) -3- (3,4-Dihydroxyphenyl) -2 - ({(2E) -3- [2- (3,4 propenoyl} oxy) aside aside
Icyongereza Alias
(2R) -3- (3,4-Dihydroxyphenyl) -2 - ({(2E) -3- [2- -enoyl} oxy) aside aside
(2R) -3- (3,4-Dihydroxyphenyl) -2 - ({(2E) -3- [2- (3,4 propenoyl} oxy) aside aside
Acide ya Benzenepropanoic, α - [[((2E) -3- [2- 4-dihydroxy-, (αR) -
Acide Salvianolike C.
Ibyiza bya fiziki ya Himiki ya Acide Salvianolike C.
Ubucucike: 1,6 ± 0.1 g / cm3
Ingingo yo guteka: 844.2 ± 65.0 ° C kuri 760 mmHg
Inzira ya molekulari: C26H20O10
Uburemere bwa molekuline: 492.431
Ingingo yerekana: 464.4 ± 34.3 ° C.
Misa nyayo: 492.105652
PSA: 177.89000
LogP: 3.12
Umuvuduko wamazi: 0.0 ± 3,3 mmHg kuri 25 ° C.
Igipimo cyangirika: 1.752
Bioactivite ya Acide Salvianolike C.
Ibisobanuro:
Acide Salvianolike C ni inzitizi idahwitse ya cytochrome p4502c8 (cyp2c8) hamwe na inhibitor ya cytochrome P4502J2 (CYP2J2) ifite ubukana buciriritse.Indangagaciro za Ki kuri cyp2c8 na CYP2J2 ni 4.82 ukurikije μ M na 5.75 μ M。
Ibyiciro bijyanye:
Inzira yerekana inzira >> metabolike enzyme / protease >> cytochrome P450
Urwego rwubushakashatsi >> kanseri
Ibicuruzwa bisanzwe >> ibindi
Intego:
CYP2C8: 4.82 μM (Ki)
CYP2J2: 5.75 μM (Ki)
Mu Kwiga Vitro:
Acide Salvianolike C ni inzitizi ivanze iringaniye ya cyp2c8 inhibitor na CYP2J2.KIS ya cyp2c8 na CYP2J2 ni 4.82 na 5.75 uko bikurikirana μ M [1]。 1 na 5 μ M aside salvianolike C (SALC) irashobora kubuza cyane LPS iterwa n'umusaruro.Acide Salvianolike C yagabanije cyane imvugo ya iNOS.Acide Salvianolike C ibuza LPS iterwa na TNF- α ， IL-1 β ， IL-6 na IL-10 byabyaye umusaruro mwinshi.Acide Salvianolike C ibuza LPS iterwa na NF- κ B.Acide Salvianolike C nayo yongereye imvugo ya Nrf2 na HO-1 muri microglia ya BV2 [2].
Mu bushakashatsi bwa Vivo:
Acide Salvianolike C (20mg / kg) ivura byagabanije cyane gutinda.Mubyongeyeho, kuvura SALC (10 na 20 mg / kg) byongereye cyane umubare wambukiranya urubuga ugereranije nitsinda ryicyitegererezo rya LPS.Ugereranije nitsinda ryicyitegererezo, imiyoborere itunganijwe ya acide salvianolique C hasi ubwonko bwateganijwe TNF- α ， IL-1 β N'urwego rwa IL-6.Urwego rwa iNOS na COX-2 mu bwonko bwubwonko na hippocampus yimbeba byari hejuru kurenza ibyo mu itsinda rishinzwe kugenzura, mu gihe kuvura aside salvianolique C byagabanutse cyane byategekaga cortex na hippocampus.Acide Salvianolike C (5, 10 na 20 mg / kg) kuvura byongereye p-ampk, Nrf2, HO-1 na NQO1 murwego rwimbeba cerebral cortex na hippocampus muburyo buterwa na dose [2].
Reba:
[1].Xu MJ, n'abandi.Ingaruka zo kubuza ibice bya Danshen kuri CYP2C8 na CYP2J2.Chem Biol Imikoranire.2018 Jun 1;289: 15-22.
[2].Indirimbo J, n'abandi.Gukora kwa Nrf2 byerekana na acide salvianolique C ihuza NF κ B yifashishije igisubizo cyo gutwika haba muri vivo ndetse no muri vitro.Int Immunopharmacol.2018 Ukwakira;63: 299-310.
