3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Fa'aaogāina ole Methylnissolin
Methylnisolin (astrapterocarpan) e vavae ese mai Astragalus membranaceus ma e mafai ona taofia le faʻalauteleina o sela e faʻaosoina e le platelet-derived growth factor (PDGF) - BB, faʻatasi ai ma le IC50 o le 10 μ M. Methylnisolin faʻalavelaveina le phosphorylation o le extracellular signal regulated kinase 1 / 2 (ericic 1 / 2) (e. 2) mitogen activated protein (faafanua) kinase faʻaosoina e le PDGF-BB.Methylnisolin fa'alavelaveina le fa'atupuina o le PDGF-BB o sela maso lamolemole vascular e ala i le taofia o le ERK1 / 2 MAP kinase cascade.
Igoa ole Methylnissolin
Igoa Igilisi:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Fa'aigoa Saina: 3-hydroxy-9,10-dimethoxy sandalwood mumu |Astragalus mumu
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy sandalwood mumu
Gaoioiga Fa'aletino ole Methylnissolin
Fa'amatalaga: methylnisolin (astraterocarpan) e vavae ese mai le Astragalus membranaceus
ma e mafai ona fa'alavelaveina le fa'atuputeleina o le sela fa'aosoina e le platelet-derived growth factor (PDGF) - BB.
O le IC50 o le 10 μ M. Methylnisolin e taofia ai le phosphorylation o le faʻailoga extracellular.
fa'atulafonoina kinase 1/2 (eric1/2) mitogen activated protein (faafanua) kinase fa'aosoina e
PDGF-BB.Methylnisolin e taofia le PDGF-BB fa'aosoina le fa'atuputeleina o le lamolemole vascular
sela maso e ala i le taofia ERK1 / 2 MAP kinase cascade.
Vaega Feso'ota'i: fanua su'esu'e > > ma'i fatu fatu
ala faailo > > polotini tyrosine kinase > > PDGFR
ala faailo > > MAPK / ERK ala faailo > > ERK
ala fa'ailo > > sela fatu ma le ala Wnt > > ERK
Fa'alavelave:PDGFR:10 μM (IC50)
ERK1
ERK2
Fa'amatalaga:[1].Ohkawara S, et al.O le Astrapterocarpan e vavae ese mai le Astragalus membranaceus e taofia ai le faʻateleina o sela maso lamolemole vascular.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.
Amioga fa'aletino ole Methylnissolin
Malosi: 1.3 ± 0.1 g / cm3
Fa'apuna: 428.9 ± 45.0 ° C ile 760 mmHg
Fuafuaga mole: c17h16o5
Malosi mole: 300.306
Fa'asao: 213.2 ± 28.7 ° C
Misasa'o: 300.099762
PSA:57.15000
LogP:2.45
O'omiga ausa: 0.0 ± 1.1 mmHg ile 25°C
Fa'asino Upu: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., na faavaeina ia Mati 2012, o se atinaʻe faʻatekonolosi maualuga faʻatasi ai le R & D, gaosiga ma le faʻatau.E masani ona auai i le gaosiga, aganuʻu ma le gaosiga faʻagasologa o le atinaʻeina o vaega malosi o mea faʻanatura, mea faʻaleaganuʻu vailaʻau Saina faʻamatalaga ma vailaʻau leaga.O loʻo tu le kamupani i Saina Pharmaceutical City, Taizhou City, Jiangsu Province, e aofia ai le 5000 sikuea mita faʻavae gaosiga ma le 2000 sikuea mita R & D faavae.O lo'o fa'atautaia tele a'oa'oga su'esu'e fa'asaienisi, iunivesete ma atina'e gaosiga o mea'ai fa'ato'aga i le atunu'u.
I le taimi nei, ua tatou atiina ae le sili atu i le 1500 ituaiga o reagents tuufaatasia faalenatura, ma faatusatusa ma calibrated sili atu i le 300 ituaiga o mea e faasino i ai, lea e mafai ona ausia atoatoa manaoga asiasiga i aso taitasi o le tele o inisitituti suesuega faasaienisi, fale suesue iunivesite ma decoction vaega gaosiga pisinisi.
Faʻavae i luga o le mataupu faavae o le faʻatuatua lelei, o loʻo faʻamoemoe le kamupani e galulue faʻatasi ma a tatou tagata faʻatau.O le matou fa'amoemoe o le tautuaina lea o le fa'aonaponei o vaila'au fa'aSaina.
Aofa'i Pisinisi Avanoa O le Kamupani
1. R & D, gaosiga ma le fa'atau atu o mea e fa'atatau i vaila'au o vaila'au fa'aSaina;
2. Fa'aleaganu'u fa'aSaina vaila'au monomer tu'ufa'atasi e tusa ai ma uiga fa'atau
3. Su'esu'ega ile tulaga lelei ma le fa'agasologa ole atina'eina ole vaila'au fa'aSaina (la'au) fa'aleaganu'u
4. Fa'atekonolosi felagolagoma'i, fesiitaiga ma su'esu'ega ma atina'e fou o vaila'au.
